B-NDG knockout mice
Related publications
Aging
Jiang R, Gao J, Shen J, Zhu X, Wang H, Feng S, Huang C, Shen H, Liu H., Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation, Front Aging Neurosci. 2020 Oct 7;12:570116. doi: 10.3389/fnagi.2020.570116. eCollection 2020.
Wu, Yating; Zhu, Jianbo; Liu, Haifeng; Liu, Hailiang, Licochalcone A improves the cognitive ability of mice by regulating T- and B-cell proliferation, Aging. 2021.
Chemoresistance
Wang, Qiongyao; Zeng, Fanrui; Sun, Yanqin; Qiu, Qianqian; Zhang, Jian; Huang, Weimei; Huang, Jie; Huang, Xiaomin; Guo, Linlang., Etk Interaction with PFKFB4 Modulates Chemoresistance of Small-cell Lung Cancer by Regulating Autophagy., Clinical cancer research : an official journal of the American Association for Cancer Research Vol.24, 2018
Chen, Zhan-Hong; Qi, Jing-Jing; Wu, Qi-Nian; Lu, Jia-Huan; Liu, Ze-Xian; Wang, Yun; Hu, Pei-Shan; Li, Ting; Lin, Jin-Fei; Wu, Xiang-Yuan; Miao, Lei; Zeng, Zhao-Lei; Xie, Dan; Ju, Huai-Qiang; Xu, Rui-Hua; Wang, Feng., Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer., Journal of experimental & clinical cancer research : CR Vol.38, 2019
Xia, Jiliang; He, Yanjuan; Meng, Bin; Chen, Shilian; Zhang, Jingyu; Wu, Xuan; Zhu, Yinghong; Shen, Yi; Feng, Xiangling; Guan, Yongjun; Kuang, Chunmei; Guo, Jiaojiao; Lei, Qian; Wu, Yangbowen; An, Gang; Li, Guancheng; Qiu, Lugui; Zhan, Fenghuang; Zhou, Wen., NEK2 induces autophagy-mediated bortezomib resistance by stabilizing Beclin-1 in multiple myeloma., Molecular oncology Vol.14, 2020
General studies
Wildt, Sheryl June; Naden, Jamie; Xiang, Jie; Shen, Yuelei; Zhang, Meiling, Abstract 2941: Development and characterization of the ultra-immunodeficient NOD.CB17-Prkdcscid IL2rgtm1/Bcgen (B-NDG) mouse model, Cancer Research. 2021.
Zheng, Chaoyue; Lu, Zhen; Wu, Haisi; Cui, Lulu; Bi, Jiacheng; Wan, Xiaochun, Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells, International Immunopharmacology. 2021.
Jifeng Zhang, Lei Zhao, Jing Wang, Zhihua Cheng, Mengyao Sun et al., Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis, Arthritis Rheumatol, 72: 303-315.
Immunotherapy
Mei, Heng; Li, Chenggong; Jiang, Huiwen; Zhao, Xinying; Huang, Zhiping; Jin, Dan; Guo, Tao; Kou, Haiming; Liu, Lin; Tang, Lu; Yin, Ping; Wang, Zhihui; Ai, Lisha; Ke, Sha; Xia, Yimeng; Deng, Jun; Chen, Lei; Cai, Li; Sun, Chunyan; Xia, Linghui; Hua, Gaoquan; Hu, Yu, A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma, Journal of Hematology & Oncology. 2021.
Vigant F, He Q, Zhang W, et al., Abstract 117:Rapid point-of-care subcutaneous CAR-T from blood draw to injection in 4 hours with modified LV encoding CARs and synthetic driver elements enables efficient CAR-T expansion and tumor regression, Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0117
Amit K. Chaudhary, Jiadong Shi, Wenyan Cai, Bo Wang, Mohd S. Zaman, Cai Huang, Jun Lin, Steven Z. Kan, Joe Zhou, Jianbo Dong, Yue Liu., Abstract LB067: Development of a novel bispecific antibody targeting PD-L1 and CD55 for cancer therapy, Cancer Res 2021;81(13_Suppl):Abstract nr LB067.
