BALB/c nude mice
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Imaging
Cohen, G., Lecht, S., Arien-Zakay, H., Ettinger, K., Amsalem, O., Oron-Herman, M., . . . Lazarovici, P. (2012)., Bio-imaging of colorectal cancer models using near infrared labeled epidermal growth factor., PloS One, 7(11), e48803. doi:10.1371/journal.pone.0048803 [doi]
Cohen, G., Lecht, S., Oron-Herman, M., Momic, T., Nissan, A., & Lazarovici, P. (2013)., Near infrared optical visualization of epidermal growth factor receptors levels in COLO205 colorectal cell line, orthotopic tumor in mice and human biopsies., International Journal of Molecular Sciences, 14(7), 14669-14688. doi:10.3390/ijms140714669 [doi]
Trousil, S., Hoppmann, S., Nguyen, Q. D., Kaliszczak, M., Tomasi, G., Iveson, P., . . . Aboagye, E. O. (2014)., Positron emission tomography imaging with 18F-labeled ZHER2:2891 affibody for detection of HER2 expression and pharmacodynamic response to HER2-modulating therapies., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 20(6), 1632-1643. doi:10.1158/1078-0432.CCR-13-2421 [doi]
Alam, I. S., Witney, T. H., Tomasi, G., Carroll, L., Twyman, F. J., Nguyen, Q. D., & Aboagye, E. O. (2014)., Radiolabeled RGD tracer kinetics annotates differential alphavbeta 3 integrin expression linked to cell intrinsic and vessel expression., Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging, 16(4), 558-566. doi:10.1007/s11307-013-0710-3 [doi]
Immunology
Cohen, S., Stemmer, S. M., Zozulya, G., Ochaion, A., Patoka, R., Barer, F., . . . Fishman, P. (2011)., CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver., Journal of Cellular Physiology, 226(9), 2438-2447. doi:10.1002/jcp.22593 [doi]
Komai-Koma, M., Gilchrist, D. S., McKenzie, A. N., Goodyear, C. S., Xu, D., & Liew, F. Y. (2011)., IL-33 activates B1 cells and exacerbates contact sensitivity., Journal of Immunology (Baltimore, Md.: 1950), 186(4), 2584-2591. doi:10.4049/jimmunol.1002103 [doi]
Komai-Koma, M., Brombacher, F., Pushparaj, P. N., Arendse, B., McSharry, C., Alexander, J., . . . Xu, D. (2012)., Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naive mice., Allergy, 67(9), 1118-1126. doi:10.1111/j.1398-9995.2012.02859.x [doi]
Reim, D., Westenfelder, K., Kaiser-Moore, S., Schlautkotter, S., Holzmann, B., & Weighardt, H. (2009)., Role of T cells for cytokine production and outcome in a model of acute septic peritonitis., Shock (Augusta, Ga.), 31(3), 245-250. doi:10.1097/SHK.0b013e31817fd02c [doi]
Tuscano, J. M., Ma, Y., Martin, S. M., Kato, J., & O'Donnell, R. T. (2011)., The Bs20x22 anti-CD20-CD22 bispecific antibody has more lymphomacidal activity than do the parent antibodies alone., Cancer Immunology, Immunotherapy : CII, 60(6), 771-780. doi:10.1007/s00262-011-0978-6 [doi]
Fioravanti, J., Medina-Echeverz, J., Ardaiz, N., Gomar, C., Parra-Guillen, Z. P., Prieto, J., & Berraondo, P. (2012)., The fusion protein of IFN-alpha and apolipoprotein A-I crosses the blood-brain barrier by a saturable transport mechanism., Journal of Immunology (Baltimore, Md.: 1950), 188(8), 3988-3992. doi:10.4049/jimmunol.1101598 [doi]
Solodeev, I., Zahalka, M. A., & Moroz, C. (2014)., The novel C24D synthetic polypeptide inhibits binding of placenta immunosuppressive ferritin to human T cells and elicits anti-breast cancer immunity in vitro and in vivo., Neoplasia (New York, N.Y.), 16(9), 741-750. doi:10.1016/j.neo.2014.08.005 [doi]
Oncology
Cheng, K. W., Wong, C. C., Alston, N., Mackenzie, G. G., Huang, L., Ouyang, N., . . . Rigas, B. (2013)., Aerosol administration of phospho-sulindac inhibits lung tumorigenesis., Molecular Cancer Therapeutics, 12(8), 1417-1428. doi:10.1158/1535-7163.MCT-13-0006-T [doi]
