CAR knockout rats
Related publications
ADMET
Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG., Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16Îą-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats., Xenobiotica. 2019 Feb;49(2):227-238.
Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG., Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16Îą-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats., Toxicology. 2018 May 1;400-401:20-27
Forbes KP, Kouranova E, Tinker D, Janowski K, Cortner D, McCoy A, Cui X., Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats., Drug Metab Dispos. 2017 Oct;45(10):1068-1076
Okuda Y, Kushida M, Sumida K, Nagahori H, Nakamura Y, Higuchi H, Kawamura S, Lake BG, Cohen SM, Yamada T., Editor's Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes., Toxicol Sci. 2017 Aug 1;158(2):412-430
Wiemann C, Goettel M, Vardy A, Elcombe BM, Elcombe CR, Chatham LR, Wang H, Li L, Buesen R, Honarvar N, Treumann S, Marxfeld H, Groeters S, Lake BG., Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance., Toxicology. 2019 Oct 1;426:152282.
Cytochrome p450 pathways
Goettel M, Fegert I, Honarvar N, Vardy A, Haines C, Chatham LR, Lake BG., Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats, Toxicology. 2020 Mar 30;433-434:152394. doi: 10.1016/j.tox.2020.152394. Epub 2020 Feb 3.
