C57BL/6 inbred mice
Related publications
Aging
Beccari, S., Valero, J., Maletic-Savatic, M., & Sierra, A. (2017)., A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis., Scientific Reports, 7(1), 16528-017-16466-3. doi:10.1038/s41598-017-16466-3 [doi]
Moro F, Pischiutta F, Portet A, Needham EJ, Norton EJ, Ferdinand JR, Vegliante G, Sammali E, Pascente R, Caruso E, Micotti E, Tolomeo D, di Marco Barros R, Fraunberger E, Wang KKW, Esser MJ, Menon DK, Clatworthy MR, Zanier ER., Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury, Brain Commun. 2022 Feb 16;4(2):fcac036. doi: 10.1093/braincomms/fcac036.
Bauernfeind, F., Niepmann, S., Knolle, P. A., & Hornung, V. (2016)., Aging-associated TNF production primes inflammasome activation and NLRP3-related metabolic disturbances., Journal of Immunology (Baltimore, Md.: 1950), 197(7), 2900-2908. doi:10.4049/jimmunol.1501336 [doi]
McHugh D, Sun B, Gutierrez-Muñoz C, Hernández-González F, Mellone M, Guiho R, Duran I, Pombo J, Pietrocola F, Birch J, Kallemeijn WW, Khadayate S, Dharmalingam G, Vernia S, Tate EW, MartÃnez-Barbera JP, Withers DJ, Thomas GJ, Serrano M, Gil J., COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells., Nat Cell Biol. 2023 Dec;25(12):1804-1820. doi: 10.1038/s41556-023-01287-6. Epub 2023 Nov 27.
Panagiotou, M., Vyazovskiy, V. V., Meijer, J. H., & Deboer, T. (2017)., Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics between young and old mice, Scientific Reports, 7, 43656. doi:10.1038/srep43656 [doi]
Wolf, G., Lotan, A., Lifschytz, T., Ben-Ari, H., Kreisel Merzel, T., Tatarskyy, P., . . . Lerer, B. (2017)., Differentially severe cognitive effects of compromised cerebral blood flow in aged mice: Association with myelin degradation and microglia activation., Frontiers in Aging Neuroscience, 9, 191. doi:10.3389/fnagi.2017.00191 [doi]
Panagiotou, M., Papagiannopoulos, K., Rohling, J. H. T., Meijer, J. H., & Deboer, T. (2018)., How old is your brain? slow-wave activity in non-rapid-eye-movement sleep as a marker of brain rejuvenation after long-term exercise in mice., Frontiers in Aging Neuroscience, 10, 233. doi:10.3389/fnagi.2018.00233 [doi]
Nitzan, Keren; Benhamron, Sandrine; Valitsky, Michael; Kesner, Eyal E; Lichtenstein, Michal; Ben-Zvi, Ayal; Ella, Ezra; Segalstein, Yehudit; Saada, Ann; Lorberboum-Galski, Haya; Rosenmann, Hanna;, Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimers Disease Mice, Journal of Alzheimer's disease : JAD Vol.72, 2019
Cinat D, Souza AL, Soto-Gamez A, Jellema-de Bruin AL, Coppes RP, Barazzuol L., Mitophagy induction improves salivary gland stem/progenitor cell function by reducing senescence after irradiation., Radiother Oncol. 2023 Nov 24;190:110028. doi: 10.1016/j.radonc.2023.110028. [Epub ahead of print]
Delgado-Anglés, A., Blasco-Roset, A., Godoy-Nieto, F. J., Cairó, M., Villarroya, F., Giralt, M., & Villarroya, J., Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice., J Physiol Biochem. 2023 Nov 2. doi: 10.1007/s13105-023-00977-x. [Epub ahead of print]
Davis, H. M., Aref, M. W., Aguilar-Perez, A., Pacheco-Costa, R., Allen, K., Valdez, S., . . . Plotkin, L. I. (2018)., x43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice., JBMR Plus, 2(4), 206-216. doi:10.1002/jbm4.10035 [doi]
Alcoholism
Lopez-Jimenez, A., Walter, N. A., Gine, E., Santos, A., Echeverry-Alzate, V., Buhler, K. M., . . . Lopez-Moreno, J. A. (2013)., A spontaneous deletion of alpha-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: Effects on alcohol consumption., Synapse (New York, N.Y.), 67(6), 280-289. doi:10.1002/syn.21639 [doi]
Tice AL, Laudato JA, Fadool DA, Gordon BS, Steiner JL., Acute binge alcohol alters whole body metabolism and the time-dependent expression of skeletal muscle-specific metabolic markers for multiple days in mice, Am J Physiol Endocrinol Metab. 2022 Sep 1;323(3):E215-E230. doi: 10.1152/ajpendo.00026.2022. Epub 2022 Jul 6.
Ghosh A, Muthuraju S, Badal S, Wooden J, Leasure JL, Roman G, Das J., Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking, Neuroscience. 2022 Apr 1;487:166-183. doi: 10.1016/j.neuroscience.2022.02.008. Epub 2022 Feb 12.
Koskela M, Piepponen TP, Andressoo JO, Võikar V, Airavaara M., Female C57BL/6J Mice Show Alcohol-Seeking Behaviour after Withdrawal from Prolonged Alcohol Consumption in the Social Environment., Alcohol Alcohol. 2021 Apr 24. pii: agab032. doi: 10.1093/alcalc/agab032. [Epub ahead of print]
Laitakari A, Tapio J, Mäkelä KA, Herzig KH, Dengler F, Gylling H, Walkinshaw G, Myllyharju J, Dimova EY, Serpi R, Koivunen P., HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD, J Mol Med (Berl). 2020 May;98(5):719-731. doi: 10.1007/s00109-020-01903-0. Epub 2020 Apr 15.
Gil de Biedma-Elduayen L, Giménez-Gómez P, Morales-Puerto N, Vidal R, Núñez-de la Calle C, Gutiérrez-López MD, O'Shea E, Colado MI., Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice, Br J Pharmacol. 2022 Jul;179(14):3711-3726. doi: 10.1111/bph.15825. Epub 2022 Mar 7.
Pinson MR, Tseng AM, Adams A, Lehman TE, Chung K, Gutierrez J, Larin KV, Chambers C, Miranda RC; Collaborative Initiative on Fetal Alcohol Spectrum Disorders., Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome, Alcohol Clin Exp Res. 2022 Jun;46(6):1036-1049. doi: 10.1111/acer.14846. Epub 2022 May 9.
Boschen KE, Ptacek TS, Berginski ME, Simon JM, Parnell SE., Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol, Dis Model Mech. 2021 Jun 1;14(6):dmm049012. doi: 10.1242/dmm.049012. Epub 2021 Jun 17.
Alpha synuclein
Fassler M, Benaim C, George J., A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties, Cells. 2022 Nov 29;11(23):3822. doi: 10.3390/cells11233822.
Zaltieri, M., Grigoletto, J., Longhena, F., Navarria, L., Favero, G., Castrezzati, S., . . . Bellucci, A. (2015)., Alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons., Journal of Cell Science, 128(13), 2231-2243. doi:10.1242/jcs.157867 [doi]
Zaltieri, M., Grigoletto, J., Longhena, F., Navarria, L., Favero, G., Castrezzati, S., . . . Bellucci, A. (2015)., Alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons., Journal of Cell Science, 128(13), 2231-2243. doi:10.1242/jcs.157867 [doi]
Liron, T., Raphael, B., Hiram-Bab, S., Bab, I. A., & Gabet, Y. (2018), Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes., . Journal of Cellular Physiology, 233(1), 371-377. doi:10.1002/jcp.25895 [doi]
Mahul-Mellier, A. L., Fauvet, B., Gysbers, A., Dikiy, I., Oueslati, A., Georgeon, S., . . . Lashuel, H. A. (2014)., c-abl phosphorylates alpha-synuclein and regulates its degradation: Implication for alpha-synuclein clearance and contribution to the pathogenesis of parkinson's disease., Human Molecular Genetics, 23(11), 2858-2879. doi:10.1093/hmg/ddt674 [doi]
Jonsson, O., Steffen, A. C., Sundquist, V. S., Janson, J., Martinsson, S., Maatta, U., & Emanuelsson, A. B. (2013)., Capillary microsampling and analysis of 4-microl blood, plasma and serum samples to determine human alpha-synuclein elimination rate in mice, Bioanalysis, 5(4), 449-462. doi:10.4155/bio.12.337 [doi]
Weihofen, Andreas; Liu, YuTing; Arndt, Joseph W; Huy, Christian; Quan, Chao; Smith, Benjamin A; Baeriswyl, Jean-Luc; Cavegn, Nicole; Senn, Luzia; Su, Lihe; Marsh, Galina; Auluck, Pavan K; Montrasio, Fabio; Nitsch, Roger M; Hirst, Warren D; Cedarbaum, Jesse M; Pepinsky, R Blake; Grimm, Jan; Weinreb, Paul H, Development of an aggregate-selective, human-derived ?-synuclein-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinsons disease models., Neurobiology of disease Vol.124, 2019
Weihofen, A., Liu, Y., Arndt, J. W., Huy, C., Quan, C., Smith, B. A., . . . Weinreb, P. H. (2018)., Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in parkinson's disease models, Neurobiology of Disease, doi:S0969-9961(18)30448-0 [pii]
Masato A, Plotegher N, Terrin F, Sandre M, Faustini G, Thor A, Adams S, Berti G, Cogo S, De Lazzari F, Fontana CM, Martinez PA, Strong R, Bandopadhyay R, Bisaglia M, Bellucci A, Greggio E, Dalla Valle L, Boassa D, Bubacco L., DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease, NPJ Parkinsons Dis. 2023 Mar 25;9(1):42. doi: 10.1038/s41531-023-00485-1.
