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Bcrp knockout rats
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ADMET
Tissue distribution
ADMET
Fuchs H, Kishimoto W, Gansser D, Tanswell P, Ishiguro N.,
Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats.,
Drug Metab Dispos. 2014 Oct;42(10):1761-5.
Zamek-Gliszczynski MJ, Bedwell DW, Bao JQ, Higgins JW.,
Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.,
Drug Metab Dispos. 2012 Sep;40(9):1825-33.
Huang L, Li X, Roberts J, Janosky B, Lin MH.,
Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats.,
Xenobiotica. 2015;45(6):547-55
Miyake T.,
Estimating Efflux Transporter-Mediated Disposition of Molecules beyond the Rule of Five (bRo5) Using Transporter Gene Knockout Rats.,
Biol Pharm Bull. 2020 Mar 1;43(3):384-392.
Kimura H, Yagi Y, Mikamo M, Maeda K, Kagawa S, Arimitsu K, Higashi T, Nishii R, Ono M, Nakamoto Y, Togashi K, Kusuhara H, Saji H.,
Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging.,
Drug Metab Pharmacokinet. 2019 Oct;34(5):317-324
Sato S, Tohyama K, Kosugi Y.,
Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities.,
Eur J Pharm Sci. 2020 Jan 15;142:105119.
Ganguly S, Panetta JC, Roberts JK, Schuetz EG.,
Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice.,
Drug Metab Dispos. 2018 Jul;46(7):1014-1022
Zamek-Gliszczynski MJ, Goldstein KM, Paulman A, Baker TK, Ryan TP.,
Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics.,
Drug Metab Dispos. 2013 Jun;41(6):1174-8.
Bridges CC, Zalups RK, Joshee L.,
Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells.,
Toxicol Appl Pharmacol. 2015 Jun 1;285(2):110-7.
Tissue distribution
Nicolas JM, Chanteux H, Nicolaï J, Brouta F, Viot D, Rosseels ML, Gillent E, Bonnaillie P, Mathy FX, Long J, Helmer E.,
Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions,
Eur J Pharm Sci. 2020 Jan 15;142:105122. doi: 10.1016/j.ejps.2019.105122. Epub 2019 Oct 31.
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