Muscella, A., Vetrugno, C., Migoni, D., Biagioni, F., Fanizzi, F. P., Fornai, F., . . . Marsigliante, S. (2014)., Antitumor activity of [pt(O,O'-acac)(gamma-acac)(DMS)] in mouse xenograft model of breast cancer., Cell Death & Disease, 5, e1014. doi:10.1038/cddis.2013.554 [doi]
Mertens-Talcott, S. U., Noratto, G. D., Li, X., Angel-Morales, G., Bertoldi, M. C., & Safe, S. (2013)., Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of sp transcription factors and microRNA-27a:ZBTB10., Molecular Carcinogenesis, 52(8), 591-602. doi:10.1002/mc.21893 [doi]
Johnson, T. J., Hoti, N., Liu, C., Chowdhury, W. H., Li, Y., Zhang, Y., . . . Rodriguez, R. (2013)., Bicalutamide-activated oncolytic adenovirus for the adjuvant therapy of high-risk prostate cancer., Cancer Gene Therapy, 20(7), 394-402. doi:10.1038/cgt.2013.34 [doi]
Accardo, A., Mansi, R., Salzano, G., Morisco, A., Aurilio, M., Parisi, A., . . . Morelli, G. (2012)., Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells., Journal of Drug Targeting, doi:10.3109/1061186X.2012.741138 [doi]
Tuscano, J. M., Kato, J., Pearson, D., Xiong, C., Newell, L., Ma, Y., . . . O'Donnell, R. T. (2012)., CD22 antigen is broadly expressed on lung cancer cells and is a target for antibody-based therapy., Cancer Research, 72(21), 5556-5565. doi:10.1158/0008-5472.CAN-12-0173 [doi]
Schmid, D., Fay, F., Small, D. M., Jaworski, J., Riley, J. S., Tegazzini, D., . . . Scott, C. J. (2014)., Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine., Molecular Therapy : The Journal of the American Society of Gene Therapy, 22(12), 2083-2092. doi:10.1038/mt.2014.137 [doi]
Tome-Amat, J., Olombrada, M., Ruiz-de-la-Herran, J., Perez-Gomez, E., Andradas, C., Sanchez, C., . . . Lacadena, J. (2015)., Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin alpha-sarcin in nude mice bearing human colorectal cancer xenografts., Springerplus, 4, 168-015-0943-5. eCollection 2015. doi:10.1186/s40064-015-0943-5 [doi]
Gundala, S. R., Mukkavilli, R., Yang, C., Yadav, P., Tandon, V., Vangala, S., . . . Aneja, R. (2014)., Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract., Carcinogenesis, 35(6), 1320-1329. doi:10.1093/carcin/bgu011 [doi]
Chen, C., Constantinou, A., Chester, K. A., Vyas, B., Canis, K., Haslam, S. M., . . . Deonarain, M. P. (2012)., Glycoengineering approach to half-life extension of recombinant biotherapeutics., Bioconjugate Chemistry, 23(8), 1524-1533. doi:10.1021/bc200624a [doi]
Gundala, S. R., Yang, C., Mukkavilli, R., Paranjpe, R., Brahmbhatt, M., Pannu, V., . . . Aneja, R. (2014)., Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis., Toxicology and Applied Pharmacology, 280(1), 86-96. doi:10.1016/j.taap.2014.07.012 [doi]
Cho, E. J., Sun, B., Doh, K. O., Wilson, E. M., Torregrosa-Allen, S., Elzey, B. D., & Yeo, Y. (2015)., Intraperitoneal delivery of platinum with in-situ crosslinkable hyaluronic acid gel for local therapy of ovarian cancer., Biomaterials, 37, 312-319. doi:10.1016/j.biomaterials.2014.10.039 [doi]
Ganapathy, S., Xiao, S., Seo, S. J., Lall, R., Yang, M., Xu, T., . . . Yuan, Z. M. (2014)., Low-dose arsenic induces chemotherapy protection via p53/NF-kappaB-mediated metabolic regulation., Oncogene, 33(11), 1359-1366. doi:10.1038/onc.2013.81 [doi]
Banerjee, N., Kim, H., Krenek, K., Talcott, S. T., & Mertens-Talcott, S. U. (2015)., Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: Role of the PI3K/AKT pathway and associated microRNAs., Nutrition Research (New York, N.Y.), 35(8), 744-751. doi:10.1016/j.nutres.2015.06.002 [doi]
