Cynomolgus Macaque

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Cell Therapy

Gorsuch CL, Nemec P, Yu M, Xu S, Han D, Smith J, Lape J, van Buuren N, Ramirez R, Muench RC, Holdorf MM, Feierbach B, Falls G, Holt J, Shoop W, Sevigny E, Karriker F, Brown RV, Joshi A, Goodwin T, Tam YK, Lin PJC, Semple SC, Leatherbury N, Delaney Iv WE, Jantz D, Rhoden Smith A., Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo, Mol Ther. 2022 Sep 7;30(9):2909-2922. doi: 10.1016/j.ymthe.2022.05.013.

Cellular therapies

Nowak-Imialek M, Wunderlich S, Herrmann D, Breitschuh-Leibling S, Gohring G, Petersen B, Klein S, Baulain U, Lucas-Hahn A, Martin U, Niemann H., In Vitro and In Vivo Interspecies Chimera Assay Using Early Pig Embryos, Cell Reprogram. 2020 Jun;22(3):118-133. doi: 10.1089/cell.2019.0107. Epub 2020 May 19.

COVID-19

Baisa G, Rancour D, Mansfield K, Burns M, Martin L, Cunha D, Fischer J, Muecksch F, Hatziioannou T, Bieniasz P, Schomburg F, Luke K., A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques, bioRxiv. 2020 Dec 21:2020.12.20.422693. doi: 10.1101/2020.12.20.422693. Preprint.

Harris, Paul E.; Brasel, Trevor; Massey, Christopher; Herst, C. V.; Burkholz, Scott; Lloyd, Peter; Blankenberg, Tikoes; Bey, Thomas M.; Carback, Richard; Hodge, Thomas; Ciotlos, Serban; Wang, Lu; Comer, Jason E.; Rubsamen, Reid M., A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques, Vaccines. 2021.

Liu, Y., Garron, T. M., Chang, Q., Su, Z., Zhou, C., Qiu, Y., ... & Gong, B., Cell-Type Apoptosis in Lung during SARS-CoV-2 Infection, Pathogens 10, no. 5 (2021): 509.

Finch CL, Crozier I, Lee JH, Byrum R, Cooper TK, Liang J, Sharer K, Solomon J, Sayre PJ, Kocher G, Bartos C, Aiosa NM, Castro M, Larson PA, Adams R, Beitzel B, Di Paola N, Kugelman JR, Kurtz JR, Burdette T, Nason MC, Feuerstein IM, Palacios G, St Claire MC, Lackemeyer MG, Johnson RF, Braun KM, Ramuta MD, Wada J, Schmaljohn CS, Friedrich TC, O'Connor DH, Kuhn JH., Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis), bioRxiv. 2020 May 14:2020.05.14.096727. doi: 10.1101/2020.05.14.096727. Preprint.

Gorman, Matthew J.; Patel, Nita; Guebre-Xabier, Mimi; Zhu, Alex L.; Atyeo, Caroline; Pullen, Krista M.; Loos, Carolin; Goez-Gazi, Yenny; Carrion, Ricardo; Tian, Jing-Hui; Yuan, Dansu; Bowman, Kathryn A.; Zhou, Bin; Maciejewski, Sonia; McGrath, Marisa E.; Logue, James; Frieman, Matthew B.; Montefiori, David; Mann, Colin; Schendel, Sharon; Amanat, Fatima; Krammer, Florian; Saphire, Erica Ollmann; Lauffenburger, Douglas A.; Greene, Ann M.; Portnoff, Alyse D.; Massare, Michael J.; Ellingsworth, Larry; Glenn, Gregory; Smith, Gale; Alter, Galit, Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination, Cell Reports Medicine. 2021.

Aweda TA, Cheng SH, Lenhard SC, Sepp A, Skedzielewski T, Hsu CY, Marshall S, Haag H, Kehler J, Jagdale P, Peter A, Schmid MA, Gehman A, Doan M, Mayer AP, Gorycki P, Fanget M, Colas C, Smith B, Maier CC, Alsaid H., In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys., Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):667-678. doi: 10.1007/s00259-022-06012-3. Epub 2022 Oct 28.

Boras, B., Jones, R. M., Anson, B. J., Arenson, D., Aschenbrenner, L., Bakowski, M. A., ... & Allerton, C., Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19, Nature Communications 12, no. 1 (2021): 1-17.

Diabetes

Vahle, John L; Byrd, Richard A; Blackbourne, Jamie L; Martin, Jennifer A; Sorden, Steven D; Ryan, Thomas; Pienkowski, Thomas; Rosol, Thomas J; Snyder, Paul W; KlĂśppel, GĂźnter;, Effects of the GLP-1 Receptor Agonist Dulaglutide on the Structure of the Exocrine Pancreas of Cynomolgus Monkeys., Toxicologic pathology Vol.43, 2015

Levy, Odile E; Jodka, Carolyn M; Ren, Shijun Steven; Mamedova, Lala; Sharma, Abhinandini; Samant, Manoj; DSouza, Lawrence J; Soares, Christopher J; Yuskin, Diane R; Jin, Li Jenny; Parkes, David G; Tatarkiewicz, Krystyna; Ghosh, Soumitra S, Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of action., PloS one Vol.9, 2014

Myer, James R; Romach, Elizabeth H; Elangbam, Chandikumar S;, Species- and dose-specific pancreatic responses and progression in single- and repeat-dose studies with GI181771X: a novel cholecystokinin 1 receptor agonist in mice, rats, and monkeys, Toxicologic pathology Vol.42, 2014

