Rhesus macaque

Related publications

COVID-19

Baisa G, Rancour D, Mansfield K, Burns M, Martin L, Cunha D, Fischer J, Muecksch F, Hatziioannou T, Bieniasz P, Schomburg F, Luke K., A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques, bioRxiv. 2020 Dec 21:2020.12.20.422693. doi: 10.1101/2020.12.20.422693. Preprint.

Liu Y, Garron TM, Chang Q, Su Z, Zhou C, Gong EC, Zheng J, Yin Y, Ksiazek T, Brasel T, Jin Y, Boor P, Comer JE, Gong B., Cell-type apoptosis in lung during SARS-CoV-2 infection, bioRxiv. 2020 Dec 24:2020.12.23.424254. doi: 10.1101/2020.12.23.424254. Preprint.

Liu, Y., Garron, T. M., Chang, Q., Su, Z., Zhou, C., Qiu, Y., ... & Gong, B., Cell-Type Apoptosis in Lung during SARS-CoV-2 Infection, Pathogens 10, no. 5 (2021): 509.

Diabetes

Kenyon, N S; Chatzipetrou, M; Masetti, M; Ranuncoli, A; Oliveira, M; Wagner, J L; Kirk, A D; Harlan, D M; Burkly, L C; Ricordi, C;, Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154., Proceedings of the National Academy of Sciences of the United States of America Vol.96, 1999

Lebherz, Corinna; Maguire, Albert M; Auricchio, Alberto; Tang, Waixing; Aleman, Tomas S; Wei, Zhangyong; Grant, Rebecca; Cideciyan, Artur V; Jacobson, Samuel G; Wilson, James M; Bennett, Jean;, Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor., Diabetes Vol.54, 2005

Andrades, P; Asiedu, C K; Gansuvd, B; Inusah, S; Goodwin, K J; Deckard, L A; Jargal, U; Thomas, J M;, Pancreatic islet isolation variables in non-human primates (rhesus macaques)., Diabetologia Vol.51, 2008

General studies

Bonizzato M, Autonomous optimization of neuroprosthetic stimulation parameters that drive the motor cortex and spinal cord outputs in rats and monkeys, Cell Rep Med. 2023 Apr 18;4(4):101008. doi: 10.1016/j.xcrm.2023.101008. Epub 2023 Apr 11.

Immunology

Edens C, Collins ML, Goodson JL, Rota PA, Prausnitz MR, A microneedle patch containing measles vaccine is immunogenic in non-human primates, Vaccine. 2015 Sep 8;33(37):4712-8.

Greig JA, Calcedo R, Kuri-Cervantes L, Nordin JML, Albrecht J, Bote E, Goode T, Chroscinski EA, Bell P, Richman LK, Betts MR, Wilson JM, AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver, Mol Ther Methods Clin Dev. 2018 Dec 5;11:191-201

Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, LorĂŠ K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G., Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition., Nat Med. 2016 Jul;22(7):762-70.

Tas JMJ, Koo JH, Lin YC, Xie Z, Steichen JM, Jackson AM, Hauser BM, Wang X, Cottrell CA, Torres JL, Warner JE, Kirsch KH, Weldon SR, Groschel B, Nogal B, Ozorowski G, Bangaru S, Phelps N, Adachi Y, Eskandarzadeh S, Kubitz M, Burton DR, Lingwood D, Schmidt AG, Nair U, Ward AB, Schief WR, Batista FD., Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses, Immunity. 2022 Oct 11;55(10):1856-1871.e6. doi: 10.1016/j.immuni.2022.07.020. Epub 2022 Aug 4.

Dearing J, Conte A, Brooks C, Zimina A, Rivas R, Birch SM…Vermillion SM, Characterization of enterovirus D68 infection in four nonhuman primate species, bioRxiv 2022.04.16.487524

Andres-Mateos E, Landegger LD, Unzu C, Phillips J, Lin BM, Dewyer NA, Sanmiguel J, Nicolaou F, Valero MD, Bourdeu KI, Sewell WF, Beiler RJ, McKenna MJ, Stankovic KM, Vandenberghe LH., Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate., Nat Commun. 2022 Mar 15;13(1):1359. doi: 10.1038/s41467-022-28969-3.

