Wistar Han® outbred rats
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Marshall, Hayley J; Pezze, Marie A; Fone, Kevin C F; Cassaday, Helen J;, Age-related differences in appetitive trace conditioning and novel object recognition procedures., Neurobiology of learning and memory Vol.164, 2019
Cabiati M, Salvadori C, Sapio A, Burchielli S, Carlucci L, Moscato S, Sabatino L, Caselli C, Mattii L, Del Ry S., Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges, Exp Gerontol. 2020 May;133:110879. doi: 10.1016/j.exger.2020.110879. Epub 2020 Feb 17.
Gull S, Gaser C, Herrmann KH, Urbach A, Boehme M, Afzal S, Reichenbach JR, Witte OW, Schmidt S., Brain Macro-Structural Alterations in Aging Rats: A Longitudinal Lifetime Approach., Cells. 2023 Jan 28;12(3). pii: 432. doi: 10.3390/cells12030432.
Aitken TJ, Crabtree JE, Jensen DM, Hess KH, Leininger BR, Tessem JS., Decreased proliferation of aged rat beta cells corresponds with enhanced expression of the cell cycle inhibitor p27(KIP1), Biol Cell. 2021 Dec;113(12):507-521. doi: 10.1111/boc.202100035. Epub 2021 Sep 27.
Rickard, R. F., Engelbrecht, G. H., & Hudson, D. A. (2011)., Experimental investigation of two techniques of arterial microanastomosis used to manage a small-to-large diameter discrepancy., Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS, 64(8), 1088-1095. doi:10.1016/j.bjps.2011.03.011 [doi]
Rickard, R. F., McPhaden, A. R., & Hudson, D. A. (2014), Healing of two microarterial anastomoses with diameter mismatch, The Journal of Surgical Research, 191(1), 239-49.e3. doi:10.1016/j.jss.2014.03.011 [doi]
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Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP., Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia, PLoS One. 2020 Jun 24;15(6):e0234653. doi: 10.1371/journal.pone.0234653. eCollection 2020.
Werkman IL, Kövilein J, de Jonge JC, Baron W., Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination, J Neurochem. 2020 Jun 30. doi: 10.1111/jnc.15113. Online ahead of print.
Anderton, M. J., Mellor, H. R., Bell, A., Sadler, C., Pass, M., Powell, S., . . . Heier, A. (2011)., Induction of heart valve lesions by small-molecule ALK5 inhibitors, Toxicologic Pathology, 39(6), 916-924. doi:10.1177/0192623311416259 [doi]
Macdonald, D., Tessari, M. A., Boogaard, I., Smith, M., Pulli, K., Szynol, A., . . . Munoz-Sanjuan, I. (2014)., Quantification assays for total and polyglutamine-expanded huntingtin proteins., PloS One, 9(5), e96854. doi:10.1371/journal.pone.0096854 [doi]
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Jernigan NL, Naik JS, Resta TC., Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension., J Physiol. 2021 Nov;599(21):4749-4762. doi: 10.1113/JP282231. Epub 2021 Sep 25.
Kalafateli, A. L., Vallof, D., & Jerlhag, E. (2018), Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents, Addiction Biology, doi:10.1111/adb.12603 [doi]
Kalafateli, Aimilia Lydia; VallĂśf, Daniel; Jerlhag, Elisabet;, Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents, Addiction biology Vol.24, 2019
Vestlund J, Bergquist F, Licheri V, Adermark L, Jerlhag E., Activation of glucagon-like peptide-1 receptors and skilled reach foraging, Addict Biol. 2020 Aug 8:e12953. doi: 10.1111/adb.12953. Online ahead of print.
Vestlund J, Bergquist F, Licheri V, Adermark L, Jerlhag E., Activation of glucagon-like peptide-1 receptors and skilled reach foraging, Addict Biol. 2021 May;26(3):e12953. doi: 10.1111/adb.12953. Epub 2020 Aug 8.
Sousa Fialho MDL, Purnama U, Dennis KMJH, Montes Aparicio CN, Castro-Guarda M, Massourides E, Tyler DJ, Carr CA, Heather LC., Activation of HIF1 Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart., Diabetes. 2021 Nov;70(11):2518-2531. doi: 10.2337/db21-0398. Epub 2021 Sep 15.
Lundberg, Stina; Högman, Cecilia; Roman, Erika;, Adolescent Exploratory Strategies and Behavioral Types in the Multivariate Concentric Square FieldTM Test., Frontiers in behavioral neuroscience Vol.13, 2019
Schneider, P., Bindila, L., Schmahl, C., Bohus, M., Meyer-Lindenberg, A., Lutz, B., . . . Schneider, M. (2016), Adverse social experiences in adolescent rats result in enduring effects on social competence, pain sensitivity and endocannabinoid signaling., Frontiers in Behavioral Neuroscience, 10, 203. doi:10.3389/fnbeh.2016.00203 [doi]
Joekel DE, Nur S, Monné Rodriguez J, Kronenberg PA, Kipar A, LeibundGut-Landmann S, Deplazes P., Agranulocytosis leads to intestinal Echinococcus multilocularis oncosphere invasion and hepatic metacestode development in naturally resistant Wistar rats, Parasitology. 2020 Oct 22:1-10. doi: 10.1017/S0031182020002012. Online ahead of print.
