Broad Scope and Right-Size Solutions for In Vivo Discovery and Toxicology

With the expertise of Inotiv’s scientists and dedication to the 3Rs, we collaborate with you to perform customized studies that meet your unique drug development needs, while minimizing the number of study subjects. Our AAALAC-accredited laboratories are built for purpose and support discovery through GLP regulatory studies using all common research models.

Throughout your project, strong lines of communication promote your success, with study design, conduct, and data interpretation that exceed your expectations. We are large enough to provide the experience and resources to complete your projects expertly and on time, while remaining flexible, accessible, and responsive to your needs.

Discovery

Obtain high-quality data with lead optimization and candidate selection studies to evaluate tolerability, pharmacology, and DMPK parameters.

We support molecules of all classes, from small molecules and biologics to gene and cellular therapeutics.

Novel Pharmacology Models

When it benefits your study, your Inotiv team will develop fit-for-purpose, cost-effective, non-routine models of disease. Unique models we have developed to focus on specific targets of interest include:

Diabetes and metabolic disease
Diet-induced hyperlipidemia/atherosclerosis
Inflammation
Pulmonary disease
Sebaceous gland development
Liver-humanized rodent models for hepatic disease, gene delivery, and gene expression studies

General Toxicology

From acute tolerability through multi-year and multi-generational safety assessments, we provide a consultative, responsive experience. You will receive timely and reliable reports that meet or exceed regulatory guidelines. For over 40 years, Inotiv’s experienced and proven safety assessment teams have backed thousands of successful IND and NDA/BLA submissions. In addition to routine protocols, our flexible, fast, and responsive team routinely develops custom protocols to meet our clients’ challenges. Our GLP toxicology services are comprehensive. Along with the in vivo conduct, we also provide:

Full histopathology support
Clinical pathology services
Dose formulation analytical development, validation, and analysis
Bioanalytical development, validation, and analysis
Pharmacokinetics/toxicokinetics (PK/TK) data analysis and interpretation

Surgical Models and Medical Device Testing Surgical Models and Medical Device Testing Our nonclinical testing services feature veterinary surgeons, state-of-the-art imaging, and a commitment to excellence to advance your medical device.

Histology Histology Our industry-leading histology laboratories support your discovery and nonclinical development projects with a wide range of services. From tissue processing to digital analysis, our team delivers the quality you expect.

Pathology Pathology Access world-class anatomical, clinical, and medical device pathology services, from routine histochemistry, IHC, IF, and ISH to stereology.

Drug Metabolism and Pharmacokinetics (DMPK) Drug Metabolism and Pharmacokinetics (DMPK) Whatever you need, from method development to metabolite ID, our phase-appropriate bioanalytical services help you analyze, answer, and advance.

Disease Pharmacology (In Vitro and In Vivo) Disease Pharmacology (In Vitro and In Vivo) Access a wide range of in vivo preclinical early-stage research, efficacy, pharmacology, and safety studies. Our experienced staff has the expertise to offer a wide range of study designs.

Discovery

Novel Pharmacology Models

General Toxicology

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