Kolumam, Ganesh; Chen, Mark Z; Tong, Raymond; Zavala-Solorio, Jose; Kates, Lance; van Bruggen, Nicholas; Ross, Jed; Wyatt, Shelby K; Gandham, Vineela D; Carano, Richard A D; Dunshee, Diana Ronai; Wu, Ai-Luen; Haley, Benjamin; Anderson, Keith; Warming, SĂ¸ren; Rairdan, Xin Y; Lewin-Koh, Nicholas; Zhang, Yingnan; Gutierrez, Johnny; Baruch, Amos; Gelzleichter, Thomas R; Stevens, Dale; Rajan, Sharmila; Bainbridge, Travis W; Vernes, Jean-Michel; Meng, Y Gloria; Ziai, James; Soriano, Robert H; Brauer, Matthew J; Chen, Yongmei; Stawicki, Scott; Kim, Hok Seon; Comps-Agrar, LaĂŤtitia; Luis, Elizabeth; Spiess, Christoph; Wu, Yan; Ernst, James A; McGuinness, Owen P; Peterson, Andrew S; Sonoda, Junichiro;, Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/?Klotho Complex, EBioMedicine Vol.2, 2015

General studies

Le, Kha N; Gibiansky, Leonid; Good, Jeremy; Davancaze, Teresa; van Lookeren Campagne, Menno; Loyet, Kelly M; Morimoto, Alyssa; Jin, Jin; Damico-Beyer, Lisa A; Hanley, William D;, A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy., The Journal of pharmacology and experimental therapeutics Vol.355, 2015

Calderon B, Reynolds NA, Swearingen CA, Carter QL, Bivi N, Cramer JW, Alexander CL, Siegel RW, Konrad RJ., A Monovalent Fab Affinity-Capture and Elution Bridging Immunoassay Overcomes Rheumatoid Factor Interference while Accurately Detecting Antidrug Antibodies, J Appl Lab Med. 2023 Sep 7;8(5):896-908. doi: 10.1093/jalm/jfad035.

Datta-Mannan, Amita; Croy, Johnny E; Schirtzinger, Linda; Torgerson, Stacy; Breyer, Matthew; Wroblewski, Victor J;, Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys, mAbs Vol.8, 2016

Heyen, Jonathan R; Rojko, Jennifer; Evans, Mark; Brown, Tom P; Bobrowski, Walter F; Vitsky, Allison; Dalton, Shana; Tripathi, Niraj; Bollini, Sangeetha Subbarao; Johnson, Theodore; Lin, John C; Khan, Nasir; Han, Bora;, Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis)., Toxicologic pathology Vol.42, 2014

Cirimotich, Chris M; Vela, Eric M; Garver, Jennifer; Barnewall, Roy E; Miller, Brian D; Meister, Gabriel T; Rogers, James V;, Chikungunya virus infection in Cynomolgus macaques following Intradermal and aerosol exposure., Virology journal Vol.14, 2017

Grant-Klein, Rebecca J; Altamura, Louis A; Badger, Catherine V; Bounds, Callie E; Van Deusen, Nicole M; Kwilas, Steven A; Vu, Hong A; Warfield, Kelly L; Hooper, Jay W; Hannaman, Drew; Dupuy, Lesley C; Schmaljohn, Connie S;, Codon-optimized filovirus DNA vaccines delivered by intramuscular electroporation protect cynomolgus macaques from lethal Ebola and Marburg virus challenges., Human vaccines & immunotherapeutics Vol.11, 2015

Bantseev, Vladimir; Miller, Paul E; Nork, T Michael; Rasmussen, Carol A; McKenzie, Aija; Christian, Brian J; Booler, Helen; Thackaberry, Evan A;, Determination of a No Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Cynomolgus Monkeys., Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.35, 2019

Phuah, Jiayao; Wong, Eileen A; Gideon, Hannah P; Maiello, Pauline; Coleman, M Teresa; Hendricks, Matthew R; Ruden, Rachel; Cirrincione, Lauren R; Chan, John; Lin, Philana Ling; Flynn, JoAnne L;, Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques., Infection and immunity Vol.84, 2016

Malkevich, Nina V; Hopkins, Robert J; Bernton, Edward; Meister, Gabriel T; Vela, Eric M; Atiee, George; Johnson, Virginia; Nabors, Gary S; Aimes, Ronald T; Ionin, Boris; Skiadopoulos, Mario H;, Efficacy and safety of AVP-21D9, an anthrax monoclonal antibody, in animal models and humans., . Antimicrobial agents and chemotherapy Vol.58, 2014

Dunshee, Diana Ronai; Bainbridge, Travis W; Kljavin, Noelyn M; Zavala-Solorio, Jose; Schroeder, Amy C; Chan, Ruby; Corpuz, Racquel; Wong, Manda; Zhou, Wei; Deshmukh, Gauri; Ly, Justin; Sutherlin, Daniel P; Ernst, James A; Sonoda, Junichiro;, Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21., The Journal of biological chemistry Vol.291, 2016

Husar, Elisabeth; Solonets, Maria; Kuhlmann, Olaf; Schick, Eginhard; Piper-Lepoutre, Hanna; Singer, Thomas; Tyagi, Gaurav;, Hypersensitivity Reactions to Obinutuzumab in Cynomolgus Monkeys and Relevance to Humans., Toxicologic pathology Vol.45, 2017

Greig JA, Martins KM, Breton C, Lamontagne RJ, Zhu Y, He Z, White J, Zhu JX, Chichester JA, Zheng Q, Zhang Z, Bell P, Wang L, Wilson JM., Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration, Nat Biotechnol. 2023 Nov 6. doi: 10.1038/s41587-023-01974-7. Online ahead of print.