Zhao, Bixing; Wang, Yingchao; Tan, Xionghong; Zheng, Xiaoyuan; Wang, Fei; Ke, Kun; Zhang, Cuilin; Liao, Naishun; Dang, Yuan; Shi, Yingjun; Zheng, Youshi; Gao, Yunzhen; Li, Qin; Liu, Xiaolong; Liu, Jingfeng., An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy., Theranostics Vol.9, 2019
Cao, Zhijie; Kon, Ning; Liu, Yajing; Xu, Wenbin; Wen, Jia; Yao, Han; Zhang, Mi; Wu, Zhen; Yan, Xiaojun; Zhu, Wei-Guo; Gu, Wei; Wang, Donglai, An unexpected role for p53 in regulating cancer cell intrinsic PD-1 by acetylation, Science Advances. 2021.
Ao, Xiang; Yang, Yu; Li, Weiqiang; Tan, Yan; Guo, Wei; Ao, Luoquan; He, Xiao; Wu, Xiaofeng; Xia, Jianchuan; Xu, Xiang; Guo, Jianxin., Anti-ÎąFR CAR-engineered NK-92 Cells Display Potent Cytotoxicity Against ÎąFR-positive Ovarian Cancer, Journal of immunotherapy (Hagerstown, Md. : 1997) Vol.42, 2019
Cai, Wenyan; Dong, Jianbo; Gallolu Kankanamalage, Sachith; Titong, Allison; Shi, Jiadong; Jia, Zhejun; Wang, Bo; Huang, Cai; Zhang, Jing; Lin, Jun; Kan, Steven Z; Han, Shuhua; Zhou, Joe; Liu, Yue, Biological activity validation of a computationally designed Rituximab/CD3 T cell engager targeting CD20+ cancers with multiple mechanisms of action, Antibody Therapeutics. 2021.
Li, Yangyang; Zhang, Yu; Cao, Guoshuai; Zheng, Xiaodong; Sun, Cheng; Wei, Haiming; Tian, Zhigang; Xiao, Weihua; Sun, Rui; Sun, Haoyu, Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors, Journal of Hematology & Oncology. 2021.
Yuan X, Liu Y, Li G, Lan Z, Ma M, Li H, Kong J, et al., Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 6B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection, Cancer Immunol Res . 2019. Sep;7(9):1440-1456.
Wang, Ying; Zhong, Kailun; Ke, Jun; Chen, Xi; Chen, Yi; Shu, Wangyun; Chen, Chunhuan; Hu, Shan; Sun, Xiaoke; Huang, Haibin; Luo, Chong; Liu, Lifang; Yang, Jiaming; Zhang, Yongke; Zhi, Huijun, Combined 4-1BB and ICOS co-stimulation improves anti-tumor efficacy and persistence of dual anti-CD19/CD20 chimeric antigen receptor T cells, Cytotherapy. 2021.
He, Huan; Liao, Qibin; Zhao, Chen; Zhu, Cuisong; Feng, Meiqi; Liu, Zhuoqun; Jiang, Lang; Zhang, Linxia; Ding, Xiangqing; Yuan, Min; Zhang, Xiaoyan; Xu, Jianqing, Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy, Journal for Immunotherapy of Cancer. 2021.
Sun, Bin; Yang, Dong; Dai, Hongjiu; Liu, Xiuyun; Jia, Ru; Cui, Xiaoyue; Li, Wenxuan; Cai, Changchun; Xu, Jianming; Zhao, Xudong., Eradication of Hepatocellular Carcinoma by NKG2D-Based CAR-T Cells., Cancer immunology research Vol.7, 2019
Chenfei Zhou, Yanmei Zhang, Ruiming Yan, Lei Huang, Andrew L. Mellor, Yang Yang, et al., Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment, Cell Death & Differentiation volume 28, pages 715â729 (2021)
Wang, Jingbo; Shao, Lijuan; Wu, Liujing; Ma, Wei; Zheng, Yuanyuan; Hu, Chaofeng; Li, Furong., Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immune-response in a humanized mice model., Thoracic cancer Vol.7, 2020
Cheng H, Wang L, Yang B, Li D, Wang X, Liu X, Tian N, Huang Q, Feng R, Wang Z, Liang R, Dai SM, Lv L, Wu J, Zang YS, Li B., Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10(+) FOXP3(+)-Induced Regulatory T Cells, J Immunol. 2020 Sep 15;205(6):1497-1502. doi: 10.4049/jimmunol.2000136. Epub 2020 Aug 19.
