Lewis inbred rats

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Adjuvant-induced arthritis

Fechtner S, Singh AK, Srivastava I, Szlenk CT, Muench TR, Natesan S, Ahmed S., Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1?-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor, Front Immunol. 2019 May 8;10:1027. doi: 10.3389/fimmu.2019.01027. eCollection 2019.

Katri A, D?browska A, Löfvall H, Ding M, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K., Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model, Arthritis Res Ther. 2019 Feb 22;21(1):68. doi: 10.1186/s13075-019-1819-9.

Yu R, Song D, DuBois DC, Almon RR, Jusko WJ., Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats, AAPS J. 2019 Jul 24;21(5):93. doi: 10.1208/s12248-019-0362-6.

Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG., Modulation of Lymphocyte Potassium Channel K(V)1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin, ACS Pharmacol Transl Sci. 2020 May 14;3(4):720-736. doi: 10.1021/acsptsci.0c00035. eCollection 2020 Aug 14.

Meka RR, Venkatesha SH, Acharya B, Moudgil KD., Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy, Nanomedicine (Lond). 2019 Jun;14(11):1455-1469. doi: 10.2217/nnm-2018-0501. Epub 2019 Apr 2.

Haque M, Singh AK, Ouseph MM, Ahmed S., Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant-Induced Arthritis, Arthritis Rheumatol. 2021 Jun;73(6):943-954. doi: 10.1002/art.41611. Epub 2021 Apr 20.

Halpert G, Halperin Sheinfeld M, Monteran L, Sharif K, Volkov A, Nadler R, Schlesinger A, Barshak I, Kalechman Y, Blank M, Shoenfeld Y, Amital H., The tellurium-based immunomodulator, AS101 ameliorates adjuvant-induced arthritis in rats, Clin Exp Immunol. 2021 Mar;203(3):375-384. doi: 10.1111/cei.13553. Epub 2020 Dec 8.

Experimental allergic encephalomyelitis

Boyles DA, Schwarz MM, Albe JR, McMillen CM, O'Malley KJ, Reed DS, Hartman AL., Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate, J Gen Virol. 2021 Feb;102(2):001522. doi: 10.1099/jgv.0.001522.

Perianes-Cachero A, Lobo MVT, Hernández-Pinto AM, Busto R, Lasunción-Ripa MA, Arilla-Ferreiro E, Puebla-Jiménez L., Oxidative Stress and Lymphocyte Alterations in Chronic Relapsing Experimental Allergic Encephalomyelitis in the Rat Hippocampus and Protective Effects of an Ethanolamine Phosphate Salt, Mol Neurobiol. 2020 Feb;57(2):860-878. doi: 10.1007/s12035-019-01774-8. Epub 2019 Sep 10.

Pouzol L, Piali L, Bernard CC, Martinic MM, Steiner B, Clozel M., Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis, Innov Clin Neurosci. 2019 Mar 1;16(3-4):22-30.

General studies

Bingham JR, Kniery KR, Jorstad NL, Horkayne-Szakaly I, Hoffer ZS, Salgar SK., "Stem cell therapy to promote limb function recovery in peripheral nerve damage in a rat model" - Experimental research, Ann Med Surg (Lond). 2019 Mar 28;41:20-28. doi: 10.1016/j.amsu.2019.03.009. eCollection 2019 May.

Petrik M, Umlaufova E, Raclavsky V, Palyzova A, Havlicek V, Pfister J, Mair C, Novy Z, Popper M, Hajduch M, Decristoforo C., (68)Ga-labelled desferrioxamine-B for bacterial infection imaging, Eur J Nucl Med Mol Imaging. 2021 Feb;48(2):372-382. doi: 10.1007/s00259-020-04948-y. Epub 2020 Jul 30.

Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM., A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure, Sci Transl Med. 2020 Mar 4;12(533):eaay1041. doi: 10.1126/scitranslmed.aay1041.

Acosta FM, Stojkova K, Brey EM, Rathbone CR., A Straightforward Approach to Engineer Vascularized Adipose Tissue Using Microvascular Fragments, Tissue Eng Part A. 2020 Aug;26(15-16):905-914. doi: 10.1089/ten.TEA.2019.0345. Epub 2020 Apr 6.

Hoff U, Bubalo G, Fechner M, Blum M, Zhu Y, Pohlmann A, Hentschel J, Arakelyan K, Seeliger E, Flemming B, Gürgen D, Rothe M, Niendorf T, Manthati VL, Falck JR, Haase M, Schunck WH, Dragun D., A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury, Acta Physiol (Oxf). 2019 Oct;227(2):e13297. doi: 10.1111/apha.13297. Epub 2019 Jun 2.

Bucher ML, Barrett CW, Moon CJ, Mortimer AD, Burton EA, Greenamyre JT, Hastings TG., Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson's disease, NPJ Parkinsons Dis. 2020 Nov 13;6(1):34. doi: 10.1038/s41531-020-00134-x.