Pelkonen, A., Kallunki, P., & Yavich, L. (2013), Effects of exogenous alpha-synuclein on stimulated dopamine overflow in dorsal striatum, Neuroscience Letters, 554, 141-145. doi:10.1016/j.neulet.2013.08.072 [doi]
Garcia-Reitboeck, P., Anichtchik, O., Dalley, J. W., Ninkina, N., Tofaris, G. K., Buchman, V. L., & Spillantini, M. G. (2013), Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra., Experimental Neurology, 248, 541-545. doi:10.1016/j.expneurol.2013.07.015 [doi]
Emanuele, M., Esposito, A., Camerini, S., Antonucci, F., Ferrara, S., Seghezza, S., . . . Chieregatti, E. (2016)., Exogenous alpha-synuclein alters pre- and post-synaptic activity by fragmenting lipid rafts., Ebiomedicine, 7, 191-204. doi:10.1016/j.ebiom.2016.03.038 [doi]
Chadchankar, H., Ihalainen, J., Tanila, H., & Yavich, L. (2012)., Methylphenidate modifies overflow and presynaptic compartmentalization of dopamine via an alpha-synuclein-dependent mechanism., The Journal of Pharmacology and Experimental Therapeutics, 341(2), 484-492. doi:10.1124/jpet.111.189225 [doi]
Kilpeläinen, T. P., Pätsi, H. T., Svarcbahs, R., Julku, U. H., Eteläinen, T. S., Cui, H., Auno, S., Sipari, N., Norrbacka, S., Leino, T. O., Jäntti, M., Myöhänen, T. T., & Wallén, E. A. A., Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alph-Synuclein Mouse Models of Parkinson's Disease., J Med Chem. 2023 Jun 8;66(11):7475-7496. doi: 10.1021/acs.jmedchem.3c00235. Epub 2023 May 29.
Burtscher J, Copin JC, Sandi C, Lashuel HA., Pronounced ?-Synuclein Pathology in a Seeding-Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala, eNeuro. 2020 Aug 17;7(4):ENEURO.0110-20.2020. doi: 10.1523/ENEURO.0110-20.2020. Print 2020 Jul/Aug.
Eteläinen TS, Kilpeläinen TP, Ignatius A, Auno S, De Lorenzo F, Uhari-Väänänen JK, Julku UH, Myöhänen TT., Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model, Neuropharmacology. 2022 Nov 1;218:109213. doi: 10.1016/j.neuropharm.2022.109213. Epub 2022 Aug 12.
Vinueza-Gavilanes R, Bravo-González JJ, Basurco L, Boncristiani C, Fernández-Irigoyen J, SantamarÃa E, Marcilla I, Pérez-Mediavilla A, Luquin MR, Vales A, González-Aseguinolaza G, Aymerich MS, Aragón T, Arrasate M., Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models., Neurobiol Dis. 2023 Jul;183:106166. doi: 10.1016/j.nbd.2023.106166. Epub 2023 May 26.
Bar, R., Boehm-Cagan, A., Luz, I., Kleper-Wall, Y., & Michaelson, D. M. (2017)., The effects of apolipoprotein E genotype, alpha-synuclein deficiency, and sex on brain synaptic and alzheimer's disease-related pathology, Alzheimer's & Dementia (Amsterdam, Netherlands), 10, 1-11. doi:10.1016/j.dadm.2017.08.003 [doi]
Background for Genetically Engineered Mouse Models
Hartman SJ, Weiss MA, Temple HM, Donnelly B, Pasula R, Poling HM, McNeal M, Mohanty SK, Tiao GM., Deletion of Interferon Lambda Receptor Elucidates Susceptibility to the Murine Model of Biliary Atresia., J Interferon Cytokine Res. 2023 Sep;43(9):427-434. doi: 10.1089/jir.2023.0046.
Background for induced and genetically-modified models
Massi L, Hagihara KM, Courtin J, Hinz J, Müller C, Fustiñana MS, Xu C, Karalis N, Lüthi A., Disynaptic specificity of serial information flow for conditioned fear, Sci Adv. 2023 Jan 18;9(3):eabq1637. doi: 10.1126/sciadv.abq1637. Epub 2023 Jan 18.
Ye H, Chen C, Wu H, Zheng K, Martín-Adrados B, Caparros E, Francés R, Nelson LJ, Gómez Del Moral M, Asensio I, Vaquero J, Bañares R, Ávila MA, Andrade RJ, Isabel Lucena M, Martínez-Chantar ML, Reeves HL, Masson S, Blumberg RS, Gracia-Sancho J, Nevzorova YA, Martínez-Naves E, Cubero FJ., Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy, Cell Death Dis. 2022 Feb 10;13(2):143. doi: 10.1038/s41419-022-04580-8.
Hashimoto M, Brito SI, Venner A, Pasqualini AL, Yang TL, Allen D, Fuller PM, Anthony TE., Lateral septum modulates cortical state to tune responsivity to threat stimuli., Cell Rep. 2022 Oct 25;41(4):111521. doi: 10.1016/j.celrep.2022.111521.
Behavior
Humby, T., Cross, E. S., Messer, L., Guerrero, S., & Davies, W. (2016), A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis., Psychoneuroendocrinology, 74, 363-370. doi:S0306-4530(16)30216-5 [pii]
Janecek, E., Waindok, P., Bankstahl, M., & Strube, C. (2017)., Abnormal neurobehaviour and impaired memory function as a consequence of toxocara canis- as well as toxocara cati-induced neurotoxocarosis., PLoS Neglected Tropical Diseases, 11(5), e0005594. doi:10.1371/journal.pntd.0005594 [doi]
Dunlap KR, Laskin GR, Waddell DS, Black AJ, Steiner JL, Vied C, Gordon BS., Aerobic exercise-mediated changes in the expression of glucocorticoid responsive genes in skeletal muscle differ across the day., Mol Cell Endocrinol. 2022 Jun 15;550:111652. doi: 10.1016/j.mce.2022.111652. Epub 2022 Apr 21.
Voikar, V., Krackow, S., Lipp, H. P., Rau, A., Colacicco, G., & Wolfer, D. P. (2018)., Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage., Behavioural Brain Research, 352, 8-22. doi:S0166-4328(17)30962-2 [pii]
Laricchiuta, D., Musella, A., Rossi, S., & Centonze, D. (2014), Behavioral and electrophysiological effects of endocannabinoid and dopaminergic systems on salient stimuli., Frontiers in Behavioral Neuroscience, 8, 183. doi:10.3389/fnbeh.2014.00183 [doi]
Heinla, I., Ahlgren, J., Vasar, E., & Voikar, V. (2018)., Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage - effect of mixed housing in complex environment., Physiology & Behavior, 188, 32-41. doi:S0031-9384(18)30032-5 [pii]
Laricchiuta, D., Rojo, M. L., Rodriguez-Gaztelumendi, A., Ferlazzo, F., Petrosini, L., & Fowler, C. J. (2012)., CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation, PloS One, 7(7), e42111. doi:10.1371/journal.pone.0042111 [doi]
Trott JM, Hoffman AN, Zhuravka I, Fanselow MS., Conditional and unconditional components of aversively motivated freezing, flight and darting in mice, Elife. 2022 May 26;11:e75663. doi: 10.7554/eLife.75663
Noack, J., Murau, R., & Engelmann, M. (2015)., Consequences of temporary inhibition of the medial amygdala on social recognition memory performance in mice, Frontiers in Neuroscience, 9, 152. doi:10.3389/fnins.2015.00152 [doi]
Tam, S. K., Hasan, S., Choi, H. M., Brown, L. A., Jagannath, A., Hughes, S., . . . Peirson, S. N. (2017)., Constant light desynchronizes olfactory versus object and visuospatial recognition memory performance., The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 37(13), 3555-3567. doi:10.1523/JNEUROSCI.3213-16.2017 [doi]
Yaeger JDW, Krupp KT, Summers TR, Summers CH., Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala., Neuropharmacology. 2022 Sep 1;215:109168. doi: 10.1016/j.neuropharm.2022.109168. Epub 2022 Jun 17.
Laricchiuta, D., Rossi, S., Musella, A., De Chiara, V., Cutuli, D., Centonze, D., & Petrosini, L. (2012)., Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission., PloS One, 7(3), e33260. doi:10.1371/journal.pone.0033260 [doi]
Reichenbach, N., Herrmann, U., Kahne, T., Schicknick, H., Pielot, R., Naumann, M., . . . Tischmeyer, W. (2015)., Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain., Proteome Science, 13, 13-015-0069-2. eCollection 2015. doi:10.1186/s12953-015-0069-2 [doi]
Camats-Perna, Judith; Kalaba, Predrag; Ebner, Karl; Sartori, Simone B; Vuyyuru, Harish; Aher, Nilima Y; Draga?evi?, Vladimir; Singewald, Nicolas; Engelmann, Mario; Lubec, Gert;, Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice., Frontiers in behavioral neuroscience Vol.13, 2019
Steel LCE, Tir S, Tam SKE, Bussell JN, Spitschan M, Foster RG, Peirson SN., Effects of Cage Position and Light Transmission on Home Cage Activity and Circadian Entrainment in Mice, Front Neurosci. 2022 Jan 10;15:832535. doi: 10.3389/fnins.2021.832535. eCollection 2021.
Laricchiuta, D., Centonze, D., & Petrosini, L. (2013)., Effects of endocannabinoid and endovanilloid systems on aversive memory extinction., Behavioural Brain Research, 256, 101-107. doi:10.1016/j.bbr.2013.08.010 [doi]
Labots, M., Zheng, X., Moattari, G., Ohl, F., & van Lith, H. A. (2016)., Effects of light regime and substrain on behavioral profiles of male C57BL/6 mice in three tests of unconditioned anxiety, Journal of Neurogenetics, 30(3-4), 306-315. doi:10.1080/01677063.2016.1249868 [doi]
Ehmer I, Crown L, van Leeuwen W, Feenstra M, Willuhn I, Denys D., Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder, eNeuro. 2020 Apr 28;7(2):ENEURO.0245-19.2020. doi: 10.1523/ENEURO.0245-19.2020. Print 2020 Mar/Apr.
de Hoz, L., & Nelken, I. (2014)., Frequency tuning in the behaving mouse: Different bandwidths for discrimination and generalization, PloS One, 9(3), e91676. doi:10.1371/journal.pone.0091676 [doi]
Åhlgren, Johanna; Voikar, Vootele;, Housing mice in the individually ventilated or open cages-Does it matter for behavioral phenotype?, Genes, brain, and behavior Vol.18, 2019
Davies JR, Purawijaya DA, Bartlett JM, Robinson ESJ., Impact of Refinements to Handling and Restraint Methods in Mice, Animals (Basel). 2022 Aug 24;12(17):2173. doi: 10.3390/ani12172173.