Hutt, Julie A; Lovchik, Julie A; Drysdale, Melissa; Sherwood, Robert L; Brasel, Trevor; Lipscomb, Mary F; Lyons, C Rick;, Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge., The American journal of pathology Vol.184, 2014

Quinet, Elaine M; Basso, Michael D; Halpern, Anita R; Yates, David W; Steffan, Robert J; Clerin, Valerie; Resmini, Christine; Keith, James C; Berrodin, Thomas J; Feingold, Irene; Zhong, Wenyan; Hartman, Helen B; Evans, Mark J; Gardell, Stephen J; DiBlasio-Smith, Elizabeth; Mounts, William M; LaVallie, Edward R; Wrobel, Jay; Nambi, Ponnal; Vlasuk, George P, LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse., Journal of lipid research Vol.50, 2009

Alfson, Kendra J; Avena, Laura E; Beadles, Michael W; Staples, Hilary; Nunneley, Jerritt W; Ticer, Anysha; Dick, Edward J; Owston, Michael A; Reed, Christopher; Patterson, Jean L; Carrion, Ricardo; Griffiths, Anthony;, Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques, Journal of virology Vol.89, 2015

Mitchell, Andrea Z; McMahon, Carrie; Beck, Tom W; Sarazan, R Dustan, Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs, Journal of pharmacological and toxicological methods Vol.62,

Buse, Eberhard; Häeger, Jan-Dirk; Svensson-Arvelund, Judit; Markert, Udo R; Faas, Marijke M; Ernerudh, Jan; Dixon, Darlene; Cline, J Mark; Pfarrer, Christiane;, The placenta in toxicology. Part I: Animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis)., Toxicologic pathology Vol.42, 2014

Hoffmann, Peter; Bentley, Phil; Sahota, Pritam; Schoenfeld, Heidi; Martin, Lori; Longo, Linda; Spaet, Robert; Moulin, Pierre; Pantano, Serafino; Dubost, Valerie; Lapadula, Dan; Burkey, Bryan; Kaushik, Virendar; Zhou, Wei; Hayes, Michael; Flavahan, Nick; Chibout, Salah-Dine; Busch, Steve;, Vascular origin of vildagliptin-induced skin effects in Cynomolgus monkeys: pathomechanistic role of peripheral sympathetic system and neuropeptide Y, Toxicologic pathology Vol.42, 2014

Immunology

Hunegnaw R, Honko AN, Wang L, Carr D, Murray T, Shi W, Nguyen L, Storm N, Dulan CNM, Foulds KE, Agans KN, Cross RW, Geisbert JB, Cheng C, Ploquin A, Stanley DA, Geisbert TW, Nabel GJ, Sullivan NJ., A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates, Sci Transl Med. 2022 Dec 14;14(675):eabq6364. doi: 10.1126/scitranslmed.abq6364.

De Pooter, Dorien; Van Gulck, Ellen; Chen, Antony; Evans, Claire F.; Neefs, Jean-Marc; Horton, Helen; Boden, Daniel, A Therapeutic Hepatitis B Virus DNA Vaccine Induces Specific Immune Responses in Mice and Non-Human Primates, Vaccines. 2021.

Vitale LA, He LZ, Thomas LJ, Wasiuk A, O'Neill T, Widger J, Crocker A, Mills-Chen L, Forsberg E, Weidlick J, Patterson C, Hammond RA, Boyer J, Sisson C, Alvarado D, Goldstein J, Marsh HC Jr, Keler T., Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy, Cancer Immunol Immunother. 2020 Oct;69(10):2125-2137. doi: 10.1007/s00262-020-02610-y. Epub 2020 May 25.

Marcus, Hadar; Thompson, Emily; Zhou, Yan; Bailey, Michael; Donaldson, Mitzi M.; Stanley, Daphne A.; Asiedu, Clement; Foulds, Kathryn E.; Roederer, Mario; Moliva, Juan I.; Sullivan, Nancy J., Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates, Frontiers in Immunology. 2021.

Shearer, Jeffry D.; Henning, Lisa; Sanford, Daniel C.; Li, Na; Skiadopoulos, Mario H.; Reece, Joshua J.; Ionin, Boris; Savransky, Vladimir, Efficacy of the AV7909 anthrax vaccine candidate in guinea pigs and nonhuman primates following two immunizations two weeks apart, Vaccine. 2021.

Sivko, G S; Stark, G V; Tordoff, K P; Taylor, K L; Glaze, E; VanRaden, M; Schiffer, J M; Hewitt, J A; Quinn, C P; Nuzum, E O;, Evaluation of early immune response-survival relationship in cynomolgus macaques after Anthrax Vaccine Adsorbed vaccination and Bacillus anthracis spore challenge, Vaccine Vol.34, 2016

Latuszek A, Liu Y, Olsen O, Foster R, Cao M, Lovric I, Yuan M, Liu N, Chen H, Zhang Q, Xiao H, Springer C, Ehrlich G, Kamat V, Rafique A, Hu Y, Krueger P, Huang T, Poueymirou W, Babb R, Rosconi MP, Retter MW, Chen G, Morton L, Zambrowicz B, Cao J, Romano C, Olson WC., Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5, PLoS One. 2020 May 8;15(5):e0231892. doi: 10.1371/journal.pone.0231892. eCollection 2020.