Qiao, Tianyun; Xiong, Yanlu; Feng, Yangbo; Guo, Wenwen; Zhou, Yongsheng; Zhao, Jinbo; Jiang, Tao; Shi, Changhong; Han, Yong, Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model, Frontiers in Oncology. 2021.
Dai, Kai; Huang, Yabing; Chen, Zubing; Sun, Xiaomei; Yang, Lihua; Jiang, Yingan., Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model., European journal of immunology Vol.48, 2018
Pan LN, Ma YF, Li Z, Hu JA, Xu ZH., KRAS G12V mutation upregulates PD-L1 expression via TGF-β/EMT signaling pathway in human non-small cell lung cancer, Cell Biol Int. 2020 Dec 15. doi: 10.1002/cbin.11524. Online ahead of print.
Hu Z, Zheng X, Jiao D, Zhou Y, Sun R, Wang B, Tian Z, Wei H., LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer, Mol Ther Oncolytics. 2020 Apr 21;17:361-370. doi: 10.1016/j.omto.2020.04.008. eCollection 2020 Jun 26.
Pesini C, Hidalgo S, Arias MA, Santiago L, Calvo C, Ocariz-Díez M, Isla D, Lanuza PM, Agustín MJ, Galvez EM, Ramírez-Labrada A, Pardo J., PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells, Oncoimmunology. 2022 Jul 6;11(1):2096359.
Lv C, Chen S, Hu F, Huang D, Wang T, Du J, Wang J, Wu H., Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo, Cell Mol Immunol. 2020 Jun 15. doi: 10.1038/s41423-020-0429-4. Online ahead of print.
Zhang, Yajing; Yu, Xiaohong; Liu, Qiuping; Gong, Haiping; Chen, An-an; Zheng, Hongjun; Zhong, Shi; Li, Yi, SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy, Molecular Cancer Therapeutics. 2021.
Chen, Ruifeng; Wang, Meng; Liu, Qiang; Wu, Jiajing; Huang, Weijing; Li, Xuejiao; Du, Baohua; Xu, Qilong; Duan, Jingjing; Jiao, Shunchang; Lee, Hyun Soo; Jung, Nam-Chul; Lee, Jun-Ho; Wang, Yu; Wang, Youchun., Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice, Cancer letters Vol.469, 2020
Yang, Dong; Sun, Bin; Dai, Hongjiu; Li, Wenxuan; Shi, Lan; Zhang, Peixian; Li, Shirong; Zhao, Xudong., T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells., Journal for immunotherapy of cancer Vol.7, 2019
Liu J, Xavy S, Mihardja S, Chen S, Sompalli K, Feng D, Choi T, Agoram B, Majeti R, Weissman IL, Volkmer JP., Targeting macrophage checkpoint inhibitor SIRPÎą for anticancer therapy, JCI Insight. 2020 Jun 18;5(12):e134728. doi: 10.1172/jci.insight.134728.
Yang, Pengxiang; Cao, Xingjian; Cai, Huilong; Feng, Panfeng; Chen, Xiang; Zhu, Yihua; Yang, Yue; An, Weiwei; Yang, Yumin; Jie, Jing, The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth, Cellular Immunology. 2021.
Li, Guangchao; Zhang, Qing; Liu, Zhi; Shen, Huijuan; Zhu, Yangmin; Zhou, Zhao; Ding, Wen; Han, Siqi; Zhou, Jie; Ou, Ruiming; Luo, Min; Liu, Shuang, TriBAFF-CAR-T cells eliminate B-cell malignancies with BAFFR-expression and CD19 antigen loss, Cancer Cell International. 2021.
Li R, Gan S, Zhang X, Cuff P, Wang Z, Broudy T., Use of luminescent xenograft and 3D In vitro tumor models in pharmacology studies of chimeric antigen receptor-T (CAR-T) cells, [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr A016.