Laricchiuta, D., Saba, L., De Bartolo, P., Caioli, S., Zona, C., & Petrosini, L. (2016), Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit., Scientific Reports, 6, 21205. doi:10.1038/srep21205 [doi]
Kulesskaya, N., Karpova, N. N., Ma, L., Tian, L., & Voikar, V. (2014)., Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: Implications for interventions based on social enrichment., Frontiers in Behavioral Neuroscience, 8, 257. doi:10.3389/fnbeh.2014.00257 [doi]
Ahmadlou, M., & Heimel, J. A. (2015)., Preference for concentric orientations in the mouse superior colliculus., Nature Communications, 6, 6773. doi:10.1038/ncomms7773 [doi]
Houben, T., Coomans, C. P., & Meijer, J. H. (2014)., Regulation of circadian and acute activity levels by the murine suprachiasmatic nuclei, PloS One, 9(10), e110172. doi:10.1371/journal.pone.0110172 [doi]
Kopachev N, Netser S, Wagner S., Sex-dependent features of social behavior differ between distinct laboratory mouse strains and their mixed offspring, iScience. 2022 Jan 5;25(2):103735. doi: 10.1016/j.isci.2022.103735. eCollection 2022 Feb 18.
van den Berg, W. E., Lamballais, S., & Kushner, S. A. (2015)., Sex-specific mechanism of social hierarchy in mice., Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 40(6), 1364-1372. doi:10.1038/npp.2014.319 [doi]
de la Zerda SH, Netser S, Magalnik H, Briller M, Marzan D, Glatt S, Abergel Y, Wagner S., Social recognition in laboratory mice requires integration of behaviorally-induced somatosensory, auditory and olfactory cues, Psychoneuroendocrinology. 2022 Sep;143:105859. doi: 10.1016/j.psyneuen.2022.105859. Epub 2022 Jul 5.
Gasser BA, Kurz J, Senn W, Escher G, Mohaupt MG., Stress-induced alterations of social behavior are reversible by antagonism of steroid hormones in C57/BL6 mice, Naunyn Schmiedebergs Arch Pharmacol. 2021 Jan;394(1):127-135. doi: 10.1007/s00210-020-01970-7. Epub 2020 Sep 7.
Odland, Anna U; Jessen, Lea; Kristensen, Jesper L; Fitzpatrick, Ciarán M; Andreasen, Jesper T;, The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation, Neuropharmacology Vol., 2019
O'Brien, F. E., O'Connor, R. M., Clarke, G., Donovan, M. D., Dinan, T. G., Griffin, B. T., & Cryan, J. F. (2014)., The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram., Behavioural Brain Research, 261, 17-25. doi:10.1016/j.bbr.2013.11.027 [doi]
Perna, J. C., Wotjak, C. T., Stork, O., & Engelmann, M. (2015)., Timing of presentation and nature of stimuli determine retroactive interference with social recognition memory in mice., Physiology & Behavior, 143, 10-14. doi:10.1016/j.physbeh.2015.02.029 [doi]
Behavioral and learning disabilities
Bove M, Schiavone S, Tucci P, Sikora V, Dimonte S, Colia AL, Morgese MG, Trabace L., Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms, Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jul 13;117:110560. doi: 10.1016/j.pnpbp.2022.110560. Epub 2022 Apr 20.
Kordás K, Kis-Varga Á, Varga A, Eldering H, Bulthuis R, Lendvai B, Lévay G, Román V., Measuring sociability of mice using a novel three-chamber apparatus and algorithm of the LABORAS⢠system, J Neurosci Methods. 2020 Sep 1;343:108841. doi: 10.1016/j.jneumeth.2020.108841. Epub 2020 Jul 1.
Ronda OAHO, van de Heijning BJM, de Bruin A, Thomas RE, Martini I, Koehorst M, Gerding A, Koster MH, Bloks VW, Jurdzinski A, Mulder NL, Havinga R, van der Beek EM, Reijngoud DJ, Kuipers F, Verkade HJ., Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet, PLoS One. 2020 Sep 21;15(9):e0232069. doi: 10.1371/journal.pone.0232069. eCollection 2020.
Mekada K, Yoshiki A., Substrains matter in phenotyping of C57BL/6 mice, Exp Anim. 2021 May 13;70(2):145-160. doi: 10.1538/expanim.20-0158. Epub 2021 Jan 14.
Ericsson AC, Hart ML, Kwan J, Lanoue L, Bower LR, Araiza R, Kent Lloyd KC, Franklin CL., Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism, Commun Biol. 2021 Jun 10;4(1):716. doi: 10.1038/s42003-021-02249-0.
Cardiovascular
Schwaerzer GK, Casteel DE, Cividini F, Kalyanaraman H, Zhuang S, Gu Y, Dalton ND, Peterson KL, Dillmann WH, Boss GR, Pilz RB., Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy, Br J Pharmacol. 2021 May 17. doi: 10.1111/bph.15530. Online ahead of print.
Gurgen, D., Kusch, A., Klewitz, R., Hoff, U., Catar, R., Hegner, B., . . . Dragun, D. (2013)., Dragun, D. (2013). Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model., Hypertension, 61(3), 730-736. doi:10.1161/HYPERTENSIONAHA.111.00276 [doi]
Case, A. J., Tian, J., & Zimmerman, M. C. (2017)., Increased mitochondrial superoxide in the brain, but not periphery, sensitizes mice to angiotensin II-mediated hypertension., Redox Biology, 11, 82-90. doi:S2213-2317(16)30268-3 [pii]
Tolonen, A. M., Magga, J., Szabo, Z., Viitala, P., Gao, E., Moilanen, A. M., . . . Serpi, R. (2014)., Inhibition of let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice., Pharmacology Research & Perspectives, 2(4), e00056. doi:10.1002/prp2.56 [doi]
Zhou Z, Liu Z, Gao X, Long Q., Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction, J Bioenerg Biomembr. 2021 Apr;53(2):119-127. doi: 10.1007/s10863-021-09884-6. Epub 2021 Feb 25.
Thielen NT, Kleinsasser AA, Freeling JL., Myocardial contrast echocardiography assessment of mouse myocardial infarction: comparison of kinetic parameters with conventional methods, PeerJ. 2021 Jun 1;9:e11500. doi: 10.7717/peerj.11500. eCollection 2021.
Yin D, Wang C, Qi Y, Wang YC, Hagemann N, Mohamud Yusuf A, Dzyubenko E, Kaltwasser B, Tertel T, Giebel B, Gunzer M, Popa-Wagner A, Doeppner TR, Hermann DM., Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages., J Neuroinflammation. 2023 Sep 15;20(1):210. doi: 10.1186/s12974-023-02894-8.
Mutikainen, M., Tuomainen, T., Naumenko, N., Huusko, J., Smirin, B., Laidinen, S., . . . Tavi, P. (2016)., Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling., The Journal of Physiology, 594(23), 7049-7071. doi:10.1113/JP272847 [doi]
Hoek-van den Hil, E. F., Keijer, J., Bunschoten, A., Vervoort, J. J., Stankova, B., Bekkenkamp, M., . . . van Schothorst, E. M. (2013)., Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice., PloS One, 8(1), e51588. doi:10.1371/journal.pone.0051588 [doi]
Ruiz-Velasco, A., Raja, R., Chen, X., Ganenthiran, H., Kaur, N., Alatawi, N. H. O., Miller, J. M., Abouleisa, R. R. E., Ou, Q., Zhao, X., Fonseka, O., Wang, X., Hille, S. S., Frey, N., Wang, T., Mohamed, T. M. A., Müller, O. J., Cartwright, E. J., & Liu, W., Restored autophagy is protective against PAK3-induced cardiac dysfunction, iScience, 26(6), 106970. https://doi.org/10.1016/j.isci.2023.106970
Guilbeau-Frugier, C., Cauquil, M., Karsenty, C., Lairez, O., Dambrin, C., Payre, B., . . . Gales, C. (2018)., Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues. Cardiovascular Research, doi:10.1093/cvr/cvy256 [doi], Cardiovascular Research, doi:10.1093/cvr/cvy256 [doi]
Tijsen, A. J., van der Made, I., van den Hoogenhof, M. M., Wijnen, W. J., van Deel, E. D., de Groot, N. E., . . . Creemers, E. E. (2014)., The microRNA-15 family inhibits the TGFbeta-pathway in the heart., Cardiovascular Research, 104(1), 61-71. doi:10.1093/cvr/cvu184 [doi]
COVID-19
Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, et al., A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses, bioRxiv 2020.08.31.275701; doi: https://doi.org/10.1101/2020.08.31.275701
Ghebremedhin A, Salam AB, Adu-Addai B, Noonan S, Stratton R, Ahmed MSU, Khantwal C, Martin GR, Lin H, Andrews C, Karanam B, Rudloff U, Lopez H, Jaynes J, Yates C., A Novel CD206 Targeting Peptide Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice, bioRxiv. 2020 Jul 29:2020.07.27.218115. doi: 10.1101/2020.07.27.218115. Preprint.
Mirchandani AS, Jenkins SJ, Bain CC, Sanchez-Garcia MA, Lawson H, Coelho P, Murphy F, Griffith DM, Zhang A, Morrison T, Ly T, Arienti S, Sadiku P, Watts ER, Dickinson RS, Reyes L, Cooper G, Clark S, Lewis D, Kelly V, Spanos C, Musgrave KM, Delaney L, Harper I, Scott J, Parkinson NJ, Rostron AJ, Baillie JK, Clohisey S, Pridans C, Campana L, Lewis PS, Simpson AJ, Dockrell DH, Schwarze J, Hirani N, Ratcliffe PJ, Pugh CW, Kranc K, Forbes SJ, Whyte MKB, Walmsley SR., Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation., Nat Immunol. 2022 Jun;23(6):927-939. doi: 10.1038/s41590-022-01216-z. Epub 2022 May 27. Erratum in: Nat Immunol. 2022 Jul 19.
Schumann S, Kaiser A, Nicoletti F, Mangano K, Fagone P, van Wijk E, Yan Y, Schulz P, Ludescher B, Niedermaier M, von Wegerer J, Rauch P, Setz C, Schubert U, Brysch W., Immune-Modulating Drug MP1032 with SARS-CoV-2 Antiviral Activity In Vitro: A potential Multi-Target Approach for Prevention and Early Intervention Treatment of COVID-19, Int J Mol Sci. 2020 Nov 20;21(22):8803. doi: 10.3390/ijms21228803.
D’Alessio F, Lione L, Salvatori E, Bucci F, Muzi A, Roscilli G…Palombo F., Immunogenicity of COVID-eVax Is Moderately Impacted by Temperature and Molecular Isoforms, bioRxiv 2022.12.29.522202
Chen M, Rosenberg J, Cai X, Hsuan Lee AC, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J., Nanotraps for the containment and clearance of SARS-CoV-2, Matter. 2021 Jun 2;4(6):2059-2082. doi: 10.1016/j.matt.2021.04.005. Epub 2021 Apr 22.