Alfson, K. J., Goez-Gazi, Y., Gazi, M., Staples, H., Mattix, M., Ticer, A., ... & Carrion, R., Development of a Well-Characterized Rhesus Macaque Model of Ebola Virus Disease for Support of Product Development, Microorganisms 9, no. 3 (2021): 489.

Kielau Kisalu N, Da Silva Pereira L, Ernste KJ, Flores-Garcia Y, Idris AH, Asokan M, Dillon M, MacDonald S, Shi W, Chen X, Pegu A, SchĂśn A, Zavala F, Balazs AB, Francica JR, Seder RA., Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention, JCI Insight. 2020 Dec 17:143958. doi: 10.1172/jci.insight.143958. Online ahead of print.

Perez Cuevas MB, Kodani M, Choi Y, Joyce J, O'Connor SM, Kamili S, Prausnitz MR., Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques., Bioeng Transl Med. 2018 Aug 27;3(3):186-196

Liu G, Song L, Beasley DW, Putnak R, Parent J, Misczak J, Li H, Reiserova L, Liu X, Tian H, Liu W, Labonte D, Duan L, Kim Y, Travalent L, Wigington D, Weaver B, Tussey L., Immunogenicity and efficacy of flagellin-envelope fusion dengue vaccines in mice and monkeys., Clin Vaccine Immunol. 2015 May;22(5):516-25.

McCracken MK, Gromowski GD, Friberg HL, Lin X, Abbink P, De La Barrera R, Eckles KH, Garver LS, Boyd M, Jetton D, Barouch DH, Wise MC, Lewis BS, Currier JR, Modjarrad K, Milazzo M, Liu M, Mullins AB, Putnak JR, Michael NL, Jarman RG, Thomas SJ, Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques., PLoS Pathog. 2017 Aug 3;13(8):e1006487.

Bukh I, Calcedo R, Roy S, Carnathan DG, Grant R, Qin Q, Boyd S, Ratcliffe SJ, Veeder CL, Bellamy SL, Betts MR, Wilson JM., Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector., J Virol. 2014 Aug;88(15):8468-78.

Horiuchi M, Hinderer CJ, Greig JA, Dyer C, Buza EL, Bell P, Chichester JA, Hayashi PM, Yan H, Goode T, Wilson JM., Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors, Mol Ther Methods Clin Dev. 2022 Oct 4;27:272-280. doi: 10.1016/j.omtm.2022.09.017. eCollection 2022 Dec 8.

Vidal SJ, Bekerman E, Hansen D, Lu B, Wang K, Mwangi J, Rowe W, Campigotto F, Zheng J, Kato D, Chandrashekar A, Barrett J, Patel S, Wan H, Anioke T, Mercado NB, Nkolola JP, Ferguson MJ, Rinaldi WJ, Callebaut C, Blair W, Cihlar T, Geleziunas R, Yant SR, Barouch DH., Long-acting capsid inhibitor protects macaques from repeat SHIV challenges, Nature. 2022 Jan;601(7894):612-616. doi: 10.1038/s41586-021-04279-4. Epub 2021 Dec 7.

Greig JA, Brenton C, Martins KM, Zhu Y, He Z, White J...Wilson JM, Loss of transgene expression limits liver gene therapy in primates, bioRxiv 2022.03.24.485675

Spitsin S, Schnepp BC, Connell MJ, Liu T, Dang CM, Pappa V, Tustin R, Kinder A, Johnson PR, Douglas SD., Protection against SIV in Rhesus Macaques Using Albumin and CD4-Based Vector-Mediated Gene Transfer, Mol Ther Methods Clin Dev. 2020 May 8;17:1088-1096. doi: 10.1016/j.omtm.2020.04.019. eCollection 2020 Jun 12.

Pahar B, Gray W, Fahlberg M, Grasperge B, Hunter M, Das A, Mabee C, Aye PP, Schiro F, Hensley K, Ratnayake A, Goff K, LaBranche C, Shen X, Tomaras GD, DeMarco CT, Montefiori D, Kissinger P, Marx PA, Traina-Dorge V., Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques, Viruses. 2022 Dec 17;14(12):2819. doi: 10.3390/v14122819.