Infectious disease
Mu-Sheng Zeng, li yan, Hua Zhang, Xiao-Dong Dong, et al., R9AP is a functional receptor for Epstein-Barr virus infection in both epithelial cells and B cells, PrePrint. Research Square [https://doi.org/10.21203/rs.3.rs-113641/v1]
Oncology
Tu C, Du Z, Zhang H, Feng Y, Qi Y, Zheng Y, Liu J, Wang J., Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells., Theranostics 2021; 11(5):2364-2380. doi:10.7150/thno.47996.
He, Yanjuan; Jiang, Duanfeng; Zhang, Kaixuan; Zhu, Yinghong; Zhang, Jingyu; Wu, Xuan; Xia, Jiliang; Zhu, Yan; Zou, Lang; Hu, Jian; Cui, Yajuan; Zhou, Wen; Chen, Fangping, Chidamide, a subtype-selective histone deacetylase inhibitor, enhances Bortezomib effects in multiple myeloma therapy, Journal of Cancer. 2021.
Jiang, Duanfeng; Zhang, Kaixuan; Zhu, Yinghong; Zhu, Yan; Zou, Lang; Hu, Jian; Cui, Yajuan; Zhou, Wen; Chen, Fangping; He, Yanjuan, Chidamide-Induced Accumulation of Reactive Oxygen Species Increases Lenalidomide Sensitivity Against Multiple Myeloma Cells, OncoTargets and therapy. 2021.
Huang, Weimei; Yang, Yunchu; Wu, Jingfang; Niu, Yuchun; Yao, Yao; Zhang, Jian; Huang, Xiaoxian; Liang, Shumei; Chen, Rui; Chen, Size; Guo, Linlang., Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-β signalling, Cell death and differentiation Vol.27, 2020
Chen, Wancheng; Wang, Xuefei; Zhao, Bingxia; Zhang, Rongjun; Xie, Zhen; He, Yi; Chen, Ali; Xie, Xiaofang; Yao, Kaitai; Zhong, Mei; Yuan, Miaomiao., CuS-MnS2 nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis., Nanoscale Vol.11, 2019
Han, Siqi; Li, Guangchao; Jia, Meng; Zhao, Yulu; He, Chenglong; Huang, Mengxi; Jiang, Longwei; Wu, Meijuan; Yang, Jiahe; Ji, Xiaoqin; Liu, Xiaobei; Chen, Cheng; Chu, Xiaoyuan, Delivery of Anti-miRNA-221 for Colorectal Carcinoma Therapy Using Modified Cord Blood Mesenchymal Stem Cells-Derived Exosomes, Frontiers in Molecular Biosciences. 2021.
Mahati, Shaya; Fu, Xiangjun; Ma, Xuexian; Zhang, Hua; Xiao, Lei, Delivery of miR-26a Using an Exosomes-Based Nanosystem Inhibited Proliferation of Hepatocellular Carcinoma, Frontiers in Molecular Biosciences. 2021.
Xiao, Xinhua; Li, Huiliang; Jin, Huizi; Jin, Jin; Yu, Miao; Ma, Chunmin; Tong, Yin; Zhou, Li; Lei, Hu; Xu, Hanzhang; Zhang, Weidong; Liu, Wei; Wu, Yingli., Identification of 11(13)-dehydroivaxillin as a potent therapeutic agent against non-Hodgkins lymphoma., Cell death & disease Vol.8, 2017
Chen, Tianyue; Ding, Xiangqing; Liao, Qibin; Gao, Nan; Chen, Ye; Zhao, Chen; Zhang, Xiaoyan; Xu, Jianqing, IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy, Journal for Immunotherapy of Cancer. 2021.
Wang, Dan; Chen, Yao; Fang, Houshun; Zheng, Liang; Li, Ying; Yang, Fan; Xu, Yan; Du, Lijuan; Zhou, Bin-Bing S; Li, Hui., Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil., Journal of cellular and molecular medicine Vol.22, 2018
Wang, Shuyu; Zeng, Fanrui; Liang, Shumei; Wang, Qiuping; Wen, Yang; Wang, Qiongyao; Zhang, Jiexia; Li, Man; Fang, Shun; Wei, Ting; Li, Minglun; Manapov, Farkhad; Zhang, Jian; Guo, Linlang, lncRNA Linc00173 modulates glucosemetabolism and multidrug chemoresistancein SCLC: Potential molecular panel for targeted therapy, Molecular Therapy. 2021.