Stanelle-Bertram, S., Schaumburg, B., Kouassi, N. M., Beck, S., Zickler, M., Beythien, G., ... & dos Reis, V. P., SARS-CoV-2 induced CYP19A1 expression in the lung correlates with increased aromatization of testosterone-to-estradiol in male golden hamsters, Research Square, 20 Nov 2020. DOI: 10.21203/rs.3.rs-107474/v1
Singh V, Beer A, Kraus A, et al., Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs, bioRxiv 2020.06.24.162941; doi: https://doi.org/10.1101/2020.06.24.162941
Ye G, Gallant JP, Massey C, Shi K, Tai W, Zheng J, Odle AE, Vickers MA, Shang J, Wan Y, Drelich A, Kempaiah KR, Tat V, Perlman S, Du L, Tseng CT, Aihara H, LeBeau AM, Li F., The Development of a Novel Nanobody Therapeutic for SARS-CoV-2, bioRxiv. 2020 Nov 17:2020.11.17.386532. doi: 10.1101/2020.11.17.386532. Preprint.
Diabetes type 2
Si R, Cabrera JTO, Tsuji-Hosokawa A, Guo R, Watanabe M, Gao L, Lee YS, Moon JS, Scott BT, Wang J, Ashton AW, Rao JN, Wang JY, Yuan JX, Makino A., HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes, JCI Insight. 2021 Nov 8;6(21):e147982. doi: 10.1172/jci.insight.147982.
Roesti ES, Boyle CN, Zeman DT, Sande-Melon M, Storni F, Cabral-Miranda G, Knuth A, Lutz TA, Vogel M, Bachmann MF., Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus, Vaccines (Basel). 2020 Mar 2;8(1):116. doi: 10.3390/vaccines8010116.
Diet induced obesity
Umek, Nejc; Horvat, Simon; Cvetko, Erika; Kreft, Marko; JanĂĄ?ek, Ji?Ă ; KubĂnovĂĄ, Lucie; Stopar Pintari?, Tatjana; ErĹžen, Ida;, 3D analysis of capillary network in skeletal muscle of obese insulin-resistant mice., Histochemistry and cell biology Vol.152, 2019
Duivenvoorde, L. P., van Schothorst, E. M., Swarts, H. M., Kuda, O., Steenbergh, E., Termeulen, S., . . . Keijer, J. (2015), A difference in fatty acid composition of isocaloric high-fat diets alters metabolic flexibility in male C57BL/6JOlaHsd mice., PloS One, 10(6), e0128515. doi:10.1371/journal.pone.0128515 [doi]
Fernández-Calleja, José M S; Bouwman, Lianne M S; Swarts, Hans J M; Billecke, Nils; Oosting, Annemarie; Keijer, Jaap; van Schothorst, Evert M, A Lowly Digestible-Starch Diet after Weaning Enhances Exogenous Glucose Oxidation Rate in Female, but Not in Male, Mice., Nutrients Vol.11, 2019
Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS., A rare human variant that disrupts GPR10 signalling causes weight gain in mice., Nat Commun. 2023 Mar 15;14(1):1450. doi: 10.1038/s41467-023-36966-3.
Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., . . . Pirola, L. (2015), Adipose tissue-derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1/Th17 balance and monocyte activation., Diabetes, 64(7), 2477-2488. doi:10.2337/db15-0162 [doi]
McPherson, N. O., Lane, M., Sandeman, L., Owens, J. A., & Fullston, T. (2017)., An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and MicroRNA expression in male offspring., Nutrients, 9(2), 10.3390/nu9020122. doi:E122 [pii]
Anagnostopoulos G, Motiño O, Li S, Carbonnier V, Chen H, Sica V, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Donne R, Desdouets C, Sola MS, Kotta K, Montégut L, Lambertucci F, Surdez D, Sandrine G, Delattre O, Maiuri MC, Bravo-San Pedro JM, Martins I, Kroemer G. , An obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABAA receptor., Cell Death Dis. 2022 Apr 18;13(4):356. doi: 10.1038/s41419-022-04834-5. Erratum in: Cell Death Dis. 2022 May 3;13(5):430.
Worley BL, Auen T, Arnold AC, Monia BP, Hempel N, Czyzyk TA., Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice, Physiol Rep. 2021 May;9(9):e14853. doi: 10.14814/phy2.14853.
Charlot A, Charles A-L, Georg I, Goupilleau F, Debrut L, Pizzimenti M, Mallard J, Pagano AF, Geny B, Zoll J., Beneficial Effects of Ketogenic Diet on Nonalcoholic Steatohepatitis in Obese Mice Model, Biology and Life Sciences Forum. 2022; 12(1):23. https://doi.org/10.3390/IECN2022-12368
Parra-Vargas, M., Sandoval-Rodriguez, A., Rodriguez-Echevarria, R., Dominguez-Rosales, J. A., Santos-Garcia, A., & Armendariz-Borunda, J. (2018)., Delphinidin ameliorates hepatic triglyceride accumulation in human HepG2 cells, but not in diet-induced obese mice., Nutrients, 10(8), 10.3390/nu10081060. doi:E1060 [pii]
Hoek-van den Hil, E. F., van Schothorst, E. M., van der Stelt, I., Swarts, H. J., van Vliet, M., Amolo, T., . . . Keijer, J. (2015), Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice., Genes & Nutrition, 10(4), 469-015-0469-z. Epub 2015 May 29. doi:10.1007/s12263-015-0469-z [doi]
Shi, W., Hegeman, M. A., van Dartel, D. A. M., Tang, J., Suarez, M., Swarts, H., . . . Keijer, J. (2017)., Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet., Molecular Nutrition & Food Research, 61(8), 10.1002/mnfr.201600878. Epub 2017 Apr 13. doi:10.1002/mnfr.201600878 [doi]
Lombardo, G. E., Lepore, S. M., Morittu, V. M., Arcidiacono, B., Colica, C., Procopio, A., . . . Celano, M. (2018)., Effects of oleacein on high-fat diet-dependent steatosis, weight gain, and insulin resistance in mice., Frontiers in Endocrinology, 9, 116. doi:10.3389/fendo.2018.00116 [doi]
Ageeli RY, Sharma S, Puppa M, Bloomer RJ, Buddington RK, van der Merwe M., Fasting Protocols Do Not Improve Intestinal Architecture and Immune Parameters in C57BL/6 Male Mice Fed a High Fat Diet., Medicines (Basel). 2023 Feb 17;10(2). pii: 18. doi: 10.3390/medicines10020018.
Sun P, Bouwman LMS, de Deugd JL, van der Stelt I, Oosting A, Keijer J, van Schothorst EM., Galactose in the Post-Weaning Diet Programs Improved Circulating Adiponectin Concentrations and Skeletal Muscle Insulin Signaling, Int J Mol Sci. 2022 Sep 6;23(18):10207. doi: 10.3390/ijms231810207.
Gandasi NR, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, Basco D, Benrick A, Chibalina MV, Clark A, Guida C, Harris M, Johnson PRV, Knudsen JG, Ma J, Miranda C, Shigeto M, Tarasov AI, Yeung HY, Thorens B, Asterholm IW, Zhang Q, et al., GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion., Diabetologia. 2023 Dec 21. doi: 10.1007/s00125-023-06060-w. [Epub ahead of print]
Villalpando-Arteaga, E. V., Mendieta-Condado, E., Esquivel-Solis, H., Canales-Aguirre, A. A., Galvez-Gastelum, F. J., Mateos-Diaz, J. C., . . . Marquez-Aguirre, A. L. (2013)., Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-gamma and SREBP-1c in diet-induced obese mice., Food & Function, 4(4), 618-626. doi:10.1039/c3fo30270a [doi]
Shi, Wenbiao; Hegeman, Maria A; Doncheva, Atanaska; Bekkenkamp-Grovenstein, Melissa; de Boer, Vincent C J; Keijer, Jaap;, High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet, Nutrients Vol.11, 2019
Kothari, V., Luo, Y., Tornabene, T., O'Neill, A. M., Greene, M. W., Geetha, T., & Babu, J. R. (2017)., High fat diet induces brain insulin resistance and cognitive impairment in mice. Biochimica Et Biophysica Acta, Molecular Basis of Disease, 1863(2), 499-508. doi:S0925-4439(16)30250-2 [pii]
Funjika E, Colombo SAP, Hayes KS, Tozer MJ, Tyrrell KA, Cai S, Faniyi AA, Shears RK, Dooley M, Alshammari Y, Alhazmi W, Assas M, Almilaibary A, Jackson-Jones LH, Thornton DJ, Worthington JJ, Grencis RK., High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity., Mucosal Immunol. 2023 Feb;16(1):27-38. doi: 10.1016/j.mucimm.2023.01.004. Epub 2023 Jan 20.
Vial, G., Chauvin, M. A., Bendridi, N., Durand, A., Meugnier, E., Madec, A. M., . . . Rieusset, J. (2015)., Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model., Diabetes, 64(6), 2254-2264. doi:10.2337/db14-1220 [doi]
Khan, I. M., Perrard, X. Y., Brunner, G., Lui, H., Sparks, L. M., Smith, S. R., . . . Ballantyne, C. M. (2015)., Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance, International Journal of Obesity (2005), 39(11), 1607-1618. doi:10.1038/ijo.2015.104 [doi]
Hermier, Dominique; Lan, Annaïg; Tellier, Frédérique; Blais, Anne; Culetto, Marta Grauso; Mathé, Véronique; Bellec, Yannick; Gissot, Lionel; Schmidely, Philippe; Faure, Jean-Denis;, Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice, Journal of agricultural and food chemistry Vol.5, 2020
van der Stelt, I., Hoevenaars, F., Siroka, J., de Ronde, L., Friedecky, D., Keijer, J., & van Schothorst, E. (2017), Metabolic response of visceral white adipose tissue of obese mice exposed for 5 days to human room temperature compared to mouse thermoneutrality., Frontiers in Physiology, 8, 179. doi:10.3389/fphys.2017.00179 [doi]
Derous, D., Kelder, T., van Schothorst, E. M., van Erk, M., Voigt, A., Klaus, S., . . . Radonjic, M. (2015)., Network-based integration of molecular and physiological data elucidates regulatory mechanisms underlying adaptation to high-fat diet., Genes & Nutrition, 10(4), 470-015-0470-6. Epub 2015 May 28. doi:10.1007/s12263-015-0470-6 [doi]
Bouwman, L. M. S., Fernandez-Calleja, J. M. S., Swarts, H. J. M., van der Stelt, I., Oosting, A., Keijer, J., & van Schothorst, E. M. (2018), No adverse programming by post-weaning dietary fructose of body weight, adiposity, glucose tolerance, or metabolic flexibility., Molecular Nutrition & Food Research, 62(2), 10.1002/mnfr.201700315. Epub 2017 Dec 11. doi:10.1002/mnfr.201700315 [doi]
Lombardo, G. E., Arcidiacono, B., De Rose, R. F., Lepore, S. M., Costa, N., Montalcini, T., . . . Celano, M. (2016)., Normocaloric diet restores weight gain and insulin sensitivity in obese mice., Frontiers in Endocrinology, 7, 49. doi:10.3389/fendo.2016.00049 [doi]
Manfrevola F, Chioccarelli T, Mele VG, Porreca V, Mattia M, Cimini D, D'Agostino A, Cobellis G, Fasano S, Schiraldi C, Chianese R, Pierantoni R., Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice., Int J Mol Sci. 2023 Apr 6;24(7). pii: 6865. doi: 10.3390/ijms24076865.