Gideon, Hannah P; Phuah, Jiayao; Junecko, Beth A; Mattila, Joshua T;, Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques., Mucosal immunology Vol.12, 2019

Dheilly, Elie; Moine, Valéry; Broyer, Lucile; Salgado-Pires, Susana; Johnson, Zoë; Papaioannou, Anne; Cons, Laura; Calloud, Sébastien; Majocchi, Stefano; Nelson, Robert; Rousseau, François; Ferlin, Walter; Kosco-Vilbois, Marie; Fischer, Nicolas; Masternak, Krzysztof;, Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies., Molecular therapy : the journal of the American Society of Gene Therapy Vol.25, 2017

Khan S, Salisch NC, Gil AI, Boedhoe S, Boer KF, Serroyen J, Schuitemaker H, Zahn RC., Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets, NPJ Vaccines. 2022 Nov 15;7(1):146. doi: 10.1038/s41541-022-00567-w.

Finch CL, King TH, Alfson KJ, Albanese KA, Smith JNP, Smock P, Jakubik J, Goez-Gazi Y, Gazi M, Dutton JW 3rd, Clemmons EA, Mattix ME, Carrion R Jr, Rudge T Jr, Ridenour A, Woodin SF, Hunegnaw R, Sullivan NJ, Xu R., Single-Shot ChAd3-MARV Vaccine in Modified Formulation Buffer Shows 100% Protection of NHPs, accines (Basel). 2022 Nov 15;10(11):1935. doi: 10.3390/vaccines10111935.

Infectious disease

Woolsey C, Borisevich V, Agans KN, O'Toole R, Fenton KA, Harrison MB, Prasad AN, Deer DJ, Gerardi C, Morrison N, Cross RW, Eldridge JH, Matassov D, Geisbert TW., A Highly Attenuated Panfilovirus VesiculoVax Vaccine Rapidly Protects Nonhuman Primates Against Marburg Virus and 3 Species of Ebola Virus, J Infect Dis. 2023 Nov 15;228(Supplement_7):S660-S670. doi: 10.1093/infdis/jiad157.

Boyer AE, Gallegos-Candela M, Lins RC, Solano MI, Woolfitt AR, Lee JS, Sanford DC, Knostman KAB, Quinn CP, Hoffmaster AR, Pirkle JL, Barr JR., Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model, PLoS Pathog. 2022 Dec 19;18(12):e1010735. doi: 10.1371/journal.ppat.1010735. eCollection 2022 Dec.

Slay RM, Hewitt JA, Crumrine M., Determination of the Postexposure Prophylactic Benefit of Oral Azithromycin and Clarithromycin Against Inhalation Anthrax in Cynomolgus Macaques, Clin Infect Dis. 2022 Oct 17;75(Suppl 3):S411-S416. doi: 10.1093/cid/ciac569.

Alfson KJ, Goez-Gazi Y, Gazi M, Chou YL, Niemuth NA, Mattix ME, Staples HM, Klaffke B, Rodriguez GF, Bartley C, Ticer A, Clemmons EA, Dutton JW 3rd, Griffiths A, Meister GT, Sanford DC, Cirimotich CM, Carrion R Jr., Development of a Well-Characterized Cynomolgus Macaque Model of Marburg Virus Disease for Support of Vaccine and Therapy Development, Vaccines (Basel). 2022 Aug 14;10(8):1314. doi: 10.3390/vaccines10081314.

Alfson KJ, Goez-Gazi Y, Gazi M, Chou YL, Niemuth NA, Mattix ME, Staples H, Klaffke B, Rodriguez GF, Escareno P, Bartley C, Ticer A, Clemmons EA, Dutton Iii JW, Griffiths A, Meister GT, Sanford DC, Cirimotich CM, Carrion R Jr., Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development, Vaccines (Basel). 2022 Oct 15;10(10):1723. doi: 10.3390/vaccines10101723.

Williams JA, Long SY, Zeng X, Kuehl K, Babka AM, Davis NM, Liu J, Trefry JC, Daye S, Facemire PR, Iversen PL, Bavari S, Pitt ML, Nasar F., Eastern equine encephalitis virus rapidly infects and disseminates in the brain and spinal cord of cynomolgus macaques following aerosol challenge, PLoS Negl Trop Dis. 2022 May 9;16(5):e0010081. doi: 10.1371/journal.pntd.0010081. eCollection 2022 May.

Kammanadiminti, S., Comer, J., Meister, G., Carnelley, T., Toth, D., & Kodihalli, S., Efficacy of ANTHRASIL (Anthrax Immune Globulin Intravenous (Human)) in rabbit and nonhuman primate models of inhalational anthrax: Data supporting approval under animal rule, PLoS One. 2023 Mar 17;18(3):e0283164.

Triplett CA, Niemuth NA, Cirimotich C, Meister G, Guebre-Xabier M, Patel N, Massare M, Glenn G, Smith G, Alfson KJ, Goez-Gazi Y, Carrion R Jr., Immune Correlates of Protection from Filovirus Efficacy Studies in Non-Human Primates, Vaccines (Basel). 2022 Aug 18;10(8):1338. doi: 10.3390/vaccines10081338.

Abelson D, Barajas J, Stuart L, Kim D, Marimuthu A, Hu C, Yamamoto B, Ailor E, Whaley KJ, Vu H, Agans KN, Borisevich V, Deer DJ, Dobias NS, Woolsey C, Prasad AN, Peel JE, Lawrence WS, Cross RW, Geisbert TW, Fenton KA, Zeitlin L., Long-term Prophylaxis Against Aerosolized Marburg Virus in Nonhuman Primates With an Afucosylated Monoclonal Antibody, J Infect Dis. 2023 Nov 13;228(Supplement_7):S701-S711. doi: 10.1093/infdis/jiad278.

Comer JE, Brasel T, Massey S, Beasley DW, Cirimotich CM, Sanford DC, Chou YL, Niemuth NA, Novak J, Sabourin CL, Merchlinsky M, Long JP, Stavale EJ, Wolfe DN., Natural History of Marburg Virus Infection to Support Medical Countermeasure Development, Viruses. 2022 Oct 18;14(10):2291. doi: 10.3390/v14102291.

