Fmr1 knockout rats
Related publications
Autism
Barnett BR, Casey CP, Torres-Velázquez M, Rowley PA, Yu JJ., Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study, Magn Reson Imaging. 2020 Jul;70:36-42. doi: 10.1016/j.mri.2020.04.002. Epub 2020 Apr 13.
Schiavi S, Carbone E, Melancia F, Buzzelli V, Manduca A, Campolongo P, Pallottini V, Trezza V., Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats, Nutr Neurosci. 2020 Sep 11:1-14. doi: 10.1080/1028415X.2020.1819107. Online ahead of print.
Fragile x syndrome
Auerbach, B., Manohar, S., Radziwon, K., & Salvi, R., Auditory hypersensitivity and processing deficits in a rat model of fragile X syndrome, Neurobiology of disease (2021): 105541.
Fernandes, G., Mishra, P. K., Nawaz, M. S., Donlin-Asp, P. G., Rahman, M. M., Hazra, A., ... & Chattarji, S., Correction of amygdalar dysfunction in a rat model of fragile X syndrome, Cell Reports 37, no. 2 (2021): 109805.
Kozono N, Okamura A, Honda S, Matsumoto M, Mihara T., Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome, Sci Rep. 2020 Nov 2;10(1):18799. doi: 10.1038/s41598-020-75893-x.
Hooper, A. W., Wong, H., Niibori, Y., Abdoli, R., Karumuthil-Melethil, S., Qiao, C., ... & Hampson, D. R., Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity, Molecular Therapy-Methods & Clinical Development 22 (2021): 196-209.
Subrahmanyam, R., Dwivedi, D., Rashid, Z., Bonnycastle, K., Cousin, M. A., & Chattarji, S., Reciprocal regulation of spontaneous synaptic vesicle fusion by Fragile X mental retardation protein and group I metabotropic glutamate receptors, Journal of Neurochemistry, 158, 1094 1109. 2021.
Golden CEM, Yee Y, Wang VX, Harony-Nicolas H, Hof PR, Lerch JP, Buxbaum JD., Reduced axonal caliber and structural changes in a rat model of Fragile X syndrome with a deletion of a K-Homology domain of Fmr1, Transl Psychiatry. 2020 Aug 12;10(1):280. doi: 10.1038/s41398-020-00943-x.
Wong H, Hooper AWM, Niibori Y, Lee SJ, Hategan LA, Zhang L, Karumuthil-Melethil S, Till SM, Kind PC, Danos O, Bruder JT, Hampson DR., Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome, Neurobiol Dis. 2020 Dec;146:105118. doi: 10.1016/j.nbd.2020.105118. Epub 2020 Oct 6.
Neuroscience
Yamazaki M, Arai T, Yarimizu J, Matsumoto M., 5-HT5A Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1-Targeted Transgenic Male Rat Model of Fragile X Syndrome., Int J Neuropsychopharmacol. 2022 Sep 28;25(9):786-793. doi: 10.1093/ijnp/pyac041.
Ruby, K; Falvey, K; Kulesza, R J;, Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats., Neuroscience Vol.303, 2015
Schiavi S, Manduca A, Carbone E, Buzzelli V, Rava A, Feo A, Ascone F, Morena M, Campolongo P, Hill MN, Trezza V, Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats, Neuropsychopharmacology. 2023 May;48(6):897-907. doi: 10.1038/s41386-022-01454-7
Parente M, Tonini C, Buzzelli V, Carbone E, Trezza V, Pallottini V., Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome., Int J Mol Sci. 2022 Mar 21;23(6). pii: 3408. doi: 10.3390/ijms23063408.