Donkers, Joanne M; Kooijman, Sander; Slijepcevic, Davor; Kunst, Roni F; Roscam Abbing, Reinout Lp; Haazen, Lizette; de Waart, Dirk R; Levels, Johannes Hm; Schoonjans, Kristina; Rensen, Patrick Cn; Oude Elferink, Ronald Pj; van de Graaf, Stan Fj;, NTCP deficiency in mice protects against obesity and hepatosteatosis., JCI insight Vol.5, 2019
Lepore, Saverio Massimo; Maggisano, Valentina; Bulotta, Stefania; Mignogna, Chiara; Arcidiacono, Biagio; Procopio, Antonio; Brunetti, Antonio; Russo, Diego; Celano, Marilena, Oleacein Prevents High Fat Diet-Induced Adiposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice, Nutrients Vol.11, 2019
Jurrissen, Thomas J; Grunewald, Zachary I; Woodford, Makenzie L; Winn, Nathan C; Ball, James R; Smith, Thomas N; Wheeler, Andrew A; Rawlings, Arthur L; Staveley-OCarroll, Kevin F; Ji, Yan; Fay, William P; Paradis, Pierre; Schiffrin, Ernesto L; Vieira-Potter, Victoria J; Fadel, Paul J; Martinez-Lemus, Luis A; Padilla, Jaume;, Overproduction of endothelin-1 impairs glucose tolerance but does not promote visceral adipose tissue inflammation or limit metabolic adaptations to exercise., American journal of physiology. Endocrinology and metabolism Vol.317, 2019
Duivenvoorde, L. P., van Schothorst, E. M., Derous, D., van der Stelt, I., Masania, J., Rabbani, N., . . . Keijer, J. (2015)., Oxygen restriction as challenge test reveals early high-fat-diet-induced changes in glucose and lipid metabolism., Pflugers Archiv : European Journal of Physiology, 467(6), 1179-1193. doi:10.1007/s00424-014-1553-8 [doi]
Coulter-Parkhill A, Gault VA, McClean S, Irwin N., Peptides originally derived from Chilobrachys jingzhao tarantula venom possess beneficial effects on pancreatic beta cell health and function., Eur J Pharmacol. 2023 Sep 5;954:175855. doi: 10.1016/j.ejphar.2023.175855. Epub 2023 Jun 28.
Dhandapani, Praveen K; Lyyski, Annina M; Paulin, Lars; Khan, Nahid A; Suomalainen, Anu; Auvinen, Petri; Dufour, Eric; Szibor, Marten; Jacobs, Howard T;, Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice, Physiological reports Vol.7, 2019
Terzo S, Calvi P, Giardina M, Gallizzi G, Di Carlo M, Nuzzo D, Picone P, Puleio R, Mulè F, Scoglio S, Amato A., Positive Impacts of Aphanizomenon Flos Aquae Extract on Obesity-Related Dysmetabolism in Mice with Diet-Induced Obesity., Cells. 2023 Nov 25;12(23). pii: 2706. doi: 10.3390/cells12232706.
Ronda, Onne A H O; van de Heijning, Bert J M; de Bruin, Alain; Jurdzinski, Angelika; Kuipers, Folkert; Verkade, Henkjan J;, Programming effects of an early life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet, The British journal of nutrition Vol.122, 2019
Gutman, Roee; Rauch, Maayan; Neuman, Annat; Khamaisi, Hazem; Jonas-Levi, Adi; Konovalova, Yelena; Rytwo, Giora;, Sepiolite Clay Attenuates the Development of Hypercholesterolemia and Obesity in Mice Fed a High-Fat High-Cholesterol Diet., Journal of medicinal food Vol.5, 2019
Voigt, A., Agnew, K., van Schothorst, E. M., Keijer, J., & Klaus, S. (2013)., Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes., Molecular Nutrition & Food Research, 57(8), 1423-1434. doi:10.1002/mnfr.201200671 [doi]
Fullston, T., Ohlsson-Teague, E. M., Print, C. G., Sandeman, L. Y., & Lane, M. (2016)., Sperm microRNA content is altered in a mouse model of male obesity, but the same suite of microRNAs are not altered in offspring's sperm., PloS One, 11(11), e0166076. doi:10.1371/journal.pone.0166076 [doi]
Pisani, D. F., Ghandour, R. A., Beranger, G. E., Le Faouder, P., Chambard, J. C., Giroud, M., . . . Amri, E. Z. (2014)., The omega6-fatty acid, arachidonic acid, regulates the conversion of white to brite adipocyte through a prostaglandin/calcium mediated pathway., Molecular Metabolism, 3(9), 834-847. doi:10.1016/j.molmet.2014.09.003 [doi]
Hoevenaars, F. P., Bekkenkamp-Grovenstein, M., Janssen, R. J., Heil, S. G., Bunschoten, A., Hoek-van den Hil, E. F., . . . Keijer, J. (2014)., Thermoneutrality results in prominent diet-induced body weight differences in C57BL/6J mice, not paralleled by diet-induced metabolic differences, Molecular Nutrition & Food Research, 58(4), 799-807. doi:10.1002/mnfr.201300285 [doi]
Shi, Wenbiao; Hegeman, Maria A; Doncheva, Atanaska; van der Stelt, Inge; Bekkenkamp-Grovenstein, Melissa; van Schothorst, Evert M; Brenner, Charles; de Boer, Vincent C J; Keijer, Jaap;, Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3, Molecular nutrition & food research Vol.11, 2019
Hoevenaars, Femke P M; Keijer, Jaap; van der Stelt, Inge; Duivenvoorde, Loes P M; Herreman, Laure; van Nes, Robin; FriedeckĂ˝, David; Hegeman, Maria A; van Schothorst, Evert M;, White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation., Genes Vol.10, 2019
Drug Addiction
Garcia-Cabrerizo R, Barros-Santos T, Campos D, Cryan JF., The gut microbiota alone and in combination with a social stimulus regulates cocaine reward in the mouse., Brain Behav Immun. 2023 Jan;107:286-291. doi: 10.1016/j.bbi.2022.10.020. Epub 2022 Oct 28.
General studies
Moore, Scott Emory; Voss, Joachim G; St Pierre Schneider, Barbara;, 17?-estradiol alters mRNA co-expression after murine muscle injury and mild hypobaria., Experimental biology and medicine (Maywood, N.J.) Vol.244, 2019
Schuh KM, Ahmed J, Kwak E, Xu CX, Davis TT, Aronoff CB, Tronson NC., A mouse model of oral contraceptive exposure: Depression, motivation, and the stress response., Horm Behav. 2023 Dec 6;158:105470. doi: 10.1016/j.yhbeh.2023.105470. [Epub ahead of print]
Kinnear HM, Constance ES, David A, Marsh EE, Padmanabhan V, Shikanov A, Moravek MB., A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men, Hum Reprod. 2019 Oct 2;34(10):2009-2017. doi: 10.1093/humrep/dez177.
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Gordon BS, Rossetti ML, Casero RA Jr., Spermidine is not an independent factor regulating limb muscle mass in mice following androgen deprivation, Appl Physiol Nutr Metab. 2021 May;46(5):452-460. doi: 10.1139/apnm-2020-0404. Epub 2020 Oct 30.
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Xiao, Ling; Engen, Phillip A; Leusink-Muis, Thea; van Ark, Ingrid; Stahl, Bernd; Overbeek, Saskia A; Garssen, Johan; Naqib, Ankur; Green, Stefan J; Keshavarzian, Ali; Folkerts, Gert; Vant Land, Belinda;, The Combination of 2-Fucosyllactose with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides that Enhance Influenza Vaccine Responses Is Associated with Mucosal Immune Regulation in Mice., The Journal of nutrition Vol.149, 2019
Lei, Y. M., Chen, L., Wang, Y., Stefka, A. T., Molinero, L. L., Theriault, B., . . . Alegre, M. L. (2016). The composition of the microbiota modulates allograft rejection., The composition of the microbiota modulates allograft rejection., The Journal of Clinical Investigation, 126(7), 2736-2744. doi:10.1172/JCI85295 [doi]
Simonovitch, Shira; Schmukler, Eran; Masliah, Eliezer; Pinkas-Kramarski, Ronit; Michaelson, Daniel M;, The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo, Journal of Alzheimer's disease : JAD Vol.70, 2019
Knop, Jelle; van IJzendoorn, Marinus H; Bakermans-Kranenburg, Marian J; JoĂŤls, Marian; van der Veen, Rixt;, The effects of different rearing conditions on sexual maturation and maternal care in heterozygous mineralocorticoid receptor knockout mice., Hormones and behavior Vol.112, 2019
van der Stelt I, Shi W, Bekkenkamp-Grovenstein M, Zapata-Pérez R, Houtkooper RH, de Boer VCJ, Hegeman MA, Keijer J., The female mouse is resistant to mild vitamin B(3) deficiency., Eur J Nutr. 2021 Aug 2. doi: 10.1007/s00394-021-02651-8. [Epub ahead of print]
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Doron-Mandel E, Koppel I, Abraham O, Rishal I, Smith TP, Buchanan CN, Sahoo PK, Kadlec J, Oses-Prieto JA, Kawaguchi R, Alber S, Zahavi EE, Di Matteo P, Di Pizio A, Song DA, Okladnikov N, Gordon D, Ben-Dor S, Haffner-Krausz R, Coppola G, Burlingame AL, Jungwirth P, Twiss JL, Fainzilber M., The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization, EMBO J. 2021 Oct 18;40(20):e107158. doi: 10.15252/embj.2020107158. Epub 2021 Sep 13.