Neuroscience

Takemura H, Palomero-Gallagher N, Axer M, Gräßel D, Jorgensen MJ, Woods R, Zilles K., Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system, Elife. 2020 Aug 26;9:e55444. doi: 10.7554/eLife.55444.

Niu M, Impieri D, Rapan L, Funck T, Palomero-Gallagher N, Zilles K., Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus, Elife. 2020 Jul 2;9:e55979. doi: 10.7554/eLife.55979.

Obesity

Yang, Linda; Chang, Chih-Chuan; Sun, Zhe; Madsen, Dennis; Zhu, Haisun; Padkjær, Søren B; Wu, Xiaoai; Huang, Tao; Hultman, Karin; Paulsen, Sarah J; Wang, Jishu; Bugge, Anne; Frantzen, Jane Boesen; Nørgaard, Per; Jeppesen, Jacob Fuglsbjerg; Yang, Zhiru; Secher, Anna; Chen, Haibin; Li, Xun; John, Linu Mary; Shan, Bing; He, Zhenhua; Gao, Xiang; Su, Jing; Hansen, Kristian T; Yang, Wei; Jørgensen, Sebastian Beck;, GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand., Nature medicine Vol.23, 2017

Pharmacology

St Andre, Michael; Johnson, Mark; Bansal, Prashant N; Wellen, Jeremy; Robertson, Andrew; Opsahl, Alan; Burch, Peter M; Bialek, Peter; Morris, Carl;, A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys, Skeletal muscle Vol.7, 2017

Barfield RM, Kim YC, Chuprakov S, Zhang F, Bauzon M, Ogunkoya AO, Yeo D, Hickle C, Pegram MD, Rabuka D, Drake PM., A Novel HER2-targeted Antibody-drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels, Mol Cancer Ther. 2020 Sep;19(9):1866-1874. doi: 10.1158/1535-7163.MCT-20-0190. Epub 2020 Jul 10.

Smith, Eric J; Olson, Kara; Haber, Lauric J; Varghese, Bindu; Duramad, Paurene; Tustian, Andrew D; Oyejide, Adelekan; Kirshner, Jessica R; Canova, Lauren; Menon, Jayanthi; Principio, Jennifer; MacDonald, Douglas; Kantrowitz, Joel; Papadopoulos, Nicholas; Stahl, Neil; Yancopoulos, George D; Thurston, Gavin; Davis, Samuel;, A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys., Scientific reports Vol.5, 2015

Elliott AG, Huang JX, Neve S, Zuegg J, Edwards IA, Cain AK, Boinett CJ, Barquist L, Lundberg CV, Steen J, Butler MS, Mobli M, Porter KM, Blaskovich MAT, Lociuro S, Strandh M, Cooper MA., An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria, Nat Commun. 2020 Jun 23;11(1):3184. doi: 10.1038/s41467-020-16950-x.

Sainson RCA, Thotakura AK, Kosmac M, Borhis G, Parveen N, Kimber R, Carvalho J, Henderson SJ, Pryke KL, Okell T, O'Leary S, Ball S, Van Krinks C, Gamand L, Taggart E, Pring EJ, Ali H, Craig H, Wong VWY, Liang Q, Rowlands RJ, Lecointre M, Campbell J, Kirby I, Melvin D, Germaschewski V, Oelmann E, Quaratino S, McCourt M., An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression, Cancer Immunol Res. 2020 Dec;8(12):1568-1582. doi: 10.1158/2326-6066.CIR-20-0034. Epub 2020 Sep 30.

Nagy CF, Mondick J, Serbina N, Casey LS, Carpenter SE, French J, Guttendorf R., Animal-to-Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal Rule., Clin Transl Sci. 2017 Jan;10(1):12-19.

Carter QL, Siegel RW, Qian Y, Konrad RJ., Application of a novel drug-tolerant target assay for measuring target engagement when only one epitope remains after therapeutic antibodies bind their targets, J Immunol Methods. 2021 Feb;489:112916. doi: 10.1016/j.jim.2020.112916. Epub 2020 Nov 23.

Thran M, Pönisch M, Danz H, Horscroft N, Ichtchenko K, Tzipori S, Shoemaker CB., Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies, Sci Rep. 2023 Sep 5;13(1):14632. doi: 10.1038/s41598-023-41092-7.

Lin, Cheng-Wen; Sherman, Bryan; Moore, Lori A; Laethem, Carmen L; Lu, Da-Wen; Pattabiraman, Padmanabhan P; Rao, Ponugoti Vasantha; deLong, Mitchell A; Kopczynski, Casey C;, Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma., Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.34,

Benichou O, Coskun T, Gonciarz MD, Garhyan P, Adams AC, Du Y, Dunbar JD, Martin JA, Mather KJ, Pickard RT, Reynolds VL, Robins DA, Zvada SP, Emmerson PJ., Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist, Cell Metab. 2023 Feb 7;35(2):274-286.e10. doi: 10.1016/j.cmet.2022.12.011. Epub 2023 Jan 10.

Shen J, Moats RA, Pollack HA, Robinson MR, Attar M., Distribution of (14)C-Latanoprost Following a Single Intracameral Administration Versus Repeated Topical Administration, Ophthalmol Ther. 2020 Dec;9(4):929-940. doi: 10.1007/s40123-020-00285-3. Epub 2020 Aug 1.