Acosta FM, Howland KK, Stojkova K, Hernandez E, Brey EM, Rathbone CR., Adipogenic Differentiation Alters Properties of Vascularized Tissue-Engineered Skeletal Muscle, Tissue Eng Part A. 2021 Aug 25. doi: 10.1089/ten.TEA.2021.0064. Online ahead of print.

Mathot F, Rbia N, Bishop AT, Hovius SER, Shin AY., Adipose derived mesenchymal stem cells seeded onto a decellularized nerve allograft enhances angiogenesis in a rat sciatic nerve defect model, Microsurgery. 2020 Jul;40(5):585-592. doi: 10.1002/micr.30579. Epub 2020 Mar 31.

Klooster A, Larkin JR, Wiersema-Buist J, Gans RO, Thornalley PJ, Navis G, van Goor H, Leuvenink HG, Bakker SJ., Are brain and heart tissue prone to the development of thiamine deficiency?, Alcohol. 2013 May;47(3):215-21. doi: 10.1016/j.alcohol.2012.12.014. Epub 2013 Jan 26.

Callahan PM, Plagenhoef MR, Blake DT, Terry AV Jr., Atomoxetine improves memory and other components of executive function in young-adult rats and aged rhesus monkeys, Neuropharmacology. 2019 Sep 1;155:65-75. doi: 10.1016/j.neuropharm.2019.05.016. Epub 2019 May 18.

Ebrahimi AG, Hollister-Lock J, Sullivan BA, Tsuchida R, Bonner-Weir S, Weir GC., Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability, Mol Metab. 2020 May;35:100959. doi: 10.1016/j.molmet.2020.02.002. Epub 2020 Feb 14.

Eichendorff, S., Svendsen, P., Bender, D., Keiding, S., Christensen, E. I., Deleuran, B., & Moestrup, S. K. (2015)., Biodistribution and PET imaging of a novel [68Ga]-anti-CD163-antibody conjugate in rats with collagen-induced arthritis and in controls., Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging, 17(1), 87-93. doi:10.1007/s11307-014-0768-6 [doi]

Steiner R, Dhar M, Stephenson SM, Newby S, Bow A, Pedersen A, Anderson DE., Biometric Data Comparison Between Lewis and Sprague Dawley Rats, Front Vet Sci. 2019 Dec 20;6:469. doi: 10.3389/fvets.2019.00469. eCollection 2019.

Juříková T, Luptáková D, Kofroňová O, Škríba A, Novák J, Marešová H, Palyzová A, Petřík M, Havlíček V, Benada O., Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs, J Fungi (Basel). 2020 Oct 30;6(4):257. doi: 10.3390/jof6040257.

Nanjundaiah, S. M., Venkatesha, S. H., Yu, H., Tong, L., Stains, J. P., & Moudgil, K. D. (2012)., Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk., The Journal of Biological Chemistry, 287(26), 22216-22226. doi:10.1074/jbc.M112.356816 [doi]

Yu, H., Venkatesha, S. H., Nanjundaiah, S., Tong, L., & Moudgil, K. D. (2012)., Celastrus treatment modulates antigen-induced gene expression in lymphoid cells of arthritic rats., International Journal of Immunopathology and Pharmacology, 25(2), 455-466. doi:15 [pii]

van der Feen DE, Bossers GPL, Hagdorn QAJ, Moonen JR, Kurakula K, Szulcek R, Chappell J, Vallania F, Donato M, Kok K, Kohli JS, Petersen AH, van Leusden T, Demaria M, Goumans MTH, De Boer RA, Khatri P, Rabinovitch M, Berger RMF, Bartelds B., Cellular senescence impairs the reversibility of pulmonary arterial hypertension, Sci Transl Med. 2020 Jul 29;12(554):eaaw4974. doi: 10.1126/scitranslmed.aaw4974.

Roura-Martínez D, Ucha M, Orihuel J, Ballesteros-Yáńez I, Castillo CA, Marcos A, Ambrosio E, Higuera-Matas A., Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking, Addict Biol. 2020 Mar;25(2):e12706. doi: 10.1111/adb.12706. Epub 2019 Jan 8.

Oliva F, Maffulli N, Gissi C, Veronesi F, Calciano L, Fini M, Brogini S, Gallorini M, Antonetti Lamorgese Passeri C, Bernardini R, Cicconi R, Mattei M, Berardi AC., Combined ascorbic acid and T(3) produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study, J Orthop Surg Res. 2019 Feb 18;14(1):54. doi: 10.1186/s13018-019-1098-9.

