Cotton rats
Related publications
Infectious disease
Jenkins, T., Wang, R., Harder, O., Xue, M., Chen, P., Corry, J., Walker, C., Teng, M., Mejias, A., Ramilo, O. and Niewiesk, S.,, A novel live attenuated RSV vaccine candidate with mutations in the L protein SAM binding site and the G protein cleavage site is protective in cotton rats and a rhesus macaque., Journal of Virology. 2020.
Harder, Olivia E; Emmer, Kathryn M; Sparks, Amanda E; Miller, Eric J; Gemensky-Metzler, Anne J; Coble, Dondrae J; Niewiesk, Stefan; Perle, Krista M D La, Cause and Treatment of Exophthalmos in Aged Cotton Rats (Sigmodon hispidus), Comparative Medicine. 2020.
Brakel, Kelsey A.; Binjawadagi, Basavaraj; French-Kim, Kristen; Watts, Mauria; Harder, Olivia; Ma, Yuanmei; Li, Jianrong; Niewiesk, Stefan, Coexpression of respiratory syncytial virus (RSV) fusion (F) protein and attachment glycoprotein (G) in a vesicular stomatitis virus (VSV) vector system provides synergistic effects against RSV infection in a cotton rat model, Vaccine. 2021.
Green, Gia; Johnson, Sara M.; Costello, Heather; Brakel, Kelsey; Harder, Olivia; Oomens, Antonius G.; Peeples, Mark E.; Moulton, Hong M.; Niewiesk, Stefan, CX3CR1 Is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats, Journal of Virology. 2021.
Watts DM, Peters CJ, Newman P, Wang N, Yoshikawa N, Tseng CK, Wyde PR., Evaluation of cotton rats as a model for severe acute respiratory syndrome., Vector Borne Zoonotic Dis. 2008 Jun;8(3):339-44.
Hübner, Marc P.; Townson, Simon; Gokool, Suzanne; Tagboto, Senyo; Maclean, Mary J.; Verocai, Guilherme G.; Wolstenholme, Adrian J.; Frohberger, Stefan J.; Hoerauf, Achim; Specht, Sabine; Scandale, Ivan; Harder, Achim; Glenschek-Sieberth, Martin; Hahnel, Steffen R.; Kulke, Daniel, Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside, International Journal for Parasitology: Drugs and Drug Resistance. 2021.
Martinez, Margaret E.; Gonzalez, Cristina Capella; Huey, Devra; Peeples, Mark E.; McCarty, Douglas; Niewiesk, Stefan, Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats, PLOS ONE. 2021.
Wethington, Darren; Harder, Olivia; Uppulury, Karthik; Stewart, William C. L.; Chen, Phylip; King, Tiffany; Reynolds, Susan D.; Perelson, Alan S.; Peeples, Mark E.; Niewiesk, Stefan; Das, Jayajit, Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats, Journal of The Royal Society Interface. 2019.
Lu, Mijia; Zhang, Zijie; Xue, Miaoge; Zhao, Boxuan Simen; Harder, Olivia; Li, Anzhong; Liang, Xueya; Gao, Thomas Z.; Xu, Yunsheng; Zhou, Jiyong; Feng, Zongdi; Niewiesk, Stefan; Peeples, Mark E.; He, Chuan; Li, Jianrong, N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I, Nature Microbiology. 2020.
X Wen, S Mo, S Chen, G Yu, L Gao, S Chen et al., Pathogenic difference of respiratory syncytial virus infection in cotton rats of different ages, Microbial pathogenesis 137 (2019): 103749.
Muralidharan, Abenaya; Larocque, Louise; Russell, Marsha; Creskey, Marybeth; Li, Changgui; Chen, Wangxue; Van Domselaar, Gary; Cao, Jingxin; Cyr, Terry; Rosu-Myles, Michael; Wang, Lisheng; Li, Xuguang, PD-1 of Sigmodon hispidus: Gene identification, characterization and preliminary evaluation of expression in inactivated RSV vaccine-induced enhanced respiratory disease, Scientific Reports. 2019.