Moskowitz, Jacob E; Andreatta, Federica; Amos-Landgraf, James;, The gut microbiota modulates differential adenoma suppression by B6/J and B6/N genetic backgrounds in ApcMin mice., Mammalian genome : official journal of the International Mammalian Genome Society Vol.30, 2019
Fransen, F., van Beek, A. A., Borghuis, T., Meijer, B., Hugenholtz, F., van der Gaast-de Jongh, C., . . . de Vos, P. (2017)., The impact of gut microbiota on gender-specific differences in immunity., Frontiers in Immunology, 8, 754. doi:10.3389/fimmu.2017.00754 [doi]
Suárez-Rojas I, Pérez-Fernández M, Bai X, MartÃnez-Martel I, Intagliata S, Pittalà V, Salerno L, Pol O., The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated., Antioxidants (Basel). 2023 Oct 13;12(10). pii: 1859. doi: 10.3390/antiox12101859.
Dafni, Hagit; Greenfeld, Lea; Oren, Roni; Harmelin, Alon;, The Likelihood of Misidentifying Rodent Pasteurellaceae by Using Results from a Single PCR Assay, Journal of the American Association for Laboratory Animal Science : JAALAS Vol.58, 2019
Sakhneny L, Mueller L, Schonblum A, Azaria S, Burganova G, Epshtein A, Isaacson A, Wilson H, Spagnoli FM, Landsman L., The postnatal pancreatic microenvironment guides beta cell maturation through BMP4 production., Dev Cell. 2021 Oct 11;56(19):2703-2711.e5. doi: 10.1016/j.devcel.2021.08.014. Epub 2021 Sep 8.
Salomon-Zimri, Shiran; Koren, Amit; Angel, Ariel; Ben-Zur, Tali; Offen, Daniel; Michaelson, Daniel M;, The Role of MAPKs Signaling in Mediating ApoE4-Driven Pathology In Vivo., Current Alzheimer research Vol.16, 2019
Kivela, R., Salmela, I., Nguyen, Y. H., Petrova, T. V., Koistinen, H. A., Wiener, Z., & Alitalo, K. (2016), The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation., Nature Communications, 7, 13124. doi:10.1038/ncomms13124 [doi]
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Mayshar Y, Raz O, Cheng S, Ben-Yair R, Hadas R, Reines N, Mittnenzweig M, Ben-Kiki O, Lifshitz A, Tanay A, Stelzer Y., Time-aligned hourglass gastrulation models in rabbit and mouse., Cell. 2023 Jun 8;186(12):2610-2627.e18. doi: 10.1016/j.cell.2023.04.037. Epub 2023 May 19.
Farack, Lydia; Golan, Matan; Egozi, Adi; Dezorella, Nili; Bahar Halpern, Keren; Ben-Moshe, Shani; Garzilli, Immacolata; TĂłth, BeĂĄta; Roitman, Lior; Krizhanovsky, Valery; Itzkovitz, Shalev;, Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas., Developmental cell Vol.48, 2019
Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ., Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition, Dev Cell. 2021 Feb 8;56(3):356-365.e9. doi: 10.1016/j.devcel.2020.12.020. Epub 2021 Jan 22.
Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, et al., Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases., Nat Commun. 2023 Aug 28;14(1):5247. doi: 10.1038/s41467-023-40937-z.
Resnik, Nataša; Erman, Andreja; Veranič , Peter; Kreft, Mateja Erdani;, Triple labelling of actin filaments, intermediate filaments and microtubules for broad application in cell biology: uncovering the cytoskeletal composition in tunneling nanotubes, Histochemistry and cell biology Vol.152, 2019
Jaric I, Voelkl B, Amrein I, Wolfer DP, Novak J, Detotto C, Weber-Stadlbauer U, Meyer U, Manuella F, Mansuy IM, Würbel H., Using mice from different breeding sites fails to improve replicability of results from single-laboratory studies., Lab Anim (NY). 2024 Jan;53(1):18-22. doi: 10.1038/s41684-023-01307-w. Epub 2023 Dec 27.
Duale N, Eide DM, Amberger ML, Graupner A, Brede DA, Olsen AK., Using prediction models to identify miRNA-based markers of low dose rate chronic stress, Sci Total Environ. 2020 May 15;717:137068. doi: 10.1016/j.scitotenv.2020.137068. Epub 2020 Feb 4.
Wolf, Yochai; Bartok, Osnat; Patkar, Sushant; Eli, Gitit Bar; Cohen, Sapir; Litchfield, Kevin; Levy, Ronen; JimĂŠnez-SĂĄnchez, Alejandro; Trabish, Sophie; Lee, Joo Sang; Karathia, Hiren; Barnea, Eilon; Day, Chi-Ping; Cinnamon, Einat; Stein, Ilan; Solomon, Adam; Bitton, Lital; PĂŠrez-Guijarro, Eva; Dubovik, Tania; Shen-Orr, Shai S; Miller, Martin L; Merlino, Glenn; Levin, Yishai; Pikarsky, Eli; Eisenbach, Lea; Admon, Arie; Swanton, Charles; Ruppin, Eytan; Samuels, Yardena;, UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma, Cell Vol.179, 2019
Tsai, P. P., Nagelschmidt, N., Kirchner, J., Stelzer, H. D., & Hackbarth, H. (2012)., Validation of an automatic system (DoubleCage) for detecting the location of animals during preference tests., Laboratory Animals, 46(1), 81-84. doi:10.1258/la.2011.011072 [doi]
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Genetically modified
Kohler, C., Dinekov, M., & Gotz, J. (2013)., Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice., Neurobiology of Aging, 34(5), 1369-1379. doi:10.1016/j.neurobiolaging.2012.11.010 [doi]
Ataca, D., Caikovski, M., Piersigilli, A., Moulin, A., Benarafa, C., Earp, S. E., . . . Brisken, C. (2016)., Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development, Biology Open, 5(11), 1585-1594. doi:10.1242/bio.019711 [doi]
Dawson, N., Kurihara, M., Thomson, D. M., Winchester, C. L., McVie, A., Hedde, J. R., . . . Pratt, J. A. (2015)., Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated disrupted-in-schizophrenia 1, Translational Psychiatry, 5, e569. doi:10.1038/tp.2015.60 [doi]
Nasser, A., Moller, L. B., Olesen, J. H., Konradsen, L. S., & Andreasen, J. T. (2014)., Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin, Neuroscience Research, 89, 44-53. doi:10.1016/j.neures.2014.08.015 [doi]
Zhou Y, Peskett TR, Landles C, Warner JB, Sathasivam K, Smith EJ, Chen S, Wetzel R, Lashuel HA, Bates GP, Saibil HR., Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease, Acta Neuropathol Commun. 2021 Apr 14;9(1):70. doi: 10.1186/s40478-021-01172-z.
Martínez-Nieto G, Heljasvaara R, Heikkinen A, Kaski HK, Devarajan R, Rinne O, Henriksson C, Thomson E, von Hertzen C, Miinalainen I, Ruotsalainen H, Pihlajaniemi T, Karppinen SM., Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model, Int J Mol Sci. 2021 Sep 15;22(18):9978. doi: 10.3390/ijms22189978.
Marino, M., Papa, S., Crippa, V., Nardo, G., Peviani, M., Cheroni, C., . . . Bendotti, C. (2015)., Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis, Neurobiology of Aging, 36(1), 492-504. doi:10.1016/j.neurobiolaging.2014.06.026 [doi]
Grimm, C., Chavez, L., Vilardell, M., Farrall, A. L., Tierling, S., Bohm, J. W., . . . Morkel, M. (2013)., DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer., PLoS Genetics, 9(2), e1003250. doi:10.1371/journal.pgen.1003250 [doi]
Mukherjee D, Gonzales BJ, Ashwal-Fluss R, Turm H, Groysman M, Citri A., Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice, Elife. 2021 Mar 16;10:e65228. doi: 10.7554/eLife.65228.
Dupont, C., Loos, F., Kong-A-San, J., & Gribnau, J. (2017)., FGF treatment of host embryos injected with ES cells increases rates of chimaerism., Transgenic Research, 26(2), 237-246. doi:10.1007/s11248-016-9997-6 [doi]
Zhou, Y. S., Ihmoda, I. A., Phelps, R. G., Bellamy, C. O., & Turner, A. N. (2015)., Following specific podocyte injury captopril protects against progressive long term renal damage., F1000research, 4, 172. doi:10.12688/f1000research.4030.1 [doi]
Munoz-Ballester, C., Berthier, A., Viana, R., & Sanz, P. (2016), Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of lafora disease, Biochimica Et Biophysica Acta, 1862(6), 1074-1083. doi:10.1016/j.bbadis.2016.03.008 [doi]
Fagnan A, Bagger FO, Piqué-Borràs MR, Ignacimouttou C, Caulier A, Lopez CK, Robert E, Uzan B, Gelsi-Boyer V, Aid Z, Thirant C, Moll U, Tauchmann S, Kurtovic-Kozaric A, Maciejewski J, Dierks C, Spinelli O, Salmoiraghi S, Pabst T, Shimoda K, Deleuze V, Lapillonne H, Sweeney C, De Mas V, Leite B, Kadri Z, Malinge S, de Botton S, Micol JB, Kile B, Carmichael CL, Iacobucci I, Mullighan CG, Carroll M, Valent P, Bernard OA, Delabesse E, Vyas P, Birnbaum D, Anguita E, Garçon L, Soler E, Schwaller J, Mercher T., Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers, Blood. 2020 Aug 6;136(6):698-714. doi: 10.1182/blood.2019003062.