Blackburn MJ, Zhong-Min M, Caccuri F, McKinnon K, Schifanella L, Guan Y, Gorini G, Venzon D, Fenizia C, Binello N, Gordon SN, Miller CJ, Franchini G, Vaccari M, Regulatory and Helper Follicular T Cells and Antibody Avidity to Simian Immunodeficiency Virus Glycoprotein 120, J Immunol. 2015 Oct 1;195(7):3227-36.

Gach JS, Venzon D, Vaccari M, Keele BF, Franchini G, Forthal DN., Relationship between Vaccine-Induced Antibody Capture of Infectious Virus and Infection Outcomes following Repeated Low-Dose Rectal Challenges with Simian Immunodeficiency Virus SIVmac251., . J Virol. 2016 Sep 12;90(19):8487-95

McCracken MK, Gromowski GD, Garver LS, Goupil BA, Walker KD, Friberg H, Currier JR, Rutvisuttinunt W, Hinton KL, Christofferson RC, Mores CN, Vanloubbeeck Y, Lorin C, Malice MP, Thomas SJ, Jarman RG, Vaughn DW, Putnak JR, Warter L., Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques, PLoS Negl Trop Dis. 2020 Apr 8;14(4):e0008191. doi: 10.1371/journal.pntd.0008191. eCollection 2020 Apr.

Brody IB, Calcedo R, Connell MJ, Carnathan DG, Nason M, Lawson BO, Nega MT, Boyd S, Qin Q, Vanderford TH, Wilson JM, Wilson JM, Silvestri G, Betts MR., Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model., Pathog Immun. 2019 Jan 29;4(1):1-20

Vaccari M, Fenizia C, Ma ZM, Hryniewicz A, Boasso A, Doster MN, Miller CJ, Lindegardh N, Tarning J, Landay AL, Shearer GM, Franchini G., Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques., AIDS Res Hum Retroviruses. 2014 Apr;30(4):355-62.

Greig JA, Breton C, Ashley SN, Martins KM, Gorsuch C, Chorazeczewski JK, Furmanak T, Smith MK, Zhu Y, Bell P, Shoop W, Li H, Smith J, Tomberlin G, Clark P, Mitchell TW, Buza EL, Yan H, Jantz D, Wilson JM. , Treating Transthyretin Amyloidosis via Adeno-Associated Virus Vector Delivery of Meganucleases., Hum Gene Ther. 2022 Nov;33(21-22):1174-1186. doi: 10.1089/hum.2022.061.

Vang, L., Morello, C. S., Mendy, J., Thompson, D., Manayani, D., Guenther, B., ... & Alexander, J., Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus, PLoS neglected tropical diseases 15, no. 3 (2021): e0009195.

Infectious disease

Goethals O, Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates, Nature. 2023 Mar;615(7953):678-686. doi: 10.1038/s41586-023-05790-6. Epub 2023 Mar 15.

Rahman MA, Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIV(mac251) acquisition in macaques, Front Immunol. 2023 Apr 21;14:1139402. doi: 10.3389/fimmu.2023.1139402. eCollection 2023.

Triplett C, Dufek S, Niemuth N, Kobs D, Cirimotich C, Mack K, Sanford D, Onset and Progression of Infection Based on Viral Loads in Rhesus Macaques Exposed to Zika Virus, Applied Microbiology. 2022; 2(3):544-553. https://doi.org/10.3390/applmicrobiol2030042

Neuroscience

Qiao S, Sedillo JI, Brown KA, Ferrentino B, Pesaran B., A Causal Network Analysis of Neuromodulation in the Mood Processing Network, Neuron. 2020 Sep 9;107(5):972-985.e6. doi: 10.1016/j.neuron.2020.06.012. Epub 2020 Jul 8.

