MeCP2 knockout rats
Related publications
Neuroscience
Wu Y, Zhong W, Cui N, Johnson CM, Xing H, Zhang S, Jiang C., Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats., J Neurodev Disord. 2016 Jun 16;8:23.
Engineer CT, Rahebi KC, Borland MS, Buell EP, Centanni TM, Fink MK, Im KW, Wilson LG, Kilgard MP., Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome., Neurobiol Dis. 2015 Nov;83:26-34.
Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC., Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome., Hum Mol Genet. 2016 Aug 1;25(15):3284-3302.
Patterson KC, Hawkins VE, Arps KM, Mulkey DK, Olsen ML., MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats., Hum Mol Genet. 2016 Aug 1;25(15):3303-3320.
Wu Y, Cui N, Xing H, Zhong W, Arrowood C, Johnson CM, Jiang C., Mecp2 Disruption in Rats Causes Reshaping in Firing Activity and Patterns of Brainstem Respiratory Neurons., Neuroscience. 2019 Jan 15;397:107-115.
Bhattacherjee A, Winter MK, Eggimann LS, Mu Y, Gunewardena S, Liao Z, Christianson JA, Smith PG., Motor, Somatosensory, Viscerosensory and Metabolic Impairments in a Heterozygous Female Rat Model of Rett Syndrome., Int J Mol Sci. 2017 Dec 29;19(1). pii: E97
Rett syndrome
Li, J., Kells, P.A., Osgood, A.C., Gautam, S.H. and Shew, W.L., Collapse of complexity of brain and body activity due to excessive inhibition and MeCP2 disruption, Proceedings of the National Academy of Sciences 118, no. 43 (2021).
Adcock KS, Blount AE, Morrison RA, Alvarez-Dieppa A, Kilgard MP, Engineer CT, Hays SA., Deficits in skilled motor and auditory learning in a rat model of Rett syndrome, J Neurodev Disord. 2020 Sep 28;12(1):27. doi: 10.1186/s11689-020-09330-5.
Gallucci, A., Patterson, K. C., Weit, A. R., Van Der Pol, W. J., Dubois, L. G., Percy, A. K., ... & Olsen, M. L., Microbial community changes in a female rat model of Rett syndrome, Progress in Neuro-Psychopharmacology and Biological Psychiatry 109 (2021): 110259.
Murasawa H, Kobayashi H, Imai J, Nagase T, Soumiya H, Fukumitsu H, Substantial acetylcholine reduction in multiple brain regions of Mecp2-deficient female rats and associated behavioral abnormalities, PLoS ONE 16(10): e0258830. 2021.
Adcock KS, Chandler C, Buell EP, Solorzano BR, Loerwald KW, Borland MS, Engineer CT., Vagus nerve stimulation paired with tones restores auditory processing in a rat model of Rett syndrome, Brain Stimul. 2020 Nov-Dec;13(6):1494-1503. doi: 10.1016/j.brs.2020.08.006. Epub 2020 Aug 12.