Rygh, C. B., Lokka, G., Heljasvaara, R., Taxt, T., Pavlin, T., Sormunen, R., . . . Reed, R. K. (2014)., Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice, The Journal of Physiology, 592(Pt 2), 325-336. doi:10.1113/jphysiol.2013.263574 [doi]
Lopez-Gonzalez, I., Viana, R., Sanz, P., & Ferrer, I. (2017)., Inflammation in lafora disease: Evolution with disease progression in laforin and malin knock-out mouse models., Molecular Neurobiology, 54(5), 3119-3130. doi:10.1007/s12035-016-9884-4 [doi]
Marriott, H. M., Gascoyne, K. A., Gowda, R., Geary, I., Nicklin, M. J., Iannelli, F., . . . Dockrell, D. H. (2012)., Interleukin-1beta regulates CXCL8 release and influences disease outcome in response to streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages., Infection and Immunity, 80(3), 1140-1149. doi:10.1128/IAI.05697-11 [doi]
Tortarolo, M., Vallarola, A., Lidonnici, D., Battaglia, E., Gensano, F., Spaltro, G., . . . Bendotti, C. (2015)., Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression, Journal of Neurochemistry, 135(1), 109-124. doi:10.1111/jnc.13154 [doi]
Voikar, V., Kulesskaya, N., Laakso, T., Lauren, J., Strittmatter, S. M., & Airaksinen, M. S. (2013), LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour., Behavioural Brain Research, 238, 69-78. doi:10.1016/j.bbr.2012.10.013 [doi]
Shen, H., Hyrc, K. L., & Goldberg, M. P. (2013), Maintaining energy homeostasis is an essential component of wld(S)-mediated axon protection., Neurobiology of Disease, 59, 69-79. doi:10.1016/j.nbd.2013.07.007 [doi]
Salminen, A. V., Garrett, L., Schormair, B., Rozman, J., Giesert, F., Niedermeier, K. M., . . . Winkelmann, J. (2017)., Meis1: Effects on motor phenotypes and the sensorimotor system in mice., Disease Models & Mechanisms, 10(8), 981-991. doi:10.1242/dmm.030080 [doi]
Kondo, S., Bottos, A., Allegood, J. C., Masson, R., Maurer, F. G., Genoud, C., . . . Hynes, N. E. (2014)., Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development, PloS One, 9(4), e94114. doi:10.1371/journal.pone.0094114 [doi]
Frank, E., Wu, Y., Piyaratna, N., Body, W. J., Snikeris, P., South, T., . . . Huang, X. F. (2012)., Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice, PloS One, 7(8), e42395. doi:10.1371/journal.pone.0042395 [doi]
Pasetto, L., Olivari, D., Nardo, G., Trolese, M. C., Bendotti, C., Piccirillo, R., & Bonetto, V. (2018), Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease., PloS One, 13(5), e0198089. doi:10.1371/journal.pone.0198089 [doi]
Booth, C. A., Brown, J. T., & Randall, A. D. (2014)., Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1., The European Journal of Neuroscience, 39(7), 1074-1090. doi:10.1111/ejn.12549 [doi]
Mizrachi, T., Brill, L., Rabie, M., Nevo, Y., Fellig, Y., Zur, M., . . . Vaknin-Dembinsky, A. (2018)., NMO-IgG and AQP4 peptide can induce aggravation of EAMG and immune-mediated muscle weakness., Journal of Immunology Research, 2018, 5389282. doi:10.1155/2018/5389282 [doi]
Hellsten, K. S., Linden, A. M., & Korpi, E. R. (2015)., Paradoxical widespread c-fos expression induced by a GABA agonist in the forebrain of transgenic mice with ectopic expression of the GABA(A) alpha6 subunit., Neuroscience, 293, 123-135. doi:10.1016/j.neuroscience.2015.02.052 [doi]
Berthier, A., Paya, M., Garcia-Cabrero, A. M., Ballester, M. I., Heredia, M., Serratosa, J. M., . . . Sanz, P. (2015), Pharmacological interventions to ameliorate neuropathological symptoms in a mouse model of lafora disease, Molecular Neurobiology, doi:10.1007/s12035-015-9091-8 [doi]
Berthier, A., Paya, M., Garcia-Cabrero, A. M., Ballester, M. I., Heredia, M., Serratosa, J. M., . . . Sanz, P. (2016), Pharmacological interventions to ameliorate neuropathological symptoms in a mouse model of lafora disease., Molecular Neurobiology, 53(2), 1296-1309. doi:10.1007/s12035-015-9091-8 [doi]
Svarcbahs, Reinis; Jäntti, Maria; Kilpeläinen, Tommi; Julku, Ulrika H; Urvas, Lauri; Kivioja, Saara; Norrbacka, Susanna; MyÜhänen, Timo T;, Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A, Pharmacological research Vol.151, 2019
Mahajan, V. S., Demissie, E., Mattoo, H., Viswanadham, V., Varki, A., Morris, R., & Pillai, S. (2016)., Striking immune phenotypes in gene-targeted mice are driven by a copy-number variant originating from a commercially available C57BL/6 strain., Cell Reports, 15(9), 1901-1909. doi:10.1016/j.celrep.2016.04.080 [doi]
Galliano, E., Potters, J. W., Elgersma, Y., Wisden, W., Kushner, S. A., De Zeeuw, C. I., & Hoebeek, F. E. (2013), Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard nonmotor tasks., The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 33(31), 12599-12618. doi:10.1523/JNEUROSCI.1642-13.2013 [doi]
Montero-Barrera, D., Valderrama-Carvajal, H., Terrazas, C. A., Rojas-Hernandez, S., Ledesma-Soto, Y., Vera-Arias, L., . . . Terrazas, L. I. (2015)., The macrophage galactose-type lectin-1 (MGL1) recognizes taenia crassiceps antigens, triggers intracellular signaling, and is critical for resistance to this infection., BioMed Research International, 2015, 615865. doi:10.1155/2015/615865 [doi]
Kool, M. J., van de Bree, J. E., Bodde, H. E., Elgersma, Y., & van Woerden, G. M. (2016)., The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion., Scientific Reports, 6, 26989. doi:10.1038/srep26989 [doi]
Aumailley, L., Roux-Dalvai, F., Kelly, I., Droit, A., & Lebel, M. (2018)., Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional werner syndrome (wrn) mutant protein., PloS One, 13(3), e0193170. doi:10.1371/journal.pone.0193170 [doi]
Immunology
Kim, Sang-Soo; Harford, Joe B; Moghe, Manish; Slaughter, Tiffani; Doherty, Caroline; Chang, Esther H;, A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma., International journal of cancer Vol.145, 2019
Narra, H. P., Shubitz, L. F., Mandel, M. A., Trinh, H. T., Griffin, K., Buntzman, A. S., . . . Orbach, M. J. (2016)., A coccidioides posadasii CPS1 deletion mutant is avirulent and protects mice from lethal infection., Infection and Immunity, 84(10), 3007-3016. doi:10.1128/IAI.00633-16 [doi]
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Oncology
Meraviglia-Crivelli D, Villanueva H, Menon AP, Zheleva A, Moreno B, Villalba-Esparza M, Pastor F., A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression, Mol Ther Nucleic Acids. 2022 Jul 20;29:413-425. doi: 10.1016/j.omtn.2022.07.017. eCollection 2022 Sep 13.
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Wu Z, Ao Z, Cai H, Li X, Chen B, Tu H, Wang Y, Lu RO, Gu M, Cheng L, Lu X, Guo F., Acoustofluidic assembly of primary tumor-derived organotypic cell clusters for rapid evaluation of cancer immunotherapy., J Nanobiotechnology. 2023 Feb 4;21(1):40. doi: 10.1186/s12951-023-01786-6.
Cervera-Carrascon V, Quixabeira DCA, Santos JM, Havunen R, Milenova I, Verhoeff J, Heiniö C, Zafar S, Garcia-Vallejo JJ, van Beusechem VW, de Gruijl TD, Kalervo A, Sorsa S, Kanerva A, Hemminki A., Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1, Front Immunol. 2021 Jul 23;12:706517. doi: 10.3389/fimmu.2021.706517. eCollection 2021.
Sheinboim D, Parikh S, Manich P, Markus I, Dahan S, Parikh R, Stubbs E, Cohen G, Zemser-Werner V, Bell RE, Ruiz SA, Percik R, Brenner R, Leibou S, Vaknine H, Arad G, Gerber Y, Keinan-Boker L, Shimony T, Bikovski L, Goldstein N, Constantini K, Labes S, Mordechai S, Doron H, Lonescu A, Ziv T, Nizri E, Choshen G, Eldar-Finkelman H, Tabach Y, Helman A, Ben-Eliyahu S, Erez N, Perlson E, Geiger T, Ben-Zvi D, Khaled M, Gepner Y, Levy C., An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination, Cancer Res. 2022 Nov 15;82(22):4164-4178. doi: 10.1158/0008-5472.CAN-22-0237.
Schepelmann M, Kupper N, Gushchina V, Mesteri I, Manhardt T, Moritsch S, Müller C, Piatek K, Salzmann M, Vlasaty A, Eferl R, Kallay E., AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice-A Pilot Study, Int J Mol Sci. 2022 May 9;23(9):5278. doi: 10.3390/ijms23095278.
Kumar S, Mulia GE, Figueiredo ML., Cabozantinib and IL-27 combinatorial therapy for bone-metastatic prostate cancer., Front Mol Biosci. 2023 Sep 28;10:1259336. doi: 10.3389/fmolb.2023.1259336. eCollection 2023.
Vorontsova A, Cooper TJ, Haj-Shomaly J, Benguigui M, Levin S, Manobla B, Menachem R, Timaner M, Raviv Z, Shaked Y., Chemotherapy-induced tumor immunogenicity is mediated in part by megakaryocyte-erythroid progenitors., Oncogene. 2023 Mar;42(10):771-781. doi: 10.1038/s41388-023-02590-0. Epub 2023 Jan 16.
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Jagadeeshan S, Suryamohan K, Shin N, Mathukkada S, Boyko A, Melikhova D, Tsareva A, Yunusova L, Pravdivtseva E, Stupichev D, Shaposhnikov K, Peterson A, Bednyagin L, Shugaev-Mendosa E, Kessler L, Burrows F, Ho AL, Agrawal N, Pearson AT, Izumchenko E, Cole G, Elkabets M, et al., Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma., Oral Oncol. 2024 Jan 13;149:106688. doi: 10.1016/j.oraloncology.2024.106688. [Epub ahead of print]
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Sharp PS, Stylianou M, Arellano LM, Neves JC, Gravagnuolo AM, Dodd A, Barr K, Lozano N, Kisby T, Kostarelos K., Graphene Oxide Nanoscale Platform Enhances the Anti-Cancer Properties of Bortezomib in Glioblastoma Models, Adv Healthc Mater. 2023 Jan;12(3):e2201968. doi: 10.1002/adhm.202201968. Epub 2022 Nov 11.
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Granot-Matok Y, Ezra A, Ramishetti S, Sharma P, Naidu GS, Benhar I, Peer D., Lipid nanoparticles-loaded with toxin mRNA represents a new strategy for the treatment of solid tumors., Theranostics. 2023 Jun 12;13(11):3497-3508. doi: 10.7150/thno.82228. eCollection 2023.
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Salvatori E, Lione L, Compagnone M, Pinto E, Conforti A, Ciliberto G, Aurisicchio L, Palombo F., Neoantigen cancer vaccine augments anti-CTLA-4 efficacy, NPJ Vaccines. 2022 Feb 2;7(1):15. doi: 10.1038/s41541-022-00433-9.
Smith AJ, Thurman RE, Zeng W, Grogan B, Lucas S, Gutierrez G, Heiser RA, Wo SW, Blackmarr A, Peterson S, Gardai SJ., Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity., Front Immunol. 2023 Nov 1;14:1280986. doi: 10.3389/fimmu.2023.1280986. eCollection 2023.