Simonyan, K., Feng, X., Henriquez, V. M., & Ludlow, C. L. (2012)., Combined laryngeal inflammation and trauma mediate long-lasting immunoreactivity response in the brainstem sensory nuclei in the rat., Frontiers in Integrative Neuroscience, 6, 97. doi:10.3389/fnint.2012.00097 [doi]

Roura-Martínez D, Díaz-Bejarano P, Ucha M, Paiva RR, Ambrosio E, Higuera-Matas A., Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration, Neuropharmacology. 2020 Dec 1;180:108290. doi: 10.1016/j.neuropharm.2020.108290. Epub 2020 Sep 1.

Yu, H., Lu, C., Tan, M. T., & Moudgil, K. D. (2013)., Comparative antigen-induced gene expression profiles unveil novel aspects of susceptibility/resistance to adjuvant arthritis in rats., Molecular Immunology, 56(4), 531-539. doi:10.1016/j.molimm.2013.05.230 [doi]

Messer JG, La S, Kipp DE, Castillo EJ, Yarrow JF, Jorgensen M, Wnek RD, Kimmel DB, Aguirre JI., Diet-induced Generalized Periodontitis in Lewis Rats, Comp Med. 2019 Oct 1;69(5):384-400. doi: 10.30802/AALAS-CM-18-000113. Epub 2019 Oct 1.

Schweizer R, Schnider JT, Fanzio PM, Tsuji W, Kostereva N, Solari MG, Plock JA, Gorantla VS., Effect of Systemic Adipose-derived Stem Cell Therapy on Functional Nerve Regeneration in a Rodent Model, Plast Reconstr Surg Glob Open. 2020 Jul 21;8(7):e2953. doi: 10.1097/GOX.0000000000002953. eCollection 2020 Jul.

Schmid, H. A., & Brueggen, J. (2012)., Effects of somatostatin analogs on glucose homeostasis in rats., The Journal of Endocrinology, 212(1), 49-60. doi:10.1530/JOE-11-0224 [doi]

Lamb RJ, Schindler CW, Ginsburg BC., Ethanol-paired stimuli can increase reinforced ethanol responding, Alcohol. 2020 Jun;85:27-34. doi: 10.1016/j.alcohol.2019.10.007. Epub 2019 Nov 2.

Rostami S, Xu M, Datta S, Haykal S., Evaluation of Early Markers of Ischemia-reperfusion Injury and Preservation Solutions in a Modified Hindlimb Model of Vascularized Composite Allotransplantation., Transplant Direct. 2021 Dec 13;8(1):e1251. doi: 10.1097/TXD.0000000000001251. eCollection 2022 Jan.

Gissi C, Radeghieri A, Antonetti Lamorgese Passeri C, Gallorini M, Calciano L, Oliva F, Veronesi F, Zendrini A, Cataldi A, Bergese P, Maffulli N, Berardi AC., Extracellular vesicles from rat-bone-marrow mesenchymal stromal/stem cells improve tendon repair in rat Achilles tendon injury model in dose-dependent manner: A pilot study, PLoS One. 2020 Mar 12;15(3):e0229914. doi: 10.1371/journal.pone.0229914. eCollection 2020.

Sandalon, S., Konnecke, B., Levkovitch-Verbin, H., Simons, M., Hein, K., Sattler, M. B., . . . Ofri, R. (2013)., Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension., Experimental Eye Research, 115, 47-56. doi:10.1016/j.exer.2013.06.018 [doi]

Mathot F, Saffari TM, Rbia N, Nijhuis THJ, Bishop AT, Hovius SER, Shin AY., Functional Outcomes of Nerve Allografts Seeded with Undifferentiated and Differentiated Mesenchymal Stem Cells in a Rat Sciatic Nerve Defect Model, Plast Reconstr Surg. 2021 Aug 1;148(2):354-365. doi: 10.1097/PRS.0000000000008191.

Hellenbrand DJ, Haldeman CL, Lee JS, Gableman AG, Dai EK, Ortmann SD, Gotchy JC, Miller KK, Doucas AM, Nowak NC, Murphy WL, Hanna AS., Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles, Neural Regen Res. 2021 May;16(5):871-877. doi: 10.4103/1673-5374.297786.

Vieira WF, Malange KF, de Magalhăes SF, Dos Santos GG, de Oliveira ALR, da Cruz-Höfling MA, Parada CA., Gait analysis correlates mechanical hyperalgesia in a model of streptozotocin-induced diabetic neuropathy: A CatWalk dynamic motor function study, Neurosci Lett. 2020 Sep 25;736:135253. doi: 10.1016/j.neulet.2020.135253. Epub 2020 Jul 22.

Rbia N, Bulstra LF, Friedrich PF, Bishop AT, Nijhuis THJ, Shin AY., Gene expression and growth factor analysis in early nerve regeneration following segmental nerve defect reconstruction with a mesenchymal stromal cell-enhanced decellularized nerve allograft, Plast Reconstr Surg Glob Open. 2020 Jan 21;8(1):e2579. doi: 10.1097/GOX.0000000000002579. eCollection 2020 Jan.