Sun, Yu; Sun, Ye; Yan, Kun; Li, Zhuxuan; Xu, Cheng; Geng, Yibo; Pan, Changcun; Chen, Xin; Zhang, Liwei; Xi, Qiaoran., Potent anti-tumor efficacy of palbociclib in treatment-naĂŻve H3.3K27M-mutant diffuse intrinsic pontine glioma, EBioMedicine Vol.43, 2019
Gong, Jianhua; Guo, Feihu; Cheng, Weihua; Fan, Hongqiang; Miao, Qingfang; Yang, Jigang., Preliminary biological evaluation of 123I-labelled anti-CD30-LDM in CD30-positive lymphomas murine models., Artificial cells, nanomedicine, and biotechnology Vol.48, 2020
Lei, Hu; Tu, Yaoyao; Yang, Li; Jin, Jin; Luo, Hao; Xu, Hanzhang; Kang, Jingwu; Zhou, Li; Wu, Yingli., Quinacrine Depletes BCR-ABL and Suppresses Ph-Positive Leukemia Cells., Cancer investigation Vol.37, 2019
Lei, Hu; Xu, Han-Zhang; Shan, Hui-Zhuang; Liu, Meng; Lu, Ying; Fang, Zhi-Xiao; Jin, Jin; Jing, Bo; Xiao, Xin-Hua; Gao, Shen-Meng; Gao, Feng-Hou; Xia, Li; Yang, Li; Liu, Li-Gen; Wang, Wei-Wei; Liu, Chuan-Xu; Tong, Yin; Wu, Yun-Zhao; Zheng, Jun-Ke; Chen, Guo-Qiang; Zhou, Li; Wu, Ying-Li, Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia, Nature Communications. 2021.
Qiao, Xinan; Ma, Jun; Knight, Tristan; Su, Yongwei; Edwards, Holly; Polin, Lisa; Li, Jing; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn; Wang, Jian; Lin, Hai; Wang, Yue; Wang, Liping; Wang, Guan; Taub, Jeffrey W.; Ge, Yubin, The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML, Blood Cancer Journal. 2021.
Chen, Hua-Dong; Huang, Chen-Song; Xu, Qiong-Cong; Li, Fuxi; Huang, Xi-Tai; Wang, Jie-Qin; Li, Shi-Jin; Zhao, Wei; Yin, Xiao-Yu., Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma., International journal of biological sciences Vol.16, 2020
Wu, Rihui; Mei, Xueting; Ye, Yibiao; Xue, Ting; Wang, Jiasheng; Sun, Wenjia; Lin, Caixia; Xue, Ruoxue; Zhang, Jiabao; Xu, Donghui., Zn(II)-curcumin solid dispersion impairs hepatocellular carcinoma growth and enhances chemotherapy by modulating gut microbiota-mediated zinc homeostasis., Pharmacological research Vol.150, 2019
Stem cells
Dong Y, Bai J, Zhang Y, Zhou Y, Pan X, Li X, Zhou Q, Chen Y, Lai M, et al., Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals, J Leukoc Biol . 2020 Dec;108(6):1711-1725.
Gu, Yang; Wang, Yanying; He, Luyun; Zhang, Jiahang; Zhu, Xiaoxiao; Liu, Nian; Wang, Jianyi; Lu, Tiankun; He, Lei; Tian, Yong; Fan, Zusen, Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Molecular Cancer. 2021.
Jingbo Wang, Lijuan Shao, Liujing Wu, Wei Ma, et al., Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immuneâresponse in a humanized mice model, Thorac Cancer, 11: 1603-1612.
Wen-Bing Ma, Xiao-Han Wang, Chang-Yan Li, Huan-Huan Tian, Jie Zhang, Jun-Jie Bi, et al., GPS2 promotes erythroid differentiation by control of the stability of EKLF protein, Blood (2020) 135 (25): 2302â2315.