Joekel DE, Nur S, Monné Rodriguez J, Kronenberg PA, Kipar A, LeibundGut-Landmann S, Deplazes P., Agranulocytosis leads to intestinal Echinococcus multilocularis oncosphere invasion and hepatic metacestode development in naturally resistant Wistar rats, Parasitology. 2021 Jan;148(1):53-62. doi: 10.1017/S0031182020002012. Epub 2020 Oct 22.
Grotell M, den Hollander B, Jalkanen A, Törrönen E, Ihalainen J, de Miguel E, Dudek M, Kettunen MI, Hyytiä P, Forsberg MM, Kankuri E, Korpi ER., Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity, Front Pharmacol. 2021 Apr 28;12:679759. doi: 10.3389/fphar.2021.679759. eCollection 2021.
Leroux G, Neumann M, Meunier CF, Voisin V, Habsch I, Caron N, Michiels C, Wang L, Su BL., Alginate@TiO(2) hybrid microcapsules with high in vivo biocompatibility and stability for cell therapy, Colloids Surf B Biointerfaces. 2021 Jul;203:111770. doi: 10.1016/j.colsurfb.2021.111770. Epub 2021 Apr 16.
Juschten J, Ingelse SA, Bos LDJ, Girbes ARJ, Juffermans NP, van der Poll T, Schultz MJ, Tuinman PR; BASIC study investigators., Alkaline phosphatase in pulmonary inflammation-a translational study in ventilated critically ill patients and rats, Intensive Care Med Exp. 2020 Dec 18;8(Suppl 1):46. doi: 10.1186/s40635-020-00335-x.
Ruiz-Iglesias P, Estruel-Amades S, Camps-Bossacoma M, Massot-Cladera M, Castell M, Pérez-Cano FJ., Alterations in the mucosal immune system by a chronic exhausting exercise in Wistar rats, Sci Rep. 2020 Oct 21;10(1):17950. doi: 10.1038/s41598-020-74837-9.
Sanada TJ, Sun XQ, Happé C, Guignabert C, Tu L, Schalij I, Bogaard HJ, Goumans MJ, Kurakula K., Altered TGF?/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention, Cells. 2021 Jan 6;10(1):84. doi: 10.3390/cells10010084.
Loftén A, Adermark L, Ericson M, Söderpalm B., An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol's dopamine-releasing effect, Addict Biol. 2020 Aug 13:e12959. doi: 10.1111/adb.12959. Online ahead of print.
Kalafateli, Aimilia Lydia; Vallöf, Daniel; Colombo, Giancarlo; Lorrai, Irene; Maccioni, Paola; Jerlhag, Elisabet;, An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder. Neuropsychopharmacology, official publication of the American College of Neuropsychopharmacology Vol.44, 2019
Kalafateli AL, Satir TM, Vallöf D, Zetterberg H, Jerlhag E., An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain, Prog Neurobiol. 2020 Dec 2:101969. doi: 10.1016/j.pneurobio.2020.101969. Online ahead of print.
Kalafateli AL, Satir TM, Vallöf D, Zetterberg H, Jerlhag E., An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain, Prog Neurobiol. 2021 May;200:101969. doi: 10.1016/j.pneurobio.2020.101969. Epub 2020 Dec 2.
Nikam SP, Nettleton K, Everitt JI, Barton HA, Becker ML., Antibiotic eluting poly(ester urea) films for control of a model cardiac implantable electronic device infection, Acta Biomater. 2020 Jul 15;111:65-79. doi: 10.1016/j.actbio.2020.04.025. Epub 2020 May 22.
Juschten, Jenny; Ingelse, Sarah Anne; Maas, Martinus Adrianus Wilhelmus; Girbes, Armand Roelof Johan; Juffermans, Nicole Petra; Schultz, Marcus Josephus; Tuinman, Pieter Roel;, Antithrombin plus alpha-1 protease inhibitor does not affect coagulation and inflammation in two murine models of acute lung injury., Intensive care medicine experimental Vol.7, 2019
Tukker AM, Wijnolts FMJ, de Groot A, Westerink RHS., Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment, Toxicol Sci. 2020 Nov 1;178(1):71-87. doi: 10.1093/toxsci/kfaa136.
Le Page LM, Rider OJ, Lewis AJ, Noden V, Kerr M, Giles L, Ambrose LJA, Ball V, Mansor L, Heather LC, Tyler DJ., Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized (13) C magnetic resonance spectroscopy, NMR Biomed. 2019 Jul;32(7):e4099. doi: 10.1002/nbm.4099. Epub 2019 May 15.
Adermark L, Lagstram O, et al., Astrocytes modulate extracellular neurotransmitter levels and excitatory neurotransmission in dorsolateral striatum via dopamine D2 receptor signaling., Neuropsychopharmacology. 2021 Nov 22. doi: 10.1038/s41386-021-01232-x. [Epub ahead of print]
Callahan PM, Plagenhoef MR, Blake DT, Terry AV Jr., Atomoxetine improves memory and other components of executive function in young-adult rats and aged rhesus monkeys, Neuropharmacology. 2019 Sep 1;155:65-75. doi: 10.1016/j.neuropharm.2019.05.016. Epub 2019 May 18.