Maretti-Mira AC, Wang X, Wang L, DeLeve LD., Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat, Hepatology. 2019 Mar;69(3):1259-1272. doi: 10.1002/hep.30227. Epub 2019 Feb 7.

Matta B, Bora PS, Neuhouser AJ, Bora NS., Inhibitory role of transforming growth factor ?2 in experimental autoimmune anterior uveitis, Graefes Arch Clin Exp Ophthalmol. 2019 May;257(5):953-960. doi: 10.1007/s00417-019-04255-9. Epub 2019 Feb 5.

Kusner LL, Yucius K, Sengupta M, Sprague AG, Desai D, Nguyen T, Charisse K, Kuchimanchi S, Kallanthottathil R, Fitzgerald K, Kaminski HJ, Borodovsky A., Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis, Mol Ther Methods Clin Dev. 2019 May 10;13:484-492. doi: 10.1016/j.omtm.2019.04.009. eCollection 2019 Jun 14.

Elrashidy RA, Liu G., Long-term diabetes causes molecular alterations related to fibrosis and apoptosis in rat urinary bladder, Exp Mol Pathol. 2019 Dec;111:104304. doi: 10.1016/j.yexmp.2019.104304. Epub 2019 Aug 31.

Saffari S, Saffari TM, Chan K, Borschel GH, Shin AY., Mesenchymal stem cells and local tacrolimus delivery synergistically enhance neurite extension, Biotechnol Bioeng. 2021 Nov;118(11):4477-4487. doi: 10.1002/bit.27916. Epub 2021 Aug 25.

Yu, H., Venkatesha, S. H., & Moudgil, K. D. (2012)., Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of celastrus-derived celastrol., International Immunopharmacology, 13(4), 499-506. doi:10.1016/j.intimp.2012.05.015 [doi]

Saffari TM, Mathot F, Thaler R, van Wijnen AJ, Bishop AT, Shin AY., Microcomputed analysis of nerve angioarchitecture after combined stem cell delivery and surgical angiogenesis to nerve allograft, J Plast Reconstr Aesthet Surg. 2021 Aug;74(8):1919-1930. doi: 10.1016/j.bjps.2020.12.039. Epub 2020 Dec 24.

Ängeby Möller K, Klein S, Seeliger F, Finn A, Stenfors C, Svensson CI., Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats, Neurobiol Pain. 2019 Sep 3;6:100036. doi: 10.1016/j.ynpai.2019.100036. eCollection 2019 Aug-Dec.

Men H, Hankins MA, Bock AS, Beaton BP, Davis DJ, Chesney KL, Bryda EC., Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes, Mamm Genome. 2021 Jun;32(3):173-182. doi: 10.1007/s00335-021-09868-2. Epub 2021 Apr 11.

Yosef B, Zhou Y, Mouschouris K, Poteracki J, Soker S, Criswell T., N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury, Mil Med. 2020 Jan 7;185(Suppl 1):25-34. doi: 10.1093/milmed/usz232.

Saffari TM, Mathot F, Bishop AT, Shin AY., New methods for objective angiogenesis evaluation of rat nerves using microcomputed tomography scanning and conventional photography, Microsurgery. 2020 Mar;40(3):370-376. doi: 10.1002/micr.30537. Epub 2019 Nov 23.

Azagra-Boronat I, Massot-Cladera M, Knipping K, Van't Land B, Tims S, Stahl B, Knol J, Garssen J, Franch Ŕ, Castell M, Pérez-Cano FJ, Rodríguez-Lagunas MJ., Oligosaccharides Modulate Rotavirus-Associated Dysbiosis and TLR Gene Expression in Neonatal Rats, Cells. 2019 Aug 11;8(8):876. doi: 10.3390/cells8080876.

Forouzan S, Nieto SJ, Kosten TA., Persistence of Operant Responding for Food After Prior Cocaine Exposure in Fischer 344 But Not Lewis Rats, Am J Addict. 2021 Jul;30(4):358-365. doi: 10.1111/ajad.13152. Epub 2021 Apr 2.

Subramani R, Estrada A, Dixon M, Parada M, Rodriguez S, Pedroza DA, Ramirez MD, Clift A, Garcia L, Lakshmanaswamy R., Pregnancy Inhibits Mammary Carcinogenesis by Persistently Altering the Hypothalamic-Pituitary Axis, Cancers (Basel). 2021 Jun 26;13(13):3207. doi: 10.3390/cancers13133207.