Vahle, John L; Byrd, Richard A; Blackbourne, Jamie L; Martin, Jennifer A; Sorden, Steven D; Ryan, Thomas; Pienkowski, Thomas; Wijsman, John A; Smith, Holly W; Rosol, Thomas J;, Effects of Dulaglutide on Thyroid C Cells and Serum Calcitonin in Male Monkeys, Endocrinology Vol.156, 2015

Russo, Andrew T; Grosenbach, Douglas W; Brasel, Trevor L; Baker, Robert O; Cawthon, Andrew G; Reynolds, Erin; Bailey, Tara; Kuehl, Philip J; Sugita, Victoria; Agans, Krystle; Hruby, Dennis E;, Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques., The Journal of infectious diseases Vol.218, 2018

Shearer JD, Henning L, Sanford DC, Li N, Skiadopoulos MH, Reece JJ, Ionin B, Savransky V., Efficacy of the AV7909 anthrax vaccine candidate in guinea pigs and nonhuman primates following two immunizations two weeks apart, Vaccine. 2021 Jan 3;39(1):1-5. doi: 10.1016/j.vaccine.2020.10.095. Epub 2020 Nov 13.

Yamamoto BJ, Shadiack AM, Carpenter S, Sanford D, Henning LN, O'Connor E, Gonzales N, Mondick J, French J, Stark GV, Fisher AC, Casey LS, Serbina NV., Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease Severity. Antimicrob Agents Chemother., 2016 Sep 23;60(10):5787-95.

Frederick A, Sullivan J, Liu L, Adamowicz M, Lukason M, Raymer J, Luo Z, Jin X, Rao KN, O'Riordan C., Engineered Capsids for Efficient Gene Delivery to the Retina and Cornea, Hum Gene Ther. 2020 Jul;31(13-14):756-774. doi: 10.1089/hum.2020.070.

Chui, R. W., Baublits, J., Chandra, F. A., Jones, Z. W., Engwall, M. J., & Vargas, H. M., Evaluation of moxifloxacin in canine and non?human primate telemetry assays: Comparison of QTc interval prolongation by timepoint and concentration?QTc analysis, Clinical and translational science 14.6 (2021): 2379-2390.

Almholt K, Wang J, Pass J, Røder G, Padkjær SB, Hebsgaard JB, Xia W, Yang L, Forsell J, Breinholt VM, Thygesen P, Agersø¸ H, Loftager M, Usher PA., Identification and preclinical development of an anti-proteolytic uPA antibody for rheumatoid arthritis, J Mol Med (Berl). 2020 Apr;98(4):585-593. doi: 10.1007/s00109-020-01889-9. Epub 2020 Feb 27.

Laffan SB, Thomson AS, Mai S, Fishman C, Kambara T, Nistala K, Raymond JT, Chen S, Ramani T, Pageon L, Polsky R, Watkins M, Ottolangui G, White JR, Maier C, Herdman M, Bouma G., Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates, PLoS One. 2020 Apr 23;15(4):e0231655. doi: 10.1371/journal.pone.0231655. eCollection 2020.

Damann N, Bahrenberg G, Stockhausen H, Habermann CJ, Lesch B, Frank-Foltyn R, Lee J, Ann J, Christoph T., In vitro characterization of the thermoneutral transient receptor potential vanilloid-1 (TRPV1) inhibitor GRTE16523, Eur J Pharmacol. 2020 Mar 15;871:172934. doi: 10.1016/j.ejphar.2020.172934. Epub 2020 Jan 16.

Lawrence SA, Blankenship R, Brown R, Estwick S, Ellis B, Thangaraju A, Datta-Mannan A., Influence of FcRn binding properties on the gastrointestinal absorption and exposure profile of Fc molecules, Bioorg Med Chem. 2020 Dec 21;32:115942. doi: 10.1016/j.bmc.2020.115942. Online ahead of print.

Datta-Mannan A, Estwick S, Zhou C, Choi H, Douglass NE, Witcher DR, Lu J, Beidler C, Millican R., Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies, MAbs. 2020 Jan 1;12(1):1770028. doi: 10.1080/19420862.2020.1770028.

Bennett G, Brown A, Mudd G, Huxley P, Van Rietschoten K, Pavan S, Chen L, Watcham S, Lahdenranta J, Keen N., MMAE Delivery Using the Bicycle Toxin Conjugate BT5528, Mol Cancer Ther. 2020 Jul;19(7):1385-1394. doi: 10.1158/1535-7163.MCT-19-1092. Epub 2020 May 12.

Del Balzo U, Signore PE, Walkinshaw G, Seeley TW, Brenner MC, Wang Q, Guo G, Arend MP, Flippin LA, Chow FA, Gervasi DC, Kjaergaard CH, Langsetmo I, Guenzler V, Liu DY, Klaus SJ, Lin A, Neff TB., Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease, J Pharmacol Exp Ther. 2020 Aug;374(2):342-353. doi: 10.1124/jpet.120.265181. Epub 2020 Jun 2.

Yamamoto BJ, Shadiack AM, Carpenter S, Sanford D, Henning LN, Gonzales N, O'Connor E, Casey LS, Serbina NV, Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational Anthrax., Antimicrob Agents Chemother. 2016 Sep 23;60(10):5796-805.

Xie, Hongsheng; Chung, Jou-Ku; Mascelli, Mary Ann; McCauley, Thomas G;, Pharmacokinetics and bioavailability of a therapeutic enzyme (idursulfase) in cynomolgus monkeys after intrathecal and intravenous administration., PloS one Vol.10, 2015

V Khetarpal, T Herbst, D Shefchek, S Ash, Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals, Xenobiotica 51, no. 10 (2021): 1155-1180.