Sherman, D., Oram, T., Harel, D., & Ahissar, E. (2017)., Attention robustly gates a closed-loop touch reflex, Current Biology : CB, 27(12), 1836-1843.e7. doi:S0960-9822(17)30624-3 [pii]
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Lundberg S, Roman E, Bell RL., Behavioral Profiles of Adolescent Alcohol-Preferring/Non-preferring (P/NP) and High/Low Alcohol-Drinking (HAD/LAD) Rats Are Dependent on Line but Not Sex, Front Neurosci. 2022 Jan 13;15:811401. doi: 10.3389/fnins.2021.811401. eCollection 2021.
Parafati, M., Lascala, A., Morittu, V. M., Trimboli, F., Rizzuto, A., Brunelli, E., . . . Janda, E. (2015), Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome., The Journal of Nutritional Biochemistry, 26(9), 938-948. doi:10.1016/j.jnutbio.2015.03.008 [doi]
Brancato A, Castelli V, Lavanco G, Tringali G, Micale V, Kuchar M, D'Amico C, Pizzolanti G, Feo S, Cannizzaro C., Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity and Return., Biomedicines. 2021 Sep 4;9(9). pii: 1161. doi: 10.3390/biomedicines9091161.
Lee SJ, Krieger JP, Vergara M, Quinn D, McDougle M, de Araujo A, Darling R, Zollinger B, Anderson S, Pan A, Simonnet EJ, Pignalosa A, Arnold M, Singh A, Langhans W, Raybould HE, de Lartigue G., Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain, Cell Rep. 2020 Feb 11;30(6):2028-2039.e4. doi: 10.1016/j.celrep.2020.01.045.
Vallöf , Daniel; Kalafateli, Aimilia Lydia; Jerlhag, Elisabet;, Brain region specific glucagon-like peptide-1 receptors regulate alcohol-induced behaviors in rodents, Psychoneuroendocrinology Vol.103, 2019
Bhatta P, Dhukhwa A, Sheehan K, Al Aameri RFH, Borse V, Ghosh S, Sheth S, Mamillapalli C, Rybak L, Ramkumar V, Mukherjea D., Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea, Sci Rep. 2019 Mar 11;9(1):4131. doi: 10.1038/s41598-019-40425-9.
Vallof, D., Ulenius, L., Egecioglu, E., Engel, J. A., & Jerlhag, E. (2017)., Central administration of the anorexigenic peptide neuromedin U decreases alcohol intake and attenuates alcohol-induced reward in rodents, Addiction Biology, 22(3), 640-651. doi:10.1111/adb.12355 [doi]
Barrios V, López-Villar E, Frago LM, Canelles S, Díaz-González F, Burgos-Ramos E, Frühbeck G, Chowen JA, Argente J., Cerebral Insulin Bolus Revokes the Changes in Hepatic Lipid Metabolism Induced by Chronic Central Leptin Infusion, Cells. 2021 Mar 6;10(3):581. doi: 10.3390/cells10030581.
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Waeiss RA, Knight CP, Engleman EA, Hauser SR, Rodd ZA., Co-administration of ethanol and nicotine heightens sensitivity to ethanol reward within the nucleus accumbens (NAc) shell and increasing NAc shell BDNF is sufficient to enhance ethanol reward in naĂŻve Wistar rats, J Neurochem. 2020 Mar;152(5):556-569. doi: 10.1111/jnc.14914. Epub 2019 Dec 10.
Richards J, Miksys S, Novalen M, Tyndale RF., CYP2D in the brain impacts oral hydrocodone analgesia in vivo, Neuropharmacology. 2022 Dec 15;221:109291. doi: 10.1016/j.neuropharm.2022.109291. Epub 2022 Oct 12.
Somogyi G, Hlatky D, Spisák T, Spisák Z, Nyitrai G, Czurkó A., Deciphering the scopolamine challenge rat model by preclinical functional MRI, Sci Rep. 2021 May 25;11(1):10873. doi: 10.1038/s41598-021-90273-9.
Jackson-Cowan L, Eldahshan W, Dumanli S, Dong G, Jamil S, Abdul Y, Althomali W, Baban B, Fagan SC, Ergul A., Delayed Administration of Angiotensin Receptor (AT2R) Agonist C21 Improves Survival and Preserves Sensorimotor Outcomes in Female Diabetic Rats Post-Stroke through Modulation of Microglial Activation, Int J Mol Sci. 2021 Jan 29;22(3):1356. doi: 10.3390/ijms22031356.
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Danielsson K, Stomberg R, Adermark L, Ericson M, Söderpalm B., Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum, Transl Psychiatry. 2021 Sep 13;11(1):472. doi: 10.1038/s41398-021-01589-z.
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Schmitt MV, Reichel A, Liu X, Fricker G, Lienau P., Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat, Drug Metab Dispos. 2021 Jan;49(1):53-61. doi: 10.1124/dmd.120.000161. Epub 2020 Nov 4.
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Miguéns-Gómez A, Grau-Bové C, Sierra-Cruz M, Jorba-Martín R, Caro A, Rodríguez-Gallego E, Beltrán-Debón R, Blay MT, Terra X, Ardévol A, Pinent M., Gastrointestinally Digested Protein from the Insect Alphitobius diaperinus Stimulates a Different Intestinal Secretome than Beef or Almond, Producing a Differential Response in Food Intake in Rats, Nutrients. 2020 Aug 7;12(8):2366. doi: 10.3390/nu12082366.