Tong, L., Nanjundaiah, S. M., Venkatesha, S. H., Astry, B., Yu, H., & Moudgil, K. D. (2014)., Pristimerin, a naturally occurring triterpenoid, protects against autoimmune arthritis by modulating the cellular and soluble immune mediators of inflammation and tissue damage., Clinical Immunology (Orlando, Fla.), 155(2), 220-230. doi:10.1016/j.clim.2014.09.014 [doi]

De Miranda BR, Rocha EM, Castro SL, Greenamyre JT., Protection from ?-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20, NPJ Parkinsons Dis. 2020 Dec 8;6(1):38. doi: 10.1038/s41531-020-00139-6.

Fumagalli G, Monfrini M, Donzelli E, Rodriguez-Menendez V, Bonandrini B, Figliuzzi M, Remuzzi A, D'Amico G, Cavaletti G, Scuteri A., Protective Effect of Human Mesenchymal Stem Cells on the Survival of Pancreatic Islets, Int J Stem Cells. 2020 Mar 30;13(1):116-126. doi: 10.15283/ijsc19094.

Vieira WF, de Magalhães SF, Farias FH, de Thomaz AA, Parada CA., Raman spectroscopy of dorsal root ganglia from streptozotocin-induced diabetic neuropathic rats submitted to photobiomodulation therapy, J Biophotonics. 2019 Nov;12(11):e201900135. doi: 10.1002/jbio.201900135. Epub 2019 Jul 2.

Saffari TM, Mathot F, Friedrich PF, Bishop AT, Shin AY., Revascularization patterns of nerve allografts in a rat sciatic nerve defect model, J Plast Reconstr Aesthet Surg. 2020 Mar;73(3):460-468. doi: 10.1016/j.bjps.2019.11.048. Epub 2019 Dec 11.

De Miranda BR, Fazzari M, Rocha EM, Castro S, Greenamyre JT., Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence, Toxicol Sci. 2019 Jul 1;170(1):133-143. doi: 10.1093/toxsci/kfz082.

Weiss JB, Phillips CJ, Malin EW, Gorantla VS, Harding JW, Salgar SK., Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies, Ann Med Surg (Lond). 2021 Oct 8;71:102917. doi: 10.1016/j.amsu.2021.102917. eCollection 2021 Nov.

Hestehave S, Abelson KS, Brřnnum Pedersen T, Munro G., Stress sensitivity and cutaneous sensory thresholds before and after neuropathic injury in various inbred and outbred rat strains, Behav Brain Res. 2019 Dec 16;375:112149. doi: 10.1016/j.bbr.2019.112149. Epub 2019 Aug 13.

Shrestha BM, Haylor J., Surgical Anatomy and Microvascular Surgical Technique Relevant to Experimental Renal Transplant in Rat Employing Aortic and Inferior Venacaval Conduits, Exp Clin Transplant. 2019 Feb;17(1):18-25. doi: 10.6002/ect.2017.0061. Epub 2017 Nov 15.

Damle, S. R., Krzyzanowska, A., Frawley, R. J., & Cunningham, M. E. (2013)., Surgical anatomy, transperitoneal approach, and early postoperative complications of a ventral lumbar spine surgical model in lewis rats., Comparative Medicine, 63(5), 409-415.

Saffari TM, Badreldin A, Mathot F, Bagheri L, Bishop AT, van Wijnen AJ, Shin AY., Surgical angiogenesis modifies the cellular environment of nerve allografts in a rat sciatic nerve defect model, Gene. 2020 Aug 15;751:144711. doi: 10.1016/j.gene.2020.144711. Epub 2020 Apr 27.

Saffari TM, Mathot F, Friedrich PF, Bishop AT, Shin AY., Surgical Angiogenesis of Decellularized Nerve Allografts Improves Early Functional Recovery in a Rat Sciatic Nerve Defect Model, Plast Reconstr Surg. 2021 Sep 1;148(3):561-570. doi: 10.1097/PRS.0000000000008291.

Wang X, Walkey CJ, Maretti-Mira AC, Wang L, Johnson DL, DeLeve LD., Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition, Hepatology. 2020 Nov;72(5):1771-1785. doi: 10.1002/hep.31179. Epub 2020 Oct 22.

Kothari A, Rajagopalan P., The assembly of integrated rat intestinal-hepatocyte cultures, Bioeng Transl Med. 2019 Nov 9;5(1):e10146. doi: 10.1002/btm2.10146. eCollection 2020 Jan.

Hanwright PJ, Rath JB, von Guionneau N, Slavin B, Pinni S, Zlotolow D, Shores J, Dellon AL, Tuffaha SH., The Effects of a Porcine Extracellular Matrix Nerve Wrap as an Adjunct to Primary Epineurial Repair, J Hand Surg Am. 2021 Sep;46(9):813.e1-813.e8. doi: 10.1016/j.jhsa.2020.11.023. Epub 2021 Feb 6.