Guo, Rongqun; Hu, Fangxiao; Weng, Qitong; Lv, Cui; Wu, Hongling; Liu, Lijuan; Li, Zongcheng; Zeng, Yang; Bai, Zhijie; Zhang, Mengyun; Liu, Yuting; Liu, Xiaofei; Xia, Chengxiang; Wang, Tongjie; Zhou, Peiqing; Wang, Kaitao; Dong, Yong; Luo, Yuxuan; Zhang, Xiangzhong; Guan, Yuxian; Geng, Yang; Du, Juan; Li, Yangqiu; Lan, Yu; Chen, Jiekai; Liu, Bing; Wang, Jinyong., Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors., Cell research Vol.30, 2020
Yuxin Tan, Lu Ding, Can Can, Fuling Zhou, Hematopoietic Reconstitution of Human Umbilical Cord Mesenchymal Stem Cells after Leukemia Chemotherapy: Effectiveness and Safety, Blood (2021) 138 (Supplement 1): 2171.
Wang J, Li Y, Wang P, Han G, Zhang T, Chang J, Yin R, Shan Y, et al., Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis, Cell Stem Cell. 2020 Jul 2;27(1):81-97.e8.
Zhan, Yonghao; Chen, Zhicong; He, Shiming; Gong, Yanqing; He, Anbang; Li, Yifan; Zhang, Lianghao; Zhang, Xuepei; Fang, Dong; Li, Xuesong; Zhou, Liqun., Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2., Molecular cancer Vol.19, 2020
Yong Chen, Le Han, Shanshan Zhao et al., Long-term Reconstruction of Human Airway Epithelium-like Structure in Vivo with hESCs-derived organoid cells, bioRxiv 2020.07.18.209940
Wang Y, Huang J, Gong L, Yu D, An C, Bunpetch V, Dai J, Huang H, Zou X, Ouyang H, Liu H., The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I, iScience. 2019 May 31;15:66-78. doi: 10.1016/j.isci.2019.04.011. Epub 2019 Apr 11.
Wang T, Cui Lv, Hu F, Liu L, Wang J., Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells, Blood Science: July 2020 - Volume 2 - Issue 3 - p 79-88
doi: 10.1097/BS9.0000000000000049
Tumor biology
Rodriguez-Meira A, Norfo R, Wen S, Chédeville AL, Rahman H, O'Sullivan J, Wang G, Louka E, Kretzschmar WW, Paterson A, Brierley C, Martin JE, Demeule C, Bashton M, Sousos N, Moralli D, Subha Meem L, Carrelha J, Wu B, Hamblin A, Guermouche H, Pasquier F, Marzac C, Girodon F, Vainchenker W, Drummond M, Harrison C, Chapman JR, Plo I, Jacobsen SEW, Psaila B, Thongjuea S, Antony-Debré I, Mead AJ., Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution, Nat Genet. 2023 Sep;55(9):1531-1541. doi: 10.1038/s41588-023-01480-1.
Tumor cell growth
Justin Snider;
Derrik Germain;
Lauren Kucharczyk;
Anita Zaitouna;
Erin Trachet;
Scott Wise, Abstract 41: Subcutaneous growth and immune cell profiling of BT-474 human breast carcinoma in four strains of triple immunodeficient mice, Cancer Res (2023) 83 (7_Supplement): 41.
Tumor growth
Guan L, Zou Q, Liu Q, Chen S., [Comparison of B-NDG and BALB/c mouse models bearing patient-derived xenografts of esophageal squamous cell carcinoma], Nan Fang Yi Ke Da Xue Xue Bao. 2020 Aug 30;40(8):1200-1206. doi: 10.12122/j.issn.1673-4254.2020.08.19.
Zhang, Danfeng; Huang, Jingcao; Wang, Fangfang; Ding, Hong; Cui, Yushan; Yang, Yan; Xu, Juan; Luo, Hongmei; Gao, Yuhan; Pan, Ling; Wu, Yu; Gong, Yuping; Xie, Liping; Liu, Zhigang; Qu, Ying; Zhang, Li; Liu, Weiping; Zhang, Wenyan; Zhao, Sha; Yi, Qing; Niu, Ting; Zheng, Yuhuan, BMI1 regulates multiple myeloma-associated macrophages pro-myeloma functions, Cell Death & Disease. 2021.