Obesity

Blalock, Eric M; Grondin, Richard; Chen, Kuey-chu; Thibault, Olivier; Thibault, Veronique; Pandya, Jignesh D; Dowling, Amy; Zhang, Zhiming; Sullivan, Patrick; Porter, Nada M; Landfield, Philip W;, Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys, The Journal of neuroscience : the official journal of the Society for Neuroscience Vol.30, 2010

Pharmacology

Ngwenya, Laura B; Heyworth, Nadine C; Shwe, Yamin; Moore, Tara L; Rosene, Douglas L;, Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey., Frontiers in systems neuroscience Vol.9, 2015

Xu, Rui; Jia, Ying; Zygmunt, Deborah A; Cramer, Megan L; Crowe, Kelly E; Shao, Guohong; Maki, Agatha E; Guggenheim, Haley N; Hood, Benjamin C; Griffin, Danielle A; Peterson, Ellyn; Bolon, Brad; Cheatham, John P; Cheatham, Sharon L; Flanigan, Kevin M; Rodino-Klapac, Louise R; Chicoine, Louis G; Martin, Paul T;, An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK.GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque. Molecular therapy., Methods & clinical development Vol.10, 2018

Kundu, Mila C; Ringenberg, Michael A; d'Epagnier, Denise L; Haag, Heather L; Maguire, Sean;, Coccidioidomycosis in an Indoor-housed Rhesus Macaque (Macaca mulatta)., Comparative medicine Vol.67, 2017

Boado, Ruben J; Pardridge, William M;, Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey., Drug metabolism and disposition: the biological fate of chemicals Vol.37, 2009

Fan, Xiaotong; Nelson, Brian D; Ai, Yi; Stiles, David K; Gash, Don M; Hardy, Peter A; Zhang, Zhiming;, Continuous intraputamenal convection-enhanced delivery in adult rhesus macaques., Journal of neurosurgery Vol.123, 2015

Cheleuitte-Nieves CE, Diaz LL, Pardos de la Gandara M, Gonzalez A, Freiwald WA, de Lencastre HM, Tomasz A, Euler CW., Evaluation of Topical Lysostaphin as a Novel Treatment for Instrumented Rhesus Macaques (Macaca mulatta) Infected with Methicillin-Resistant Staphylococcus aureus, Comp Med. 2020 Oct 1;70(5):335-347. doi: 10.30802/AALAS-CM-19-000102. Epub 2020 Aug 13.

Dorman, David C; Struve, Melanie F; Norris, Amy; Higgins, Alan J, Metabolomic analyses of body fluids after subchronic manganese inhalation in rhesus monkeys., Toxicological sciences : an official journal of the Society of Toxicology Vol.106, 2008

Stenslik, M J; Evans, A; Pomerleau, F; Weeks, R; Huettl, P; Foreman, E; Turchan-Cholewo, J; Andersen, A; Cass, W A; Zhang, Z; Grondin, R C; Gash, D M; Gerhardt, G A; Bradley, L H, Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques., Journal of neuroscience methods Vol.303, 2018

Grondin, Richard; Ge, Pei; Chen, Qingmin; Sutherland, Jessica E; Zhang, Zhiming; Gash, Don M; Stiles, David K; Stewart, Gregory R; Sah, Dinah W Y; Kaemmerer, William F;, Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA., Molecular therapy. Nucleic acids Vol.4, 2015

Maguire DR, Gerak LR, Cami-Kobeci G, Husbands SM, France CP, Belli B, Flynn P., OREX-1019: A Novel Treatment of Opioid Use Disorder and Relapse Prevention, J Pharmacol Exp Ther. 2020 Feb;372(2):205-215. doi: 10.1124/jpet.119.261511. Epub 2019 Nov 20.

Lu S, Haskali MB, Ruley KM, Dreyfus NJ, DuBois SL, Paul S, Liow JS, Morse CL, Kowalski A, Gladding RL, Gilmore J, Mogg AJ, Morin SM, Lindsay-Scott PJ, Ruble JC, Kant NA, Shcherbinin S, Barth VN, Johnson MP, Cuadrado M, Jambrina E, Mannes AJ, Nuthall HN, Zoghbi SS, Jesudason CD, Innis RB, Pike VW., PET ligands [ 18 F]LSN3316612 and [ 11 C]LSN3316612 quantify O-linked-Î˛- N-acetyl-glucosamine hydrolase in the brain, Sci Transl Med. 2020 May 13;12(543):eaau2939. doi: 10.1126/scitranslmed.aau2939.