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Huarte J, Espuelas S, Martínez-Oharriz C, Irache JM., Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin, Int J Pharm X. 2021 Nov 9;3:100104. doi: 10.1016/j.ijpx.2021.100104. eCollection 2021 Dec.
Renko JM, Mahato AK, Visnapuu T, Valkonen K, Karelson M, Voutilainen MH, Saarma M, Tuominen RK, Sidorova YA., Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats., J Parkinsons Dis. 2021;11(3):1023-1046. doi: 10.3233/JPD-202400.
Zhao X, Kruzel M, Ting SM, Sun G, Savitz SI, Aronowski J., Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: Pre-clinical experience, J Cereb Blood Flow Metab. 2021 Jan;41(1):53-66. doi: 10.1177/0271678X20925667. Epub 2020 May 21.
Dettori I, Gaviano L, Ugolini F, Lana D, Bulli I, Magni G, Rossi F, Giovannini MG, Pedata F., Protective Effect of Adenosine A(2B) Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat., Front Pharmacol. 2021 Feb 11;11:588757. doi: 10.3389/fphar.2020.588757. eCollection 2020.
Bigaud M, Rudolph B, Briard E, Beerli C, Hofmann A, Hermes E, Muellershausen F, Schubart A, Gardin A., Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights, Mult Scler J Exp Transl Clin. 2021 Nov 3;7(4):20552173211049168. doi: 10.1177/20552173211049168. eCollection 2021 Oct.
Swetledge S, Carter R, Stout R, Astete CE, Jung JP, Sabliov CM., Stability and ocular biodistribution of topically administered PLGA nanoparticles., Sci Rep. 2021 Jun 10;11(1):12270. doi: 10.1038/s41598-021-90792-5.
Danielsson K, et al., Subregion-specific effects on striatal neurotransmission and dopamine-signaling by acute and repeated amphetamine exposure., Neuropharmacology. 2021 Aug 15;194:108638. doi: 10.1016/j.neuropharm.2021.108638. Epub 2021 Jun 8.
Natsheh JY, Espinoza D, Bhimani S, Shiflett MW., The effects of the dopamine D2/3 agonist quinpirole on incentive value and palatability-based choice in a rodent model of attention-deficit/hyperactivity disorder., Psychopharmacology (Berl). 2021 Nov;238(11):3143-3153. doi: 10.1007/s00213-021-05931-7. Epub 2021 Jul 27.
Beatty R, Lu CE, Marzi J, Levey RE, Carvajal Berrio D, Lattanzi G, Wylie R, O'Connor R, Wallace E, Ghersi G, Salamone M, Dolan EB, Layland SL, Schenke-Layland K, Duffy GP., The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model., Tissue Eng Part C Methods. 2021 Oct;27(10):515-528. doi: 10.1089/ten.TEC.2021.0163.
Ursic, M, Babic, A, et al., The Impact of Cannabidiol on the Induction of Isoflurane Anesthesia and Recovery in Wistar Rats., Cannabis Cannabinoid Res. 2021 May 11. doi: 10.1089/can.2021.0014. [Epub ahead of print]
Brotons-Canto A, González-Navarro CJ, Gil AG, Asin-Prieto E, Saiz MJ, Llabrés JM., Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats., Pharmaceutics. 2021 Mar 9;13(3). pii: 361. doi: 10.3390/pharmaceutics13030361.
Preclinical (PK/PD)
Gustafsson Å, Wang B, Gerde P, Bergman Å, Yeung LWY., Bioavailability of inhaled or ingested PFOA adsorbed to house dust, Environ Sci Pollut Res Int. 2022 Nov;29(52):78698-78710. doi: 10.1007/s11356-022-20829-3. Epub 2022 Jun 14.
Somvanshi RK, Zou S, Kadhim S, Padania S, Hsu E, Kumar U., Cannabinol modulates neuroprotection and intraocular pressure: A potential multi-target therapeutic intervention for glaucoma, Biochim Biophys Acta Mol Basis Dis. 2022 Mar 1;1868(3):166325. doi: 10.1016/j.bbadis.2021.166325. Epub 2021 Dec 16.
Sydney-Smith JD, Koltchev AM, Moon LDF, Warren PM., Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion., Exp Neurol. 2023 Feb;360:114278. doi: 10.1016/j.expneurol.2022.114278. Epub 2022 Nov 28.
Pacławski A, Politis S, Balafas E, Mina E, Papakyriakopoulou P, Christodoulou E, Kostomitsopoulos N, Rekkas DM, Valsami G, Giovagnoli S., Development and Pharmacokinetics of a Novel Acetylsalicylic Acid Dry Powder for Pulmonary Administration, Pharmaceutics. 2022 Dec 15;14(12):2819. doi: 10.3390/pharmaceutics14122819.
Milton-Laskibar I, Cuevas-Sierra A, Portillo MP, Martínez JA., Effects of Resveratrol Administration in Liver Injury Prevention as Induced by an Obesogenic Diet: Role of Ruminococcaceae, Biomedicines. 2022 Jul 26;10(8):1797. doi: 10.3390/biomedicines10081797.
Konijnenberg LSF, Luiken TTJ, Veltien A, Uthman L, Kuster CTA, Rodwell L, de Waard GA, Kea-Te Lindert M, Akiva A, Thijssen DHJ, Nijveldt R, van Royen N., Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction, Basic Res Cardiol. 2023 Jan 13;118(1):2. doi: 10.1007/s00395-022-00974-z.