Vida, V. L., Dedja, A., Faggin, E., Speggiorin, S., Padalino, M. A., Boccuzzo, G., . . . Stellin, G. (2012)., The effects of basic fibroblast growth factor in an animal model of acute mechanically induced right ventricular hypertrophy., Cardiology in the Young, 22(4), 436-442. doi:10.1017/S1047951111002034 [doi]

De Miranda BR, Castro SL, Rocha EM, Bodle CR, Johnson KE, Greenamyre JT., The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease, Neurobiol Dis. 2021 Jun;153:105312. doi: 10.1016/j.nbd.2021.105312. Epub 2021 Feb 23.

Buck SA, Steinkellner T, Aslanoglou D, Villeneuve M, Bhatte SH, Childers VC, Rubin SA, De Miranda BR, O'Leary EI, Neureiter EG, Fogle KJ, Palladino MJ, Logan RW, Glausier JR, Fish KN, Lewis DA, Greenamyre JT, McCabe BD, Cheetham CEJ, Hnasko TS, Freyberg Z., Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration, Aging Cell. 2021 May;20(5):e13365. doi: 10.1111/acel.13365. Epub 2021 Apr 28.

Immunology

Santak, M., Markusic, M., Balija, M. L., Kopac, S. K., Jug, R., Orvell, C., . . . Forcic, D. (2015)., Accumulation of defective interfering viral particles in only a few passages in vero cells attenuates mumps virus neurovirulence., Microbes and Infection / Institut Pasteur, 17(3), 228-236. doi:10.1016/j.micinf.2014.11.006 [doi]

Reese SR, Wilson NA, Huang Y, Ptak L, Degner KR, Xiang D, Redfield RR, Zhong W, Panzer SE., B-cell Deficiency Attenuates Transplant Glomerulopathy in a Rat Model of Chronic Active Antibody-mediated Rejection, Transplantation. 2021 Jul 1;105(7):1516-1529. doi: 10.1097/TP.0000000000003530.

Shavit-Stein E, Aronovich R, Sylantiev C, Gera O, Gofrit SG, Chapman J, Dori A., Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis, Front Neurol. 2019 Jan 4;9:1139. doi: 10.3389/fneur.2018.01139. eCollection 2018.

Wang H, Li S, Dai Q, Gonzalez A, Tran ON, Sun H, DeFronzo RA, Dean DD, Yeh CK, Chen XD., Culture on a native bone marrow-derived extracellular matrix restores the pancreatic islet basement membrane, preserves islet function, and attenuates islet immunogenicity, FASEB J. 2020 Jun;34(6):8044-8056. doi: 10.1096/fj.201902893R. Epub 2020 Apr 19.

Zhang P, Tu GH, Wei J, Santiago P, Larrabee LR, Liao-Chan S, Mistry T, Chu ML, Sai T, Lindquist K, Long H, Chaparro-Riggers J, Salek-Ardakani S, Yeung YA., Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity, Cell Rep. 2019 Jun 11;27(11):3117-3123.e5. doi: 10.1016/j.celrep.2019.05.027.

Dobiáš R, Škríba A, Pluháček T, Petřík M, Palyzová A, Káňová M, Čubová E, Houšť J, Novák J, Stevens DA, Mitulovič G, Krejčí E, Hubáček P, Havlíček V., Noninvasive Combined Diagnosis and Monitoring of Aspergillus and Pseudomonas Infections: Proof of Concept, J Fungi (Basel). 2021 Sep 6;7(9):730. doi: 10.3390/jof7090730.

Rigo-Adrover MDM, Knipping K, Garssen J, Saldańa-Ruíz S, Franch Ŕ, Castell M, Pérez-Cano FJ., Rotavirus Double Infection Model to Study Preventive Dietary Interventions, Nutrients. 2019 Jan 10;11(1):131. doi: 10.3390/nu11010131.

Morales-Ferré C, Azagra-Boronat I, Massot-Cladera M, Franch Ŕ, Castell M, Rodríguez-Lagunas MJ, Pérez-Cano FJ., Sexual Dimorphism Has Low Impact on the Response against Rotavirus Infection in Suckling Rats, Vaccines (Basel). 2020 Jun 29;8(3):345. doi: 10.3390/vaccines8030345.

Pepple KL, Wilson L, Van Gelder RN, Kovaleva M, Ubah OC, Steven J, Barelle CJ, Porter A., Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand, Transl Vis Sci Technol. 2019 Sep 18;8(5):11. doi: 10.1167/tvst.8.5.11. eCollection 2019 Sep.

Jiang G, Yun J, Kaplan HJ, Zhao Y, Sun D, Shao H., Vaccination with circulating exosomes in autoimmune uveitis prevents recurrent intraocular inflammation, Clin Exp Ophthalmol. 2021 Dec;49(9):1069-1077. doi: 10.1111/ceo.13990. Epub 2021 Sep 8.

Plume JM, Todd D, Bonthius DJ., Viral Strain Determines Disease Symptoms, Pathology, and Immune Response in Neonatal Rats with Lymphocytic Choriomeningitis Virus Infection, Viruses. 2019 Jun 14;11(6):552. doi: 10.3390/v11060552.