Bofill-De Ros, X., Gironella, M., & Fillat, C. (2014)., miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity., Molecular Therapy : The Journal of the American Society of Gene Therapy, 22(9), 1665-1677. doi:10.1038/mt.2014.98 [doi]
Wong, H. H., Jiang, G., Gangeswaran, R., Wang, P., Wang, J., Yuan, M., . . . Wang, Y. (2012)., Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11., Molecular Therapy : The Journal of the American Society of Gene Therapy, 20(2), 306-316. doi:10.1038/mt.2011.242 [doi]
Mu, Z., Ma, C. M., Chen, X., Cvetkovic, D., Pollack, A., & Chen, L. (2012)., MR-guided pulsed high intensity focused ultrasound enhancement of docetaxel combined with radiotherapy for prostate cancer treatment., Physics in Medicine and Biology, 57(2), 535-545. doi:10.1088/0031-9155/57/2/535 [doi]
Wang, C. Z., Zhang, Z., Anderson, S., & Yuan, C. S. (2014)., Natural products and chemotherapeutic agents on cancer: Prevention vs. treatment., The American Journal of Chinese Medicine, 42(6), 1555-1558. doi:10.1142/S0192415X1420002X [doi]
Accardo, A., Salsano, G., Morisco, A., Aurilio, M., Parisi, A., Maione, F., . . . Morelli, G. (2012)., Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent., International Journal of Nanomedicine, 7, 2007-2017. doi:10.2147/IJN.S29242 [doi]
Gundala, S. R., Yang, C., Lakshminarayana, N., Asif, G., Gupta, M. V., Shamsi, S., & Aneja, R. (2013)., Polar biophenolics in sweet potato greens extract synergize to inhibit prostate cancer cell proliferation and in vivo tumor growth., Carcinogenesis, 34(9), 2039-2049. doi:10.1093/carcin/bgt141 [doi]
Wang, C. Z., Zhang, Z., Wan, J. Y., Zhang, C. F., Anderson, S., He, X., . . . Yuan, C. S. (2015)., Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer., Nutrients, 7(2), 799-814. doi:10.3390/nu7020799 [doi]
Xu, W., Liu, L., Brown, N. J., Christian, S., & Hornby, D. (2012)., Quantum dot-conjugated anti-GRP78 scFv inhibits cancer growth in mice., Molecules (Basel, Switzerland), 17(1), 796-808. doi:10.3390/molecules17010796 [doi]
Saelen, M. G., Ree, A. H., Kristian, A., Fleten, K. G., Furre, T., Hektoen, H. H., & Flatmark, K. (2012)., Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma., Radiation Oncology (London, England), 7, 165-717X-7-165. doi:10.1186/1748-717X-7-165 [doi]
Pozzi, V., Sartini, D., Morganti, S., Giuliante, R., Di Ruscio, G., Santarelli, A., . . . Emanuelli, M. (2013)., RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells., PloS One, 8(8), e71272. doi:10.1371/journal.pone.0071272 [doi]
Fokas, E., Prevo, R., Pollard, J. R., Reaper, P. M., Charlton, P. A., Cornelissen, B., . . . Brunner, T. B. (2012)., Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation., Cell Death & Disease, 3, e441. doi:10.1038/cddis.2012.181 [doi]
Jin, H. R., Zhao, J., Zhang, Z., Liao, Y., Wang, C. Z., Huang, W. H., . . . Du, W. (2012)., The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress., Cell Death & Disease, 3, e376. doi:10.1038/cddis.2012.122 [doi]
Solodeev, I., Zahalka, M. A., & Moroz, C. (2014)., The novel C24D synthetic polypeptide inhibits binding of placenta immunosuppressive ferritin to human T cells and elicits anti-breast cancer immunity in vitro and in vivo., Neoplasia (New York, N.Y.), 16(9), 741-750. doi:10.1016/j.neo.2014.08.005 [doi]
Zhou, H., Ekmekcioglu, S., Marks, J. W., Mohamedali, K. A., Asrani, K., Phillips, K. K., . . . Rosenblum, M. G. (2013)., The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment., The Journal of Investigative Dermatology, 133(4), 1052-1062. doi:10.1038/jid.2012.402 [doi]