Stephens, Michelle L; Pomerleau, Francois; Huettl, Peter; Gerhardt, Greg A; Zhang, Zhiming;, Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype, Journal of neuroscience methods Vol.185, 2010

Maiello, Pauline; DiFazio, Robert M; Cadena, Anthony M; Rodgers, Mark A; Lin, Philana Ling; Scanga, Charles A; Flynn, JoAnne L;, Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison., Infection and immunity Vol.86, 2018

Grondin, Richard; Kaytor, Michael D; Ai, Yi; Nelson, Peter T; Thakker, Deepak R; Heisel, Jennifer; Weatherspoon, Marcy R; Blum, Janelle L; Burright, Eric N; Zhang, Zhiming; Kaemmerer, William F;, Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum., Brain : a journal of neurology Vol.135, 2012

Quintero, J E; Ai, Yi; Andersen, A H; Hardy, P; Grondin, R; Guduru, Z; Gash, D M; Gerhardt, G A; Zhang, Z;, Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques., Clinical Vol.22, 2019

Toxicology

Hinderer C, Miller R, Dyer C, Johansson J, Bell P, Buza E, Wilson JM., Adeno-associated virus serotype 1-based gene therapy for FTD caused by GRN mutations, Ann Clin Transl Neurol. 2020 Oct;7(10):1843-1853. doi: 10.1002/acn3.51165. Epub 2020 Sep 16.

Hordeaux J, Buza EL, Dyer C, Goode T, Mitchell TW, Richman L, Denton N, Hinderer C, Katz N, Schmid R, Miller R, Choudhury GR, Horiuchi M, Nambiar K, Yan H, Li M, Wilson JM., Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology, Hum Gene Ther. 2020 Aug;31(15-16):808-818. doi: 10.1089/hum.2020.167. Epub 2020 Jul 31.

Pettiglio, Michael A; Herrera, Carolina; Foster, Melanie L; Dorman, David C; Bartnikas, Thomas B;, Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure, Data in brief Vol.6, 2016

Vellichirammal NN, Sethi S, Pandey S, Singh J, Wise SY, Carpenter AD, Fatanmi OO, Guda C, Singh VK., Lung transcriptome of nonhuman primates exposed to total- and partial-body irradiation., Mol Ther Nucleic Acids. 2022 Aug 4;29:584-598. doi: 10.1016/j.omtn.2022.08.006.

Hordeaux J, Buza EL, Jeffrey B, Song C, Jahan T, Yuan Y, Zhu Y, Bell P, Li M, Chichester JA, Calcedo R, Wilson JM., MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates, Sci Transl Med. 2020 Nov 11;12(569):eaba9188. doi: 10.1126/scitranslmed.aba9188.

E Quintero J, Zhang R, Pang Q, Xing Y, Hardy P, Fan X, Ai Y, Gash DM, A Gerhardt G, Grondin R, Zhang Z., Surgical methodology and protocols for preventing implanted cerebral catheters from becoming obstructed during and after neurosurgery, J Neurosci Methods. 2021 Feb 1;349:109020. doi: 10.1016/j.jneumeth.2020.109020. Epub 2020 Dec 4.

Hordeaux, Juliette; Hinderer, Christian; Goode, Tamara; Katz, Nathan; Buza, Elizabeth L; Bell, Peter; Calcedo, Roberto; Richman, Laura K; Wilson, James M;, Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Human Alpha-L-Iduronidase in Rhesus Macaques., Molecular therapy. Methods & clinical development Vol.10, 2018

Hordeaux, Juliette; Hinderer, Christian; Goode, Tamara; Buza, Elizabeth L; Bell, Peter; Calcedo, Roberto; Richman, Laura K; Wilson, James M;, Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Iduronate-2-Sulfatase in Rhesus Macaques. Molecular therapy., Methods & clinical development Vol.10, 2018

Transplantation

Pathiraja, V; Villani, V; Tasaki, M; Matar, A J; Duran-Struuck, R; Yamada, R; Moran, S G; Clayman, E S; Hanekamp, J; Shimizu, A; Sachs, D H; Huang, C A; Yamada, K;, Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys., American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Vol.17, 2017