Till, Sally M; Asiminas, Antonis; Jackson, Adam D; Katsanevaki, Danai; Barnes, Stephanie A; Osterweil, Emily K; Bear, Mark F; Chattarji, Sumantra; Wood, Emma R; Wyllie, David J A; Kind, Peter C;, Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS., Human molecular genetics Vol.24, 2015
Rowley, Paul A; Guerrero-Gonzalez, Jose; Alexander, Andrew L; Yu, John-Paul J;, Convergent microstructural brain changes across genetic models of autism spectrum disorder-A pilot study., Psychiatry research. Neuroimaging Vol.283, 2019
Engineer, Crystal T; Centanni, Tracy M; Im, Kwok W; Rahebi, Kimiya C; Buell, Elizabeth P; Kilgard, Michael P;, Degraded speech sound processing in a rat model of fragile X syndrome., Brain research Vol.1564, 2014
Golden, Carla E M; Breen, Michael S; Koro, Lacin; Sonar, Sankalp; Niblo, Kristi; Browne, Andrew; Burlant, Natalie; Di Marino, Daniele; De Rubeis, Silvia; Baxter, Mark G; Buxbaum, Joseph D; Harony-Nicolas, Hala;, Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats., Cerebral cortex (New York, N.Y. : 1991) Vol.29, 2019
Berzhanskaya, Julia; Phillips, Marnie A; Gorin, Alexis; Lai, Chongxi; Shen, Jing; Colonnese, Matthew T;, Disrupted Cortical State Regulation in a Rat Model of Fragile X Syndrome., Cerebral cortex (New York, N.Y. : 1991) Vol.27, 2017
Saxena, K; Webster, J; Hallas-Potts, A; Mackenzie, R; Spooner, P A; Thomson, D; Kind, P; Chattarji, S; Morris, R G M;, Experiential contributions to social dominance in a rat model of fragile-X syndrome., Proceedings. Biological sciences Vol.285, 2018
Hamilton, Shannon M; Green, Jennie R; Veeraragavan, Surabi; Yuva, Lisa; McCoy, Aaron; Wu, Yumei; Warren, Joe; Little, Lara; Ji, Diana; Cui, Xiaoxia; Weinstein, Edward; Paylor, Richard;, Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders., Behavioral neuroscience Vol.128, 2014
D'Elia A, Schiavi S, Manduca A, Rava A, Buzzelli V, Ascone F, Orsini T, Putti S, Soluri A, Galli F, Soluri A, Mattei M, Cicconi R, Massari R, Trezza V., FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability., Cells 2023, 12(3), 347; https://doi.org/10.3390/cells12030347
Kenkel, W M; Yee, J R; Moore, K; Madularu, D; Kulkarni, P; Gamber, K; Nedelman, M; Ferris, C F;, Functional magnetic resonance imaging in awake transgenic fragile X rats: evidence of dysregulation in reward processing in the mesolimbic/habenular neural circuit., Translational psychiatry Vol.6, 2016
Maurin, Thomas; Melancia, Francesca; Jarjat, Marielle; Castro, Liliana; Costa, Lara; Delhaye, SĂŠbastien; Khayachi, Anouar; Castagnola, Sara; Mota, Elia; Di Giorgio, Audrey; Servadio, Michela; Drozd, Malgorzata; Poupon, GwĂŠnola; Schiavi, Sara; Sardone, Lara; Azoulay, StĂŠphane; Ciranna, Lucia; Martin, StĂŠphane; Vincent, Pierre; Trezza, Viviana; Bardoni, Barbara;, Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome., Cerebral cortex (New York, N.Y. : 1991) Vol.29, 2019
Schiavi S, Carbone E, Melancia F, et al., Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder, Front Behav Neurosci. 2022;16:951268.
Buzzelli V, Carbone E, Manduca A, Schiavi S, Feo A, Perederiy JV, Ambert KH, Hausman M, Trezza V., Psilocybin mitigates the cognitive deficits observed in a rat model of Fragile X syndrome., Genes (Basel). 2022 Oct 31;13(11). pii: 1995. doi: 10.3390/genes13111995.
Berzhanskaya, Julia; Phillips, Marnie A; Shen, Jing; Colonnese, Matthew T;, Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome., Scientific reports Vol.6, 2016
Asiminas, Antonis; Jackson, Adam D; Louros, Susana R; Till, Sally M; Spano, Teresa; Dando, Owen; Bear, Mark F; Chattarji, Sumantra; Hardingham, Giles E; Osterweil, Emily K; Wyllie, David J A; Wood, Emma R; Kind, Peter C;, Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome., Science translational medicine Vol.11, 2019