Jennings D, Huntwork-Rodriguez S, Henry AG, Sasaki JC, Meisner R, Diaz D, Solanoy H, Wang X, Negrou E, Bondar VV, Ghosh R, Maloney MT, Propson NE, Zhu Y, Maciuca RD, Harris L, Kay A, LeWitt P, King TA, Kern D, Ellenbogen A, Goodman I, Siderowf A, Aldred J, Omidvar O, Masoud ST, Davis SS, Arguello A, Estrada AA, de Vicente J, Sweeney ZK, Astarita G, Borin MT, Wong BK, Wong H, Nguyen H, Scearce-Levie K, Ho C, Troyer MD., Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease, Sci Transl Med. 2022 Jun 8;14(648):eabj2658. doi: 10.1126/scitranslmed.abj2658. Epub 2022 Jun 8.

Ramot, Y., Rottenberg, Y., Domb, A. J., Kubek, M. J., Williams, K. D., & Nyska, A., Preclinical In-Vivo Safety of a Novel Thyrotropin-Releasing Hormone-Loaded Biodegradable Nanoparticles After Intranasal Administration in Rats and Primates., International journal of toxicology, 42(4), 334–344.

Tess DA, Eng H, Kalgutkar AS, Litchfield J, Edmonds DJ, Griffith DA, Varma MVS., Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs, J Med Chem. 2020 Oct 22;63(20):11831-11844. doi: 10.1021/acs.jmedchem.0c01033. Epub 2020 Oct 9.

Kistner A, Chichester JA, Wang L, Calcedo R, Greig JA, Cardwell LN, Wright MC, Couthouis J, Sethi S, McIntosh BE, McKeever K, Wadsworth S, Wilson JM, Kakkis E, Sullivan BA., Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques, Gene Ther. 2023 Oct 13. doi: 10.1038/s41434-023-00423-z. Online ahead of print.

Randolph JT, Voight EA, Greszler SN, Uno BE, Newton JN, Gleason KM, Stolarik D, Van Handel C, Bow DAJ, DeGoey DA., Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530), J Med Chem. 2020 Oct 8;63(19):11034-11044. doi: 10.1021/acs.jmedchem.0c00956. Epub 2020 Sep 17.

Mackman, R. L., Hui, H. C., Perron, M., Murakami, E., Palmiotti, C., Lee, G., ... & Cihlar, T., Prodrugs of a 1?-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV, Journal of Medicinal Chemistry 64, no. 8 (2021): 5001-5017.

Wei YL, Wegesser T, Kuhns S, Werner J, Lebrec H, Wang X., Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015), Immunotoxicol. 2022 Dec;19(1):109-116. doi: 10.1080/1547691X.2022.2113841.

Liu J, Xavy S, Mihardja S, Chen S, Sompalli K, Feng D, Choi T, Agoram B, Majeti R, Weissman IL, Volkmer JP., Targeting macrophage checkpoint inhibitor SIRPÎą for anticancer therapy, JCI Insight. 2020 Jun 18;5(12):e134728. doi: 10.1172/jci.insight.134728.

Baublits, Joel; Vargas, Hugo M.; Engwall, Michael J., The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies, Journal of Pharmacological and Toxicological Methods. 2021.

Trefry, John C.; Rossi, Franco D.; Accardi, Michael V.; Dorsey, Brandi L.; Sprague, Thomas R.; Wollen-Roberts, Suzanne E.; Shamblin, Joshua D.; Kimmel, Adrienne E.; Glass, Pamela J.; Miller, Lynn J.; Burke, Crystal W.; Cardile, Anthony P.; Smith, Darci R.; Bavari, Sina; Authier, Simon; Pratt, William D.; Pitt, Margaret L.; Nasar, Farooq, The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus, PLOS Neglected Tropical Diseases. 2021.

Kim J, Li C, Wang H, Kaviraj S, Singh S, Savergave L, Raghuwanshi A, Gil S, Germond A, Baldessari A, Chen B, Roffler S, Fender P, Drescher C, Carter D, Lieber A. , Translational development of a tumor junction opening technology., Sci Rep. 2022 May 11;12(1):7753. doi: 10.1038/s41598-022-11843-z.

Kovalova N, Boyles J, Wen Y, Witcher DR, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK., Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human, Biopharm Drug Dispos. 2020 Mar;41(3):111-125. doi: 10.1002/bdd.2222. Epub 2020 Mar 10.

Walgren, Jennie L; Carfagna, Mark A; Koger, Deanna; Sgro, Mario; Kallman, Mary Jeanne;, Withdrawal assessment following subchronic oral ketamine administration in Cynomolgus macaques., Drug development research Vol.75, 2014

Toxicology

Hordeaux J, Buza EL, Dyer C, Goode T, Mitchell TW, Richman L, Denton N, Hinderer C, Katz N, Schmid R, Miller R, Choudhury GR, Horiuchi M, Nambiar K, Yan H, Li M, Wilson JM., Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology, Hum Gene Ther. 2020 Aug;31(15-16):808-818. doi: 10.1089/hum.2020.167. Epub 2020 Jul 31.

Obert LA, Suttie A, Abdi M, Gales T, Dwyer D, Fritz W, Robertson N, Weir L, Frazier K., Congenital Unilateral Renal Aplasia in a Cynomolgus Monkey (Macaca fascicularis) With Investigation Into Potential Pathogenesis, Toxicol Pathol. 2020 Aug;48(6):766-783. doi: 10.1177/0192623320941834. Epub 2020 Aug 20.

Grossmann H, Weinbauer GF, Baker A, Fuchs A, Luetjens CM., Enhanced normograms and pregnancy outcome analysis in nonhuman primate developmental toxicity studies, Reprod Toxicol. 2020 Aug;95:29-36. doi: 10.1016/j.reprotox.2020.04.074. Epub 2020 May 13.