Hyppönen V, Stenroos P, Nivajärvi R, Ardenkjaer-Larsen JH, Gröhn O, Paasonen J, Kettunen MI., Metabolism of hyperpolarised [1-(13) C]pyruvate in awake and anaesthetised rat brains, NMR Biomed. 2022 Feb;35(2):e4635. doi: 10.1002/nbm.4635. Epub 2021 Oct 21.
Karsten S, Fiskesund R, Zhang XM, Marttila P, Sanjiv K, Pham T, Rasti A, Bräutigam L, Almlöf I, Marcusson-Ståhl M, Sandman C, Platzack B, Harris RA, Kalderén C, Cederbrant K, Helleday T, Warpman Berglund U., MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells, Cell Death Differ. 2022 Jan;29(1):246-261. doi: 10.1038/s41418-021-00854-4.
Ravula A, Chandasana H, Jagnarine D, Wall SC, Setlow B, Febo M, Bruijnzeel AW, Derendorf H., Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats, Cannabis Cannabinoid Res. 2019 Dec 6;4(4):240-254. doi: 10.1089/can.2019.0049. eCollection 2019.
Ravula A, Chandasana H, Setlow B, Febo M, Bruijnzeel AW, Derendorf H., Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant, J Pharm Biomed Anal. 2018 Oct 25;160:119-125. doi: 10.1016/j.jpba.2018.07.004. Epub 2018 Jul 19.
Campión R, Gonzalez-Navarro CJ, Luisa Martínez López A, Cristina Martínez-Oharriz M, Matías C, Sáiz-Abajo MJ, Collantes M, Peñuelas I, Irache JM., Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin, Int J Pharm. 2023 Aug 25;643:123216. doi: 10.1016/j.ijpharm.2023.123216. Epub 2023 Jul 8.
Surgical
Mazzini GS, Khoraki J, Browning MG, Wu J, Zhou H, Price ET, Wolfe LG, Mangino MJ, Campos GM., Gastric Bypass Increases Circulating Bile Acids and Activates Hepatic Farnesoid X Receptor (FXR) but Requires Intact Peroxisome Proliferator Activator Receptor Alpha (PPARÎą) Signaling to Significantly Reduce Liver Fat Content., J Gastrointest Surg. 2021 Apr;25(4):871-879. doi: 10.1007/s11605-021-04908-3. Epub 2021 Feb 8.
Hyppönen V, Stenroos P, Nivajärvi R, Ardenkjaer-Larsen JH, Gröhn O, Paasonen J, Kettunen MI., Metabolism of hyperpolarised [1-(13) C]pyruvate in awake and anaesthetised rat brains, NMR Biomed. 2021 Oct 21:e4635. doi: 10.1002/nbm.4635. Online ahead of print.
Ravula A, Chandasana H, Jagnarine D, Wall SC, Setlow B, Febo M, Bruijnzeel AW, Derendorf H., Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats, Cannabis Cannabinoid Res. 2019 Dec 6;4(4):240-254. doi: 10.1089/can.2019.0049. eCollection 2019.
Ravula A, Chandasana H, Setlow B, Febo M, Bruijnzeel AW, Derendorf H., Simultaneous quantification of cannabinoids tetrahydrocannabinol, cannabidiol and CB1 receptor antagonist in rat plasma: An application to characterize pharmacokinetics after passive cannabis smoke inhalation and co-administration of rimonabant, J Pharm Biomed Anal. 2018 Oct 25;160:119-125. doi: 10.1016/j.jpba.2018.07.004. Epub 2018 Jul 19.
Teratology
Pospelov AS, Ala-Kurikka T, Kurki S, Voipio J, Kaila K., Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia, Epilepsia. 2021 Aug;62(8):1971-1984. doi: 10.1111/epi.16963. Epub 2021 Jun 27.
Devonshire, I. M., Preston, M. J., Dommett, E. J., Murphy, K. L., & Greenfield, S. A. (2009), Design and evaluation of a low-cost respiratory monitoring device for use with anaesthetized animals, Laboratory Animals, 43(4), 382-389. doi:10.1258/la.2009.0080124 [doi]
Agterberg, M. J., Spoelstra, E. N., van der Wijst, S., Brakkee, J. H., Wiegant, V. M., Hamelink, R., . . . Remie, R. (2010), Evaluation of temperature rise and bonding strength in cements used for permanent head attachments in rats and mice, Laboratory Animals, 44(3), 264-270. doi:10.1258/la.2010.009083 [doi]
Nato G, Corti A, Parmigiani E, Jachetti E, Lecis D, Colombo MP, Delia D, Buffo A, Magrassi L., Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing, Sci Rep. 2021 Jan 12;11(1):651. doi: 10.1038/s41598-020-79502-9.