Oncology

Puntel, M., Muhammad, A. K., Candolfi, M., Salem, A., Yagiz, K., Farrokhi, C., . . . Castro, M. G. (2010)., A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics., Journal of Virology, 84(12), 6007-6017. doi:10.1128/JVI.00398-10 [doi]

King, G. D., Muhammad, A. K., Larocque, D., Kelson, K. R., Xiong, W., Liu, C., . . . Lowenstein, P. R. (2011)., Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen., Molecular Therapy : The Journal of the American Society of Gene Therapy, 19(10), 1793-1801. doi:10.1038/mt.2011.77 [doi]

King, G. D., Muhammad, A. K., Curtin, J. F., Barcia, C., Puntel, M., Liu, C., . . . Castro, M. G. (2008)., Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model., Neuro-Oncology, 10(1), 19-31. doi:15228517-2007-045 [pii]

King, G. D., Kroeger, K. M., Bresee, C. J., Candolfi, M., Liu, C., Manalo, C. M., . . . Castro, M. G. (2008)., Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits., Molecular Therapy : The Journal of the American Society of Gene Therapy, 16(4), 682-690. doi:10.1038/mt.2008.18 [doi]

Baker, G. J., Yadav, V. N., Motsch, S., Koschmann, C., Calinescu, A. A., Mineharu, Y., . . . Lowenstein, P. R. (2014), Mechanisms of glioma formation: Iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy., Neoplasia (New York, N.Y.), 16(7), 543-561. doi:10.1016/j.neo.2014.06.003 [doi]

Pool, S. E., ten Hagen, T. L., Koelewijn, S., de Jong, M., & Koning, G. A. (2012)., Multimodality imaging of somatostatin receptor-positive tumors with nuclear and bioluminescence imaging., Molecular Imaging, 11(1), 27-32.

Baker, G. J., Chockley, P., Yadav, V. N., Doherty, R., Ritt, M., Sivaramakrishnan, S., . . . Lowenstein, P. R. (2014)., Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity., Cancer Research, 74(18), 5079-5090. doi:10.1158/0008-5472.CAN-14-1203 [doi]

Bison, S. M., Pool, S. E., Koelewijn, S. J., van der Graaf, L. M., Groen, H. C., Melis, M., & de Jong, M. (2014)., Peptide receptor radionuclide therapy (PRRT) with [(177)lu-DOTA(0),tyr(3)]octreotate in combination with RAD001 treatment: Further investigations on tumor metastasis and response in the rat pancreatic CA20948 tumor model., EJNMMI Research, 4, 21-014-0021-y. eCollection 2014. doi:10.1186/s13550-014-0021-y [doi]

Jacobs, V. L., Landry, R. P., Liu, Y., Romero-Sandoval, E. A., & De Leo, J. A. (2012)., Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia., Neuro-Oncology, 14(2), 119-131. doi:10.1093/neuonc/nor194 [doi]

Poli, A., Wang, J., Domingues, O., Planaguma, J., Yan, T., Rygh, C. B., . . . Chekenya, M. (2013)., Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival., Oncotarget, 4(9), 1527-1546. doi:1291 [pii]

Preclinical (PK/PD)

Lu YJ, Wheeler LW 2nd, Chu H, Kleindl PJ, Pugh M, You F, Rao S, Garcia G, Wu HY, da Cunha AP, Johnson R, Westrick E, Cross V, Lloyd A, Dircksen C, Klein PJ, Vlahov IR, Low PS, Leamon CP., Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes., Cell Rep Med. 2021 Oct 19;2(10):100422. doi: 10.1016/j.xcrm.2021.100422. eCollection 2021 Oct 19.

Surgical

Transplantation

Hladíková Z, Voglová B, Pátíková A, Berková Z, Kříž J, Vojtíšková A, Leontovyč I, Jirák D, Saudek F., Bioluminescence Imaging In Vivo Confirms the Viability of Pancreatic Islets Transplanted into the Greater Omentum, Mol Imaging Biol. 2021 Oct;23(5):639-649. doi: 10.1007/s11307-021-01588-y. Epub 2021 Feb 18.

Tane S, Noda K, Toyoda Y, Shigemura N., Bronchial-arterial-circulation-sparing Lung Preservation: A New Organ Protection Approach for Lung Transplantation, Transplantation. 2020 Mar;104(3):490-499. doi: 10.1097/TP.0000000000002984.

Fidder SAJ, Furtmüller GJ, Simons B, Oh BC, Chicco M, Etra JW, Brayton C, Cooney CM, Vasilic D, Kern B, Lough D, Lee WPA, Redett RJ, Brandacher G, Cooney DS., Characterization of Clinical and Histological Rejection of Male Genital Tissues Using a Novel Microsurgical Rat Penile Transplantation Model, Transplantation. 2019 Nov;103(11):2245-2254. doi: 10.1097/TP.0000000000002812.