Zhou, Chenfei; Wei, Wenfei; Ma, Jing; Yang, Yang; Liang, Luojiao; Zhang, Yanmei; Wang, Zici; Chen, Xiaojing; Huang, Lei; Wang, Wei; Wu, Sha, Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels, Molecular Therapy. 2021.
Li, Yifan; Gong, Yanqing; Ning, Xianghui; Peng, Ding; Liu, Libo; He, Shiming; Gong, Kan; Zhang, Cuijian; Li, Xuesong; Zhou, Liqun., Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis., Journal of experimental & clinical cancer research : CR Vol.37, 2018
Chen, Zhanjun; Xiang, Leyang; Hu, Zhigang; Ou, Huohui; Liu, Xiao; Yu, Lili; Chen, Wancheng; Jiang, Lei; Yu, Qiangfeng; Fang, Yinghao; Xu, Yuyan; Liu, Qin; Huang, Yu; Li, Xianghong; Yang, Dinghua, Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription, American Journal of Cancer Research. 2021.
Gao, Xiaomei; Dai, Charles; Huang, Shengsong; Tang, Jingjie; Chen, Guoyuan; Li, Jianneng; Zhu, Ziqi; Zhu, Xuyou; Zhou, Shuirong; Gao, Yuanyuan; Hou, Zemin; Fang, Zijun; Xu, Chengdang; Wang, Jianyang; Wu, Denglong; Sharifi, Nima; Li, Zhenfei., Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression., Clinical cancer research : an official journal of the American Association for Cancer Research Vol.25, 2019
Xiao, Haowen; Ding, Yingying; Gao, Yang; Wang, Li-Mengmeng; Wang, Huafang; Ding, Lijuan; Li, Xiaoqing; Yu, Xiaohong; Huang, He., Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage., Cancer cell international Vol.19, 2019
Hu XT, Xing W, Zhao RS, Tan Y, Wu XF, Ao LQ, Li Z, Yao MW, Yuan M, Guo W, Li SZ, Yu J, Ao X, Xu X., HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer, J Exp Clin Cancer Res. 2020 Dec 2;39(1):270. doi: 10.1186/s13046-020-01783-9.
Xu, Juan; Yu, Nanhui; Zhao, Pan; Wang, Fangfang; Huang, Jingcao; Cui, Yushan; Ding, Hong; Yang, Yan; Gao, Yuhan; Pan, Ling; Chang, Hong; Wu, Yu; Xiang, Bing; Gong, Yuping; Shuai, Xiao; Hou, Li; Xie, Liping; Niu, Ting; Liu, Ting; Zhang, Li; Liu, Weiping; Zhang, Wenyan; Qu, Ying; Lin, Wei; Zhu, Yimin; Zhao, Sha; Zheng, Yuhuan, Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma, Frontiers in Oncology. 2021.
Zhong, Wenbin; Cao, Xiuye; Pan, Guoping; Niu, Qun; Feng, Xiaoqin; Xu, Mengyang; Li, Mingchuan; Huang, Yu; Yi, Qing; Yan, Daoguang, ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1, Blood. 2021.
Miao JX, Wang JY, Li HZ, Guo HR, Dunmall LSC, Zhang ZX, Cheng ZG, Gao DL, Dong JZ, Wang ZD, Wang YH., Promising xenograft animal model recapitulating the features of human pancreatic cancer, World J Gastroenterol. 2020 Aug 28;26(32):4802-4816. doi: 10.3748/wjg.v26.i32.4802.
Jiang, Duanfeng; Mo, Qiuyu; Sun, Xiaoying; Wang, Xiaotao; Dong, Min; Zhang, Guozhen; Chen, Fangping; Zhao, Qiangqiang, Pyruvate dehydrogenase kinase 4?mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B?cell lymphoma by affecting the expression of MS4A1/CD20, Cancer Science. 2021.
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