Clark, R. L., Edwards, T. L., Longo, M., Kinney, J., Walker, D. K., Rhodes, J., . . . Huber, A. C. (2018)., Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate, Birth Defects Research, 110(7), 553-578. doi:10.1002/bdr2.1170 [doi]
Santoro A, Scafuro M, Troisi J, Piegari G, Di Pietro P, Mele E, Cappetta D, Marino M, De Angelis A, Vecchione C, Paciello O, Fasano S, Pierantoni R, Viggiano A, Meccariello R., Multi-Systemic Alterations by Chronic Exposure to a Low Dose of Bisphenol A in Drinking Water: Effects on Inflammation and NAD(+)-Dependent Deacetylase Sirtuin1 in Lactating and Weaned Rats, Int J Mol Sci. 2021 Sep 7;22(18):9666. doi: 10.3390/ijms22189666.
Raez-Villanueva S, Debnath A, Hardy DB, Holloway AC., Prenatal nicotine exposure leads to decreased histone H3 lysine 9 (H3K9) methylation and increased p66shc expression in the neonatal pancreas., J Dev Orig Health Dis. 2021 May 28:1-5. doi: 10.1017/S2040174421000283. [Epub ahead of print]
Blesson CS, Schutt A, Chacko S, Marini JC, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli C., Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats, Front Endocrinol (Lausanne). 2019 Aug 6;10:538. doi: 10.3389/fendo.2019.00538. eCollection 2019.
Toxicology
Lina, B. A., Messinger, H., & Bar, A. (2015)., 13-week oral toxicity study of vinyl laurate in rats., Regulatory Toxicology and Pharmacology : RTP, 71(1), 101-107. doi:10.1016/j.yrtph.2014.10.015 [doi]
Morris PJ, Burke RD, Sharma AK, Lynch DC, Lemke-Boutcher LE, Mathew S, Elayan I, Rao DB, Gould TD, Zarate CA Jr, Zanos P, Moaddel R, Thomas CJ., A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801, Neurotoxicol Teratol. 2021 Sep-Oct;87:106993. doi: 10.1016/j.ntt.2021.106993. Epub 2021 May 1.
Bartnikas, T. B., Wildt, S. J., Wineinger, A. E., Schmitz-Abe, K., Markianos, K., Cooper, D. M., & Fleming, M. D. (2013)., A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2., Comparative Medicine, 63(2), 143-155.
Grandy, T. H., Greenfield, S. A., & Devonshire, I. M. (2012)., An evaluation of in vivo voltage-sensitive dyes: Pharmacological side effects and signal-to-noise ratios after effective removal of brain-pulsation artifacts., Journal of Neurophysiology, 108(11), 2931-2945. doi:10.1152/jn.00512.2011 [doi]
Salum, E., Butlin, M., Kals, J., Zilmer, M., Eha, J., Avolio, A. P., . . . Kampus, P. (2014), Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats, Diabetology & Metabolic Syndrome, 6, 57-5996-6-57. eCollection 2014. doi:10.1186/1758-5996-6-57 [doi]
Turpin, P. E., Burnett, J. E., Goodwin, L., Foster, A., & Barfield, M. (2010)., Application of the DBS methodology to a toxicokinetic study in rats and transferability of analysis between bioanalytical laboratories., Bioanalysis, 2(8), 1489-1499. doi:10.4155/bio.10.88 [doi]
Thompson CM, Brorby G, Keig-Shevlin Z, Smith R, Franzen A, Ulrich K, Blanchette AD, Doepker C., Assessment of the in vivo genotoxic potential of three smoke flavoring primary product mixtures., Environ Mol Mutagen. 2023 Oct-Nov;64(8-9):420-431. doi: 10.1002/em.22576. Epub 2023 Nov 30.
Silva AV, Norinder U, Liiv E, Platzack B, Öberg M, Törnqvist E., Associations between clinical signs and pathological findings in toxicity testing, ALTEX. 2020 Oct 26. doi: 10.14573/altex.2003311. Online ahead of print.
Barragin-Zarate GS, Alexander-Aguilera A, et al., Bioactive compounds from Prosthechea karwinskii decrease obesity, insulin resistance, pro-inflammatory status, and cardiovascular risk in Wistar rats with metabolic syndrome., J Ethnopharmacol. 2021 Oct 28;279:114376. doi: 10.1016/j.jep.2021.114376. Epub 2021 Jun 25.
Zuurbier, C. J., Heinen, A., Koeman, A., Stuifbergen, R., Hakvoort, T. B., Weber, N. C., & Hollmann, M. W. (2014)., Cardioprotective efficacy depends critically on pharmacological dose, duration of ischaemia, health status of animals and choice of anaesthetic regimen: A case study with folic acid., Journal of Translational Medicine, 12, 325-014-0325-8. doi:10.1186/s12967-014-0325-8 [doi]
Rodd ZA, Engleman EA, Truitt WA, Burke AR, Molosh AI, Bell RL, Hauser SR., CNO Administration Increases Dopamine and Glutamate in the Medial Prefrontal Cortex of Wistar Rats: Further Concerns for the Validity of the CNO-activated DREADD Procedure, Neuroscience. 2022 May 21;491:176-184. doi: 10.1016/j.neuroscience.2022.03.028. Epub 2022 Mar 26.