Shrestha BM, Haylor J., Complications and Their Prevention in Experimental Renal Transplantation in Rats, Exp Clin Transplant. 2019 Apr;17(2):202-209. doi: 10.6002/ect.2017.0072. Epub 2018 Dec 18.

Haam S, Noda K, Philips BJ, Harano T, Sanchez PG, Shigemura N., Cyclosporin A Administration During Ex Vivo Lung Perfusion Preserves Lung Grafts in Rat Transplant Model, Transplantation. 2020 Sep;104(9):e252-e259. doi: 10.1097/TP.0000000000003237.

Bath NM, Ding X, Wilson NA, Verhoven BM, Boldt BA, Sukhwal A, Reese SR, Panzer SE, Djamali A, Redfield RR 3rd., Desensitization and treatment with APRIL/BLyS blockade in rodent kidney transplant model, PLoS One. 2019 Feb 8;14(2):e0211865. doi: 10.1371/journal.pone.0211865. eCollection 2019.

Khalid U, Jenkins RH, Andrews R, Pino-Chavez G, Cossins BC, Chavez R, Bowen T, Fraser DJ., Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules, Sci Rep. 2021 May 10;11(1):9862. doi: 10.1038/s41598-021-89195-3.

Westerkamp, A. C., Mahboub, P., Meyer, S. L., Hottenrot, M., Ottens, P. J., Wiersema-Buist, J., . . . Porte, R. J. (2015)., End-ischemic machine perfusion reduces bile duct injury in donation after circulatory death rat donor livers., Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, doi:10.1002/lt.24200 [doi]

Liang JP, Accolla RP, Soundirarajan M, Emerson A, Coronel MM, Stabler CL., Engineering a macroporous oxygen-generating scaffold for enhancing islet cell transplantation within an extrahepatic site, Acta Biomater. 2021 Aug;130:268-280. doi: 10.1016/j.actbio.2021.05.028. Epub 2021 Jun 1.

Rbia N, Bulstra LF, Thaler R, Hovius SER, van Wijnen AJ, Shin AY., In Vivo Survival of Mesenchymal Stromal Cell-Enhanced Decellularized Nerve Grafts for Segmental Peripheral Nerve Reconstruction, J Hand Surg Am. 2019 Jun;44(6):514.e1-514.e11. doi: 10.1016/j.jhsa.2018.07.010. Epub 2018 Oct 6.

Juang, J. H., Hsu, B. R., Kuo, C. H., & Yaot, N. K. (2001)., Influence of donor age on mouse islet characteristics and transplantation., Cell Transplantation, 10(3), 277-284.

Wang X, Maretti-Mira AC, Wang L, DeLeve LD., Liver-Selective MMP-9 Inhibition in the Rat Eliminates Ischemia-Reperfusion Injury and Accelerates Liver Regeneration, Hepatology. 2019 Jan;69(1):314-328. doi: 10.1002/hep.30169. Epub 2018 Dec 20.

Westerkamp AC, Fujiyoshi M, Ottens PJ, Nijsten MWN, Touw DJ, de Meijer VE, Lisman T, Leuvenink HGD, Moshage H, Berendsen TA, Porte RJ., Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation, Transplantation. 2020 Sep;104(9):e271-e280. doi: 10.1097/TP.0000000000003216.

Zhao H, Chen Q, Huang H, Suen KC, Alam A, Cui J, Ciechanowicz S, Ning J, Lu K, Takata M, Gu J, Ma D., Osteopontin mediates necroptosis in lung injury after transplantation of ischaemic renal allografts in rats, Br J Anaesth. 2019 Oct;123(4):519-530. doi: 10.1016/j.bja.2019.05.041. Epub 2019 Jun 28.

van Rijt, W. G., Nieuwenhuijs-Moeke, G. J., van Goor, H., Ottens, P. J., Ploeg, R. J., & Leuvenink, H. G. (2013)., Renoprotective capacities of non-erythropoietic EPO derivative, ARA290, following renal ischemia/reperfusion injury., Journal of Translational Medicine, 11, 286-5876-11-286. doi:10.1186/1479-5876-11-286 [doi]

Goesch TR, Wilson NA, Zeng W, Verhoven BM, Zhong W, Coumbe Gitter MM, Fahl WE., Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats, Biomolecules. 2021 Jul 19;11(7):1054. doi: 10.3390/biom11071054.

Ramanathan, R., Pettinato, G., Beeston, J. T., Lee, D. D., Wen, X., Mangino, M. J., & Fisher, R. A. (2015)., Transplantation of human stem cell-derived hepatocytes in an animal model of acute liver failure., Surgery, 158(2), 349-359. doi:10.1016/j.surg.2015.04.014 [doi]