Transplantation
Sheehy, E. J., Vinardell, T., Buckley, C. T., & Kelly, D. J. (2013)., Engineering osteochondral constructs through spatial regulation of endochondral ossification., Acta Biomaterialia, 9(3), 5484-5492. doi:10.1016/j.actbio.2012.11.008 [doi]
Ophir, E., Eidelstein, Y., Afik, R., Bachar-Lustig, E., & Reisner, Y. (2010)., Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells., Blood, 115(10), 2095-2104. doi:10.1182/blood-2009-10-248716 [doi]
Cunniffe, G. M., Vinardell, T., Murphy, J. M., Thompson, E. M., Matsiko, A., O'Brien, F. J., & Kelly, D. J. (2015)., Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing., Acta Biomaterialia, 23, 82-90. doi:10.1016/j.actbio.2015.05.031 [doi]
Ra, J. C., Shin, I. S., Kim, S. H., Kang, S. K., Kang, B. C., Lee, H. Y., . . . Kwon, E. (2011)., Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans., Stem Cells and Development, 20(8), 1297-1308. doi:10.1089/scd.2010.0466 [doi]
Tumor growth
Yang, P., Guo, L., Duan, Z. J., Tepper, C. G., Xue, L., Chen, X., . . . Chen, H. W. (2012)., Histone methyltransferase NSD2/MMSET mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop., Molecular and Cellular Biology, 32(15), 3121-3131. doi:10.1128/MCB.00204-12 [doi]
Pozzi, V., Sartini, D., Rocchetti, R., Santarelli, A., Rubini, C., Morganti, S., . . . Emanuelli, M. (2015)., Identification and characterization of cancer stem cells from head and neck squamous cell carcinoma cell lines., Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 36(2), 784-798. doi:10.1159/000430138 [doi]
Chen, D., Forootan, S. S., Gosney, J. R., Forootan, F. S., & Ke, Y. (2014)., Increased expression of Id1 and Id3 promotes tumorigenicity by enhancing angiogenesis and suppressing apoptosis in small cell lung cancer., Genes & Cancer, 5(5-6), 212-225.
Lu, H., Hu, L., Yu, L., Wang, X., Urvalek, A. M., Li, T., . . . Zhao, J. (2014)., KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer., Oncogene, 33(22), 2909-2917. doi:10.1038/onc.2013.247 [doi]
Holen, I., Whitworth, J., Nutter, F., Evans, A., Brown, H. K., Lefley, D. V., . . . Ottewell, P. D. (2012)., Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo., Breast Cancer Research : BCR, 14(3), R86. doi:bcr3201 [pii]
Qi, X., Yin, N., Ma, S., Lepp, A., Tang, J., Jing, W., . . . Chen, G. (2015)., p38gamma MAPK is a therapeutic target for triple-negative breast cancer by stimulation of cancer stem-like cell expansion., Stem Cells (Dayton, Ohio), 33(9), 2738-2747. doi:10.1002/stem.2068 [doi]
Sabag, A. D., Bode, J., Fink, D., Kigel, B., Kugler, W., & Neufeld, G. (2012)., Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain., PloS One, 7(8), e42912. doi:10.1371/journal.pone.0042912 [doi]
Lascano, V., Zabalegui, L. F., Cameron, K., Guadagnoli, M., Jansen, M., Burggraaf, M., . . . Hahne, M. (2012)., The TNF family member APRIL promotes colorectal tumorigenesis., Cell Death and Differentiation, 19(11), 1826-1835. doi:10.1038/cdd.2012.68 [doi]
Cathcart, M. C., Gately, K., Cummins, R., Drakeford, C., Kay, E. W., O'Byrne, K. J., & Pidgeon, G. P. (2014)., Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer., Biochimica Et Biophysica Acta, 1842(5), 747-755. doi:10.1016/j.bbadis.2014.01.011 [doi]
Grimmig, T., Matthes, N., Hoeland, K., Tripathi, S., Chandraker, A., Grimm, M., . . . Gasser, M. (2015)., TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer., International Journal of Oncology, 47(3), 857-866. doi:10.3892/ijo.2015.3069 [doi]