Russell, Marsha S.; Thulasi Raman, Sathya N.; Gravel, Caroline; Zhang, Wanyue; Pfeifle, Annabelle; Chen, Wangxue; Van Domselaar, Gary; Safronetz, David; Johnston, Michael; Sauve, Simon; Wang, Lisheng; Rosu-Myles, Michael; Cao, Jingxin; Li, Xuguang, Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton Rats, Frontiers in Immunology. 2021.
Xue, Miaoge; Wang, Rongzhang; Harder, Olivia; Chen, Phylip; Lu, Mijia; Cai, Hui; Li, Anzhong; Liang, Xueya; Jennings, Ryan; Perle, Krista La; Niewiesk, Stefan; Peeples, Mark E.; Li, Jianrong, Stable Attenuation of Human Respiratory Syncytial Virus for Live Vaccines by Deletion and Insertion of Amino Acids in the Hinge Region between the mRNA Capping and Methyltransferase Domains of the Large Polymerase Protein, Journal of Virology. 2020.
Russell, Marsha S.; Creskey, Marybeth; Muralidharan, Abenaya; Li, Changgui; Gao, Jun; Chen, Wangxue; Larocque, Louise; Lavoie, Jessie R.; Farnsworth, Aaron; Rosu-Myles, Michael; Hashem, Anwar M.; Yauk, Carole L.; Cao, Jingxin; Van Domselaar, Gary; Cyr, Terry; Li, Xuguang, Unveiling Integrated Functional Pathways Leading to Enhanced Respiratory Disease Associated With Inactivated Respiratory Syncytial Viral Vaccine, Frontiers in Immunology. 2019.
Xue, Miaoge; Zhao, Boxuan Simen; Zhang, Zijie; Lu, Mijia; Harder, Olivia; Chen, Phylip; Lu, Zhike; Li, Anzhong; Ma, Yuanmei; Xu, Yunsheng; Liang, Xueya; Zhou, Jiyong; Niewiesk, Stefan; Peeples, Mark E.; He, Chuan; Li, Jianrong, Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus, Nature Communications. 2019.
Measles
Bovier, Francesca T.; Rybkina, Ksenia; Biswas, Sudipta; Harder, Olivia; Marcink, Tara C.; Niewiesk, Stefan; Moscona, Anne; Alabi, Christopher A.; Porotto, Matteo, Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein, ACS Nano. 2021.
Mathieu C, Ferren M, Jurgens E, Dumont C, Rybkina K, Harder O, Stelitano D, Madeddu S, Sanna G, Schwartz D, Biswas S, Hardie D, Hashiguchi T, Moscona A, Horvat B, Niewiesk S, Porotto M., Measles Virus Bearing Measles Inclusion Body Encephalitis-
Derived Fusion Protein Is Pathogenic after Infection via the
Respiratory Route, Journal of Virology. April 2019 Volume 93 Issue 8 e01862-18
Parainfluenza Type 3
Outlaw, Victor K.; Cheloha, Ross W.; Jurgens, Eric M.; Bovier, Francesca T.; Zhu, Yun; Kreitler, Dale F.; Harder, Olivia; Niewiesk, Stefan; Porotto, Matteo; Gellman, Samuel H.; Moscona, Anne, Engineering Protease-Resistant Peptides to Inhibit Human Parainfluenza Viral Respiratory Infection, Journal of the American Chemical Society. 2021.
Greninger, Alexander L.; Rybkina, Ksenia; Lin, Michelle J.; Drew-Bear, Jennifer; Marcink, Tara C.; Shean, Ryan C.; Makhsous, Negar; Boeckh, Michael; Harder, Olivia; Bovier, Francesca; Burstein, Shana R.; Niewiesk, Stefan; Rima, Bert K.; Porotto, Matteo; Moscona, Anne, Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence, The Journal of Clinical Investigation. 2021.