Luetjens CM, Fuchs A, Baker A, Weinbauer GF., Group size experiences with enhanced pre- and postnatal development studies in the long-tailed macaque (Macaca fascicularis), Primate Biol. 2020 Mar 11;7(1):1-4. doi: 10.5194/pb-7-1-2020. eCollection 2020.

Zinn, Kurt R; Korb, Melissa; Samuel, Sharon; Warram, Jason M; Dion, David; Killingsworth, Cheryl; Fan, Jinda; Schoeb, Trenton; Strong, Theresa V; Rosenthal, Eben L;, IND-directed safety and biodistribution study of intravenously injected cetuximab-IRDye800 in cynomolgus macaques., Molecular imaging and biology Vol.17, 2015

Laing ST, Bockenstedt MM, Booler HS., Inflammation of a Posterior Ciliary Artery in a Naive Cynomolgus Macaque, Toxicol Pathol. 2020 Aug 28:192623320952337. doi: 10.1177/0192623320952337. Online ahead of print.

Andaya R, Booler H, Nagata DA, Lawson C, Vogt J, Schuetz C, Chang DP, Bantseev V., Intravitreal Administration of Acetyl Triethyl Citrate and Benzyl Benzoate Is Retinotoxic in Rabbits but Not in Cynomolgus Monkeys, Toxicol Pathol. 2020 Nov 28:192623320971571. doi: 10.1177/0192623320971571. Online ahead of print.

Schultze, Albert Eric; Anderson, Jason M; Kern, Tom G; Justus, Ryan W; Lee, Hsiu-Yung Cindy; Zieske, Lynn R; Goodson, Robert James; Florey, Sara Hudson;, Longitudinal studies of cardiac troponin I concentrations in serum from male cynomolgus monkeys: resting values and effects of oral and intravenous dosing on biologic variability., Veterinary clinical pathology Vol.44, 2015

Baptista MAS, Merchant K, Barrett T, Bhargava S, Bryce DK, Ellis JM, Estrada AA, Fell MJ, Fiske BK, Fuji RN, Galatsis P, Henry AG, Hill S, Hirst W, Houle C, Kennedy ME, Liu X, Maddess ML, Markgraf C, Mei H, Meier WA, Needle E, Ploch S, Royer C, Rudolph K, Sharma AK, Stepan A, Steyn S, Trost C, Yin Z, Yu H, Wang X, Sherer TB., LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits, Sci Transl Med. 2020 Apr 22;12(540):eaav0820. doi: 10.1126/scitranslmed.aav0820.

Turk JR, Deaton AM, Yin J, Stolina M, Felx M, Boyd G, Bienvenu JG, Varela A, Guillot M, Holdsworth G, Wolfreys A, Dwyer D, Kumar SV, de Koning EM, Qu Y, Engwall M, Locher K, Ward LD, Glaus C, He YD, Boyce RW., Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture, Regul Toxicol Pharmacol. 2020 Aug;115:104697. doi: 10.1016/j.yrtph.2020.104697. Epub 2020 Jun 23.

Dere E, Crowell S, Maia M, Schuetz C, Lai P, Bantseev V, Booler H., Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy, Toxicol Pathol. 2020 Dec 10:192623320976095. doi: 10.1177/0192623320976095. Online ahead of print.

Huet F, Miller J, Miller PE, Hayden C, Glick JJ, Bentley A, De Benedetto C, McPherson LE, Turner OC., Observation of Silicone Oil Within the Vitreous and Sclera Following Intravitreal Administration of Biotherapeutics Using Insulin Syringes in Cynomolgus Monkeys, Toxicol Pathol. 2020 Dec 4:192623320966543. doi: 10.1177/0192623320966543. Online ahead of print.

Weber K, Häcker R, Hardisty JF, Harris SB, Hayes AW., Oral repeated-dose toxicity studies of BIA 10-2474 in cynomolgus monkeys, Regul Toxicol Pharmacol. 2020 Mar;111:104547. doi: 10.1016/j.yrtph.2019.104547. Epub 2019 Dec 6.

Haworth, Richard; Boyle, Molly; Edwards, Paul; Gupta, Reenu; Fagg, Rajni; Karantabias, George; Price, Mark, Preclinical Safety Assessment of 2 Inhaled Single-Domain Antibodies in the Cynomolgus Monkey, Toxicologic Pathology. 2021.

Korte S, Runge F, Wozniak MM, Ludwig FT, Smieja D, Korytko P, Mecklenburg L., Range of Neurological Signs in Cynomolgus Monkeys After Intrathecal Bolus Administration of Antisense Oligonucleotides, Int J Toxicol. 2020 Nov/Dec;39(6):505-509. doi: 10.1177/1091581820948454. Epub 2020 Aug 14.

Ye, Guo-jie; Budzynski, Ewa; Sonnentag, Peter; Nork, T Michael; Miller, Paul E; Sharma, Alok K; Ver Hoeve, James N; Smith, Leia M; Arndt, Tara; Calcedo, Roberto; Gaskin, Chantelle; Robinson, Paulette M; Knop, David R; Hauswirth, William W; Chulay, Jeffrey D;, Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia. Human gene therapy., Clinical development Vol.27, 2016

Bruning-Barry R, Ambroso JL, Dillberger J, Yang TJ., Toxicity and toxicokinetic assessment of an anti-tubercular drug pretomanid in cynomolgus monkeys, Toxicol Rep. 2022 Apr 22;9:927-936. doi: 10.1016/j.toxrep.2022.04.021.