Lrrk2 knockout rats
Related publications
Neuroscience
Daher JP, Volpicelli-Daley LA, Blackburn JP, Moehle MS, West AB., Abrogation of Îą-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats., Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94.
Creed RB, Menalled L, Casey B, Dave KD, Janssens HB, Veinbergs I, van der Hart M, Rassoulpour A, Goldberg MS., Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum., Neuroscience. 2019 Jun 15;409:169-179.
Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL., Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies., Biochem J. 2013 Jul 1;453(1):101-13.
West AB, Cowell RM, Daher JP, Moehle MS, Hinkle KM, Melrose HL, Standaert DG, Volpicelli-Daley LA., Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents., J Comp Neurol. 2014 Aug 1;522(11):2465-80.
Baptista MA, Dave KD, Frasier MA, Sherer TB, Greeley M, Beck MJ, Varsho JS, Parker GA, Moore C, Churchill MJ, Meshul CK, Fiske BK., Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs., PLoS One. 2013 Nov 14;8(11):e80705.
Bae EJ, Kim DK, Kim C, Mante M, Adame A, Rockenstein E, Ulusoy A, Klinkenberg M, Jeong GR, Bae JR, Lee C, Lee HJ, Lee BD, Di Monte DA, Masliah E, Lee SJ., LRRK2 kinase regulates Îą-synuclein propagation via RAB35 phosphorylation., Nat Commun. 2018 Aug 27;9(1):3465.
Andersen MA, Christensen KV, Badolo L, Smith GP, Jeggo R, Jensen PH, Andersen KJ, Sotty F., Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-Îą-synuclein is normalized by LRRK2 modulation., Neurobiol Dis. 2018 Aug;116:13-27.
Miklavc P, Ehinger K, Thompson KE, Hobi N, Shimshek DR, Frick M., Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis., PLoS One. 2014 Jan 21;9(1):e84926.
Other
Kelly, K., Chang, A., Hastings, L., Abdelmotilib, H. and West, A.B., Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain, Brain Research 1759 (2021): 147372.
Parkinson's disease
Taymans, J. M., Mutez, E., Sibran, W., Vandewynckel, L., Deldycke, C., Bleuse, S., Marchand, A., Sarchione, A., Leghay, C., Kreisler, A., Simonin, C., Koprich, J., Baille, G., Defebvre, L., Dujardin, K., Destée, A., & Chartier-Harlin, M. C., Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers, NPJ Parkinson's disease, 9(1), 21. https://doi.org/10.1038/s41531-023-00445-9