Rivera-Cruz CM, Kumar S, Figueiredo ML., Poly I:C-priming of adipose-derived mesenchymal stromal cells promotes a pro-tumorigenic phenotype in an immunocompetent mouse model of prostate cancer., Front Cell Dev Biol. 2023 Nov 22;11:1145421. doi: 10.3389/fcell.2023.1145421. eCollection 2023.
Freeling JL, Scholl JL, Eikanger M, Knoblich C, Potts RA, Anderson DJ, Rower JE, Farjoo MH, Zhao H, Pillatzki A, Rezvani K., Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model., Cell Death Discov. 2022 Mar 28;8(1):135. doi: 10.1038/s41420-022-00936-3.
Bransi, A., Salgado, O. C., Beffinger, M., Milo, K., Silina, K., Yagita, H., . . . van den Broek, M. (2015)., Rational combination of immunotherapies with clinical efficacy in mice with advanced cancer., Cancer Immunology Research, 3(11), 1279-1288. doi:10.1158/2326-6066.CIR-15-0103-T [doi]
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Barrett, J. A., Cai, H., Miao, J., Khare, P. D., Gonzalez, P., Dalsing-Hernandez, J., . . . Lebel, F. (2018)., Regulated intratumoral expression of IL-12 using a RheoSwitch therapeutic system((R)) (RTS((R))) gene switch as gene therapy for the treatment of glioma., Cancer Gene Therapy, 25(5-6), 106-116. doi:10.1038/s41417-018-0019-0 [doi]
Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jřrgensen C., Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity, Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22.
Willekens C, Laplane L, Dagher T, Benlabiod C, Papadopoulos N, Lacout C, Rameau P, Catelain C, Alfaro A, Edmond V, Signolle N, Marchand V, Droin N, Hoogenboezem R, Schneider RK, Penson A, Abdel-Wahab O, Giraudier S, Pasquier F, Marty C, Plo I, Villeval JL, et al., SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice., Leukemia. 2023 Jun;37(6):1287-1297. doi: 10.1038/s41375-023-01878-0. Epub 2023 Apr 26.
Berger G, Knelson EH, Jimenez-Macias JL, Nowicki MO, Han S, Panagioti E, Lizotte PH, Adu-Berchie K, Stafford A, Dimitrakakis N, Zhou L, Chiocca EA, Mooney DJ, Barbie DA, Lawler SE., STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models, Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2111003119. doi: 10.1073/pnas.2111003119. Epub 2022 Jul 5.
Koch MS, Zdioruk M, Nowicki MO, Griffith AM, Aguilar E, Aguilar LK, Guzik BW, Barone F, Tak PP, Tabatabai G, Lederer JA, Chiocca EA, Lawler S., Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models, J Immunother Cancer. 2022 Jan;10(1):e003368. doi: 10.1136/jitc-2021-003368.
Adewunmi O, Shen Y, Zhang XH, Rosen JM., Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer., Cancer Immunol Res. 2023 Nov 1;11(11):1462-1479. doi: 10.1158/2326-6066.CIR-23-0045.
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Orecchioni S, Falvo P, Talarico G, Mitola G, Bravetti G, Mancuso P, Nicoli P, Bertolini F., Vinorelbine and Intermittent Cyclophosphamide Sensitize an Aggressive Myc-Driven B-Cell Lymphoma to Anti-PD-1 by an Immunological Memory Effective against Tumor Re-Challenge., J Clin Med. 2023 Mar 27;12(7). pii: 2535. doi: 10.3390/jcm12072535.
Osteoporosis
Stephens M, Lopez-Linares K, Aldazabal J, Macias I, Ortuzar N, Bengoetxea H, Bulnes S, Alcorta-Sevillano N, Infante A, Lafuente JV, Rodríguez CI., Murine femur micro-computed tomography and biomechanical datasets for an ovariectomy-induced osteoporosis model., Sci Data. 2021 Sep 15;8(1):240. doi: 10.1038/s41597-021-01012-8.
Surgical
Stephens M, Lopez-Linares K, Aldazabal J, Macias I, Ortuzar N, Bengoetxea H, Bulnes S, Alcorta-Sevillano N, Infante A, Lafuente JV, Rodríguez CI., Murine femur micro-computed tomography and biomechanical datasets for an ovariectomy-induced osteoporosis model., Sci Data. 2021 Sep 15;8(1):240. doi: 10.1038/s41597-021-01012-8.
Kunst RF, de Waart DR, Wolters F, Duijst S, Vogels EW, Bolt I, Verheij J, Beuers U, Oude Elferink RPJ, van de Graaf SFJ. , Systemic ASBT inactivation protects against liver damage in obstructive cholestasis in mice, JHEP Rep. 2022 Aug 27;4(11):100573. doi: 10.1016/j.jhepr.2022.100573.
Toxicology
Smeyne, R. J., Breckenridge, C. B., Beck, M., Jiao, Y., Butt, M. T., Wolf, J. C., . . . Botham, P. A. (2016)., Assessment of the effects of MPTP and paraquat on dopaminergic neurons and microglia in the substantia nigra pars compacta of C57BL/6 mice., PloS One, 11(10), e0164094. doi:10.1371/journal.pone.0164094 [doi]
Fong Z, Lall A, Mullins ND, Santana LF, Hollywood MA, Thornbury KD, Sergeant GP., Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor., Basic Clin Pharmacol Toxicol. 2023 Jul;133(1):29-42. doi: 10.1111/bcpt.13881. Epub 2023 May 13.
Whitemarsh, R. C., Tepp, W. H., Bradshaw, M., Lin, G., Pier, C. L., Scherf, J. M., . . . Pellett, S. (2013)., Characterization of botulinum neurotoxin A subtypes 1 through 5 by investigation of activities in mice, in neuronal cell cultures, and in vitro., Infection and Immunity, 81(10), 3894-3902. doi:10.1128/IAI.00536-13 [doi]
Heiss, Gregor; Ploetz, Evelyn; Voith von Voithenberg, Lena; Viswanathan, Ramya; Glaser, Samson; Schluesche, Peter; Madhira, Sushi; Meisterernst, Michael; Auble, David T; Lamb, Don C;, Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP-DNA dissociation., Nucleic acids research Vol.47, 2019
Kolomansky A, Hiram-Bab S, Ben-Califa N, Liron T, Deshet-Unger N, Mittelman M, Oster HS, Rauner M, Wielockx B, Neumann D, Gabet Y., Erythropoietin Mediated Bone Loss in Mice Is Dose-Dependent and Mostly Irreversible, Int J Mol Sci. 2020 May 27;21(11):3817. doi: 10.3390/ijms21113817.
Springer, Andrea; Heuer, Lea; Janecek-Erfurth, Elisabeth; Beineke, Andreas; Strube, Christina, Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model., Parasitology research Vol.118, 2019
Zhou, H., Malik, M. A., Arab, A., Hill, M. T., & Shikanov, A. (2015), Hydrogel based 3-dimensional (3D) system for toxicity and high-throughput (HTP) analysis for cultured murine ovarian follicles., PloS One, 10(10), e0140205. doi:10.1371/journal.pone.0140205 [doi]
Shukla PK, Rao RG, Meena AS, Giorgianni F, Lee SC, Raju P, Shashikanth N, Shekhar C, Beranova S, Balazs L, Tigyi G, Gosain A, Rao R., Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5, Front Immunol. 2023 Aug 10;14:1174140. doi: 10.3389/fimmu.2023.1174140. eCollection 2023.
Dahl H, Eide DM, Tengs T, Duale N, Kamstra JH, Oughton DH, Olsen AK., Perturbed transcriptional profiles after chronic low dose rate radiation in mice, PLoS One. 2021 Aug 24;16(8):e0256667. doi: 10.1371/journal.pone.0256667. eCollection 2021.
Mariappan N, Zafar I, Robichaud A, Wei CC, Shakil S, Ahmad A, Goymer HM, Abdelsalam A, Kashyap MP, Foote JB, Bae S, Agarwal A, Ahmad S, Athar M, Antony VB, Ahmad A., Pulmonary pathogenesis in a murine model of inhaled arsenical exposure., Arch Toxicol. 2023 Jul;97(7):1847-1858. doi: 10.1007/s00204-023-03503-6. Epub 2023 May 11.
Hoek-van den Hil, E. F., van Schothorst, E. M., van der Stelt, I., Hollman, P. C., Keijer, J., & Rietjens, I. M. (2015), Quercetin tests negative for genotoxicity in transcriptome analyses of liver and small intestine of mice., Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 81, 34-39. doi:10.1016/j.fct.2015.04.005 [doi]
Myhre, O., Eide, D. M., Kleiven, S., Utkilen, H. C., & Hofer, T. (2018), Repeated five-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL/6 mice - lack of adverse cognitive effects., Scientific Reports, 8(1), 2308-018-20327-y. doi:10.1038/s41598-018-20327-y [doi]
Win, S., Than, T. A., Le, B. H., Garcia-Ruiz, C., Fernandez-Checa, J. C., & Kaplowitz, N. (2015)., Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity., Journal of Hepatology, 62(6), 1367-1374. doi:10.1016/j.jhep.2015.01.032 [doi]
Kendziorski, J. A., Kendig, E. L., Gear, R. B., & Belcher, S. M. (2012)., Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17alpha-ethinyl estradiol or the endocrine disrupting chemical bisphenol A, Reproductive Toxicology (Elmsford, N.Y.), 34(1), 22-30. doi:10.1016/j.reprotox.2012.03.001 [doi]
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Deshpande A, Olaitan AO, Mckelvey AM, Rutherford JT, Hurdle JG, The Ferrous Iron Transporter FeoB1 is Essential for Clostridioides difficile Toxin Production and Pathogenesis in Mice, bioRxiv 2022.03.03.482942
Meier, D. T., Entrup, L., Templin, A. T., Hogan, M. F., Mellati, M., Zraika, S., . . . Kahn, S. E. (2016), The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets., Diabetologia, 59(10), 2166-2171. doi:10.1007/s00125-016-4045-x [doi]
Vaccines
Fratzke AP, Gregory AE, van Schaik EJ, Samuel JE., Coxiella burnetii Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model, Front Immunol. 2021 Sep 20;12:754712. doi: 10.3389/fimmu.2021.754712. eCollection 2021.
Aminzadeh A, Tiwari MK, Mamah Mustapha SS, Navarrete SJ, Henriksen AB, Møller IM, Krogfelt KA, Bjerrum MJ, Jørgensen R., Detoxification of toxin A and toxin B by copper ion-catalyzed oxidation in production of a toxoid-based vaccine against Clostridioides difficile, Free Radic Biol Med. 2020 Nov 20;160:433-446. doi: 10.1016/j.freeradbiomed.2020.08.021. Epub 2020 Aug 27.