Hall, A. P., Davies, W., Stamp, K., Clamp, I., & Bigley, A. (2013), Comparison of computerized image analysis with traditional semiquantitative scoring of perls' prussian blue stained hepatic iron deposition., Toxicologic Pathology, 41(7), 992-1000. doi:10.1177/0192623313476576 [doi]
Roques, B. B., Lacroix, M. Z., Puel, S., Gayrard, V., Picard-Hagen, N., Jouanin, I., . . . Viguie, C. (2012)., CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats., Toxicological Sciences : An Official Journal of the Society of Toxicology, 127(1), 29-41. doi:10.1093/toxsci/kfs094 [doi]
Harris, Stephen B; Hardisty, Jerry F; Hayes, A Wallace; Weber, Klaus;, Developmental and reproductive toxicity studies of BIA 10-2474, Regulatory toxicology and pharmacology : RTP Vol., 2019
Harris SB, Hardisty JF, Hayes AW, Weber K., Developmental and reproductive toxicity studies of BIA 10-2474, Regul Toxicol Pharmacol. 2020 Mar;111:104543. doi: 10.1016/j.yrtph.2019.104543. Epub 2019 Nov 20.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE., Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats, Clin Toxicol (Phila). 2021 Jul 19:1-8. doi: 10.1080/15563650.2021.1953049. Online ahead of print.
Panknin O, Wagenfeld A, Bone W, Bender E, Nowak-Reppel K, Fernández-Montalván AE, Nubbemeyer R, Bäurle S, Ring S, Schmees N, Prien O, Schäfer M, Friedrich C, Zollner TM, Steinmeyer A, Mueller T, Langer G., Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women, J Med Chem. 2020 Oct 22;63(20):11854-11881. doi: 10.1021/acs.jmedchem.0c01076. Epub 2020 Oct 6.
Finlay, M. R., Anderton, M., Ashton, S., Ballard, P., Bethel, P. A., Box, M. R., . . . Wrigley, G. L. (2014)., Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor., Journal of Medicinal Chemistry, 57(20), 8249-8267. doi:10.1021/jm500973a [doi]
Bisson, J. F., Daubie, S., Hidalgo, S., Guillemet, D., & Linares, E. (2010)., Diuretic and antioxidant effects of cacti-nea, a dehydrated water extract from prickly pear fruit, in rats, Phytotherapy Research : PTR, 24(4), 587-594. doi:10.1002/ptr.2996 [doi]
Fennell, T. R., Snyder, R., Hansen, B., & Friedman, M. (2015)., Dosimetry of acrylamide and glycidamide over the lifespan in a 2-year bioassay of acrylamide in wistar han rats, Toxicological Sciences : An Official Journal of the Society of Toxicology, 146(2), 386-394. doi:10.1093/toxsci/kfv104 [doi]
Fennell, T. R., Snyder, R., Hansen, B., & Friedman, M. (2015)., Dosimetry of acrylamide and glycidamide over the lifespan in a 2-year bioassay of acrylamide in wistar han rats., Toxicological Sciences : An Official Journal of the Society of Toxicology, 146(2), 386-394. doi:10.1093/toxsci/kfv104 [doi]
Klose, M., Grote, K., Spathmann, O., Streckert, J., Clemens, M., Hansen, V. W., & Lerchl, A. (2014)., Effects of early-onset radiofrequency electromagnetic field exposure (GSM 900 MHz) on behavior and memory in rats., Radiation Research, 182(4), 435-447. doi:10.1667/RR13695.1 [doi]
Scott H, Tjernström N, Roman E., Effects of pair housing on voluntary alcohol intake in male and female Wistar rats, Alcohol. 2020 Aug;86:121-128. doi: 10.1016/j.alcohol.2019.12.005. Epub 2020 Jan 21.
Devonshire, I. M., Grandy, T. H., Dommett, E. J., & Greenfield, S. A. (2010), Effects of urethane anaesthesia on sensory processing in the rat barrel cortex revealed by combined optical imaging and electrophysiology., The European Journal of Neuroscience, 32(5), 786-797. doi:10.1111/j.1460-9568.2010.07322.x [doi]
Cupi D, Thorsen M, Elvig-Jørgensen SG, Wulf-Andersen L, Berti-Sorbara JO, J Cowieson A, Faruk MU., Efficacy and safety profile of a subtilisin protease produced by fermentation in Bacillus licheniformis to be used as a feed additive, Heliyon. 2022 Aug 2;8(8):e10030. doi: 10.1016/j.heliyon.2022.e10030. eCollection 2022 Aug.
Sangaraju D, Katavolos P, Liang X, Chou C, Zabka TS, Dean B, Maher J., Establishment of baseline profiles of 50 bile acids in preclinical toxicity species: A comprehensive assessment of translational differences and study design considerations for biomarker development, Toxicol Appl Pharmacol. 2022 May 15;443:116008. doi: 10.1016/j.taap.2022.116008. Epub 2022 Apr 1.
Verma, R., Kushwah, L., Gohel, D., Patel, M., Marvania, T., & Balakrishnan, S. (2013)., Evaluating the ameliorative potential of quercetin against the bleomycin-induced pulmonary fibrosis in wistar rats., Pulmonary Medicine, 2013, 921724. doi:10.1155/2013/921724 [doi]
Verma, R., Brahmankar, M., Kushwah, L., & Suresh, B. (2013)., Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats., Environmental Toxicology and Pharmacology, 36(3), 769-778. doi:10.1016/j.etap.2013.07.011 [doi]
Daga M, de Graaf IAM, Argenziano M, Barranco ASM, Loeck M, Al-Adwi Y, Cucci MA, Caldera F, Trotta F, Barrera G, Casini A, Cavalli R, Pizzimenti S., Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver, Toxicol In Vitro. 2020 Jun;65:104800. doi: 10.1016/j.tiv.2020.104800. Epub 2020 Feb 19.
Jamison Courtney N, Cuevas-Ocampo Areli K, Flowers Ashley B, Nam Hyung W, Dayton Robert D, McKinney Mary P, Mitchell Hannah G, Fitzgerald Joseph S, Steib Mattie E, Toups Colton R, McMartin Kenneth E., Histopathological evidence that diethylene glycol produces kidney and nervous system damage in rats, Neurotoxicology. 2022 Jul;91:200-210. doi: 10.1016/j.neuro.2022.05.015. Epub 2022 May 25.
Tulinska, J., Adel-Patient, K., Bernard, H., Liskova, A., Kuricova, M., Ilavska, S., . . . Steinberg, P. (2018)., Humoral and cellular immune response in wistar han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th framework programme project GRACE)., Archives of Toxicology, 92(7), 2385-2399. doi:10.1007/s00204-018-2230-z [doi]
Karp NA, Coleman L, Cotton P, Powles-Glover N, Wilson A., Impact of repeated micro and macro blood sampling on clinical chemistry and haematology in rats for toxicokinetic studies., Regul Toxicol Pharmacol. 2023 Jun;141:105386. doi: 10.1016/j.yrtph.2023.105386. Epub 2023 Apr 20.
Masuda-Herrera, Melisa J; Dobo, Krista L; Kenyon, Michelle O; Kenny, Julia D; Galloway, Sheila M; Escobar, Patricia A; Reddy, M Vijayaraj; Jolly, Robert A; Trejo-Martin, Alejandra; Brown, Caren; Mckeon, Marie; Young, Megan; Bruce, Shannon; Pant, Kamala; Dutta, Aparajita; Kulkarni, Rohan; Bercu, Joel P, In Vivo Mutagenicity Testing of Arylboronic Acids and Esters., Environmental and molecular mutagenesis Vol.60, 2019
Cloup E, Romao P, Taylor I, Mowat V, Mukaratirwa S., Incidences and Range of Spontaneous Microscopic Lesions in the Eye of Sprague-Dawley Rats and Han Wistar Rats Used in Toxicity Studies, Toxicol Pathol. 2021 Apr;49(3):581-589. doi: 10.1177/0192623320951474. Epub 2020 Aug 25.
Dietrich, H., & Jenck, F. (2010)., Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant., Psychopharmacology, 212(2), 145-154. doi:10.1007/s00213-010-1933-5 [doi]
Steinberg, Pablo; van der Voet, Hilko; Goedhart, Paul W; Kleter, Gijs; Kok, Esther J; Pla, Maria; Nadal, Anna; ZeljenkovĂĄ, Dagmar; AlĂĄ?ovĂĄ, Radka; BabincovĂĄ, JĂşlia; RollerovĂĄ, Eva; Ja?u?ovĂĄ, So?a; Kebis, Anton; Szabova, Elena; TulinskĂĄ, Jana; LĂĹĄkovĂĄ, AurĂŠlia; TakĂĄcsovĂĄ, Melinda; MikuĹĄovĂĄ, Miroslava LehotskĂĄ; KrivoĹĄĂkovĂĄ, Zora; SpĂśk, Armin; Racovita, Monica; de Vriend, Huib; Alison, Roger; Alison, Clare; Baumgärtner, Wolfgang; Becker, Kathrin; Lempp, Charlotte; Schmicke, Marion; Schrenk, Dieter; PĂśting, Annette; Schiemann, Joachim; Wilhelm, Ralf;, Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats., Archives of toxicology Vol.93, 2019
Weber, K., Germann, P. G., Iwata, H., Hardisty, J., Kaufmann, W., & Rosenbruch, M. (2009)., Lesions in the larynx of wistar RccHan: WIST rats, Journal of Toxicologic Pathology, 22(4), 229-246. doi:10.1293/tox.22.229 [doi]
Pothmann, D., Simar, S., Schuler, D., Dony, E., Gaering, S., Le Net, J. L., . . . Regnier, J. F. (2015), Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes graphistrength((c)) C100 after a 90-day nose-only inhalation exposure of rats., Particle and Fibre Toxicology, 12, 21-015-0096-2. doi:10.1186/s12989-015-0096-2 [doi]
Gregori M, Naylor SW, Freke MC, Chamanza R, Piaia A, Hall AP., Multisite Analysis of Lesions in the Respiratory Tract of the Rat and Nonhuman Primate (Cynomolgus Monkey) Exposed to Air, Vehicle, and Inhaled Small Molecule Compounds, Toxicol Pathol. 2020 Nov 10:192623320953839. doi: 10.1177/0192623320953839. Online ahead of print.
Bergner, R., Siegrist, B., Gretz, N., Pohlmeyer-Esch, G., & Kranzlin, B. (2015)., Nephrotoxicity of ibandronate and zoledronate in wistar rats with normal renal function and after unilateral nephrectomy., Pharmacological Research : The Official Journal of the Italian Pharmacological Society, 99, 16-22. doi:S1043-6618(15)00085-7 [pii]
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE., Neurotoxic effects of nephrotoxic compound diethylene glycol, Clin Toxicol (Phila). 2021 Sep;59(9):810-821. doi: 10.1080/15563650.2021.1874403. Epub 2021 Jan